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From Hidden Assemblies to Drug Target Insight with CDMS and Cryo-EM
A recent JACS study by Prof. Siavash Vahidi and collaborators at the University of Guelph (Canada) highlights how Charge Detection Mass Spectrometry (CDMS) can uncover hidden protein assemblies that conventional methods often miss. By guiding cryogenic electron microscopy (cryo-EM) toward structurally distinct populations, CDMS enabled a deeper understanding of the active architecture and substrate recognition…
Recent Posts
A Toxic Pollutant, a Surprising Polymer, and the CDMS Data That Connected the Dots
Water microdroplets can convert carbon disulfide (CS₂), a toxic industrial pollutant, into a solid polymer at room temperature and without a catalyst. It is a striking example of green chemistry: transforming harmful waste into useful materials under exceptionally mild conditions. But a compelling hypothesis still needs proof. Did a polymer really form, and how did...
The Next Frontier in Nitrosamines Testing: Detection and Risk Assessment in Packaging and IV Infusion Bags
Nitrosamine analysis continues to push analytical labs to new levels of sensitivity, while the evolving regulatory landscape is expanding the conversation beyond traditional testing. As attention turns to other N-nitroso species (i.e., o-NNOs) and potential extractables and leachables (E&L) from packaging materials, such as IV bags, labs face new challenges in detection, quantification, and method...
A New Era for Regulated Labs: AI/ML Innovation as a Real Laboratory Capability
Life sciences organizations are building the next generation of laboratory excellence and are poised for it to be more than just an idea. Over the years, we’ve heard aspirational concepts ranging from a paperless laboratory to Pharma 4.0. We’ve debated concepts and what might be possible someday. The pace of artificial intelligence (AI) advancement has...
From Hidden Assemblies to Drug Target Insight with CDMS and Cryo-EM
A recent JACS study by Prof. Siavash Vahidi and collaborators at the University of Guelph (Canada) highlights how Charge Detection Mass Spectrometry (CDMS) can uncover hidden protein assemblies that conventional methods often miss. By guiding cryogenic electron microscopy (cryo-EM) toward structurally distinct populations, CDMS enabled a deeper understanding of the active architecture and substrate recognition...
From Transcript to LNP Formulation: Measuring Intact mRNA with CDMS
mRNA therapeutics are advancing rapidly, but a major analytical challenge remains: how do you verify that a large, full-length transcript remains intact throughout manufacturing and formulation? A recent Analytical Chemistry article by scientists from Pfizer and Megadalton Solutions demonstrates how charge detection mass spectrometry (CDMS) helped to close this gap. The researchers directly measured intact...
From Complex Workflows to Conversation: How Waters is Bringing Governed, Practical AI Into Laboratory Software
Artificial intelligence (AI) is changing how people interact with software. However, in the lab, innovation must do more than make technology easier to use, it must also support scientific confidence, protect access to data, and fit within established governance. Waters AI Link is designed for that reality, providing a conversational connection to waters_connect Software that...
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