Ensuring the stability of recombinant adeno-associated virus (rAAV) vectors remains a central challenge in gene therapy development. rAAV particles are structurally complex, highly heterogeneous, and sensitive to environmental stress, making it difficult to link analytical changes to functional consequences during manufacturing and storage. A recent Journal of Pharmaceutical Sciencesstudy by Prof. Susumu Uchiyama and colleaguesat…
Adeno-associated virus (AAV) vectors are widely used in gene therapy because of their ability to enable long-term transgene expression with favorable safety profiles. However, immune responses to the AAV capsid remain a major barrier, limiting treatment durability and the feasibility of repeat dosing. A recent Nature Communications study led by Dr. Ronit Mazor and colleagues…
How Sygnature Discovery Supports the 3Rs with LC-MS/MS Scientific Precision and Ethical Innovation In the world of drug discovery, researchers face a critical challenge: how do you generate high-quality, reproducible bioanalytical data while minimizing the ethical and logistical burden of using animals in testing? This is especially so with central nervous system (CNS) drug discovery,…
The collaboration between Waters and AWS has enhanced the waters_connect System Monitoring tool, revolutionizing laboratory productivity. This cloud-based platform provides secure, compliant access to chromatography lab information, allowing users to coordinate work, address system errors, and make informed decisions from anywhere, anytime.
For contract organizations working in the pharmaceutical industry, operating at peak performance and capacity is a vital step towards delivering life-saving therapies.
Recent developments in techniques for rapid and efficient oligonucleotide synthesis and molecular biology technology have expanded the market for manufacturers and service providers in the field. Liquid chromatography coupled with mass spectrometry (LC-MS) workflows play a critically important role.
At Chiesi Group’s Chippenham laboratory in the UK, Waters’ UPLC systems with mass detection and informatics keep the team at the forefront of inhalation drug delivery products.
In Japan, Professor Masanori Kataoka finds that the ACQUITY QDa Mass Detector is suitable for the synthesis and analysis of oligonucleotides – and sees ways to expand its use.
We discuss analytical options using LC and GC with MS/MS to detect the pesticide fipronil in eggs for food safety testing.
Waters Corporation and PRIMORIS Belgium… a reliable relationship It makes sense, doesn’t it? No one likes being let down; disappointed. Especially when the consequences are significant. Take, for example, a specialized food testing laboratory – PRIMORIS Belgium – which is responsible for processing more than 60,000 samples (and analyzing more than 20,000,000 results!) annually. They…
How WEQAS is expanding their capabilities with a Waters Xevo TQ-XS Many laboratories participate in external quality assurance proficiency programs, which enable them to compare their results to those of other laboratories. This is essential for standardization and harmonization of results. Certified reference standards play a key role in the success of EQA schemes. It…
“One of the important reasons that we use Waters LC-MS instruments is that beyond the quality of the products, Waters delivers a high degree of technical training. This provides us with the knowledge and confidence that we can solve our complex research questions.” comments Triskelion’s Richard Bas.