Ensuring the stability of recombinant adeno-associated virus (rAAV) vectors remains a central challenge in gene therapy development. rAAV particles are structurally complex, highly heterogeneous, and sensitive to environmental stress, making it difficult to link analytical changes to functional consequences during manufacturing and storage. A recent Journal of Pharmaceutical Sciencesstudy by Prof. Susumu Uchiyama and colleaguesat…
Understanding how bacterial proteasomes recognize and process their substrates remains a major challenge in infectious disease biology and drug discovery. In Mycobacterium tuberculosis, this challenge is particularly critical, as the proteasome is essential for bacterial survival inside host macrophages and represents an attractive antibacterial target. A recent Nature Communications study by Prof. Siavash Vahidi and…
Adeno-associated virus (AAV) vectors are widely used in gene therapy because of their ability to enable long-term transgene expression with favorable safety profiles. However, immune responses to the AAV capsid remain a major barrier, limiting treatment durability and the feasibility of repeat dosing. A recent Nature Communications study led by Dr. Ronit Mazor and colleagues…
Chromatography and mass spectrometry sample preparation is one of the most critical (and underrated) steps in analytical chemistry—ensuring samples are clean and concentrated enough for accurate, reproducible analysis. Shortchanging sample preparation can compromise data accuracy, reduce method robustness, and even cause timely downtime of expensive instrumentation when it matters most. What Are the Challenges in…
Analytical labs today face mounting pressure: ever more complex samples, rising regulatory demands, and the need to generate answers faster than ever. Traditional mass spectrometry approaches can require compromises, either in data quality or in analytical efficiency, making it harder for scientists to meet demanding timelines with full confidence in their results. Waters XevoTM MRT…
How Sygnature Discovery Supports the 3Rs with LC-MS/MS Scientific Precision and Ethical Innovation In the world of drug discovery, researchers face a critical challenge: how do you generate high-quality, reproducible bioanalytical data while minimizing the ethical and logistical burden of using animals in testing? This is especially so with central nervous system (CNS) drug discovery,…
Whether you are analyzing adeno-associated viruses (AAVs) or virus-like particles, nucleic acids such as RNAs or lipid nanoparticles (LNPs), proteins, or protein complexes, simple and fit-for-purpose tools with speed, accuracy, and precision are essential for driving biotherapeutic innovations forward. In recent years, scientists have increasingly turned to charge detection mass spectrometry (CDMS).
At Waters, we’re constantly innovating our mass spectrometry systems to improve human health, like this groundbreaking advance in breast cancer detection.
Learn more about how absolute power can be more sustainable with the new Xevo TQ Absolute tandem quadrupole mass spectrometer.
Mass spectrometry is gaining popularity in the polymer analysis world. MS has evolved into a highly useful tool for materials science, enabling polymer chemists to investigate macromolecules, chain-by-chain.
Advanced materials companies are using direct mass spectrometry analysis to provide deeper insights into research, development and manufacturing processes.
The new waters_connect for quantitation software, including the new MS Quan app – is designed to allow labs to increase productivity and harness the full potential of their lab.