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A recent bioRxiv paper by Dr. Jakub Ujma and colleagues at Waters Corporation, in collaboration with Prof. Martin Jarrold from Indiana University and Megadalton Solutions, describes a major advance—the first commercial benchtop charge detection mass spectrometer (CDMS) based on electrostatic linear ion trap (ELIT) technology. Why does this matter CDMS is uniquely suited for analyzing…
Norovirus virus-like particles (VLPs) are structurally heterogeneous, built from a single capsid protein that self-assembles into multiple geometries, making full characterization by conventional mass spectrometry (MS) extremely difficult. A recent bioRxiv paper by Dr. Charlotte Uetrecht and colleagues at the Centre for Structural Systems Biology (CSSB) in Hamburg, Germany, in collaboration with Waters scientists, demonstrates…
Oligonucleotide therapeutics continue to grow in complexity, and so do the purification challenges that come with them. Scientists need reliable, scalable solutions for preparative oligonucleotide purification. MaxPeak Premier Oligo OBD Columns provide a powerful solution for these workflows, now expanded to include 19mm ID formats. These columns reduce non-specific adsorption, improve recovery, and enable consistent…
For many laboratories, the conversation around cloud and SaaS software has shifted from if to when. The benefits are well understood—reduced infrastructure, greater flexibility, and continuous updates—but the decision itself is rarely simple. Moving to the cloud is not just a technical change. It reshapes how your lab operates, scales, and collaborates. The key is…
Solid‑core (or superficially porous) particles are the foundation of solid core HPLC columns and have earned a reputation for delivering higher efficiency separations than similarly sized, fully porous particles. Chromatographers see this play out repeatedly across small- and large-molecule applications under a wide range of operating conditions. But why solid‑core particles are more efficient is…
As modern biopharma pipelines evolve toward increasingly complex modalities, such as therapeutic oligonucleotides, analytical scientists face a familiar pressure: obtain higher sensitivity from smaller samples, while reducing solvent consumption and workflow burden. Microflow liquid chromatography (LC) has emerged as a powerful strategy to meet these demands, and recent column technology innovations are pushing performance even…
Biologics developers today face unprecedented pressure: tighter timelines, increasingly complex antibody formats, and a growing need for real-time process understanding. Yet many analytical workflows still rely on methods that can’t deliver the speed, sensitivity, or depth required for modern bioprocessing. That’s where advances in Protein A (ProA) affinity chromatography are making a meaningful difference, reshaping…
For more than three decades, Waters Empower Chromatography Data System (CDS) has been the trusted foundation for chromatography data management. Empower Software enables laboratories to address regulatory requirements, deliver consistent results, and scale operations. But the pace of change in today’s scientific world is unprecedented- unlike anything labs have experienced before. Global supply chains, the…
The Role of Enzymes in LC-MS Analysis of Modern Biotherapeutics Enzymes are nature’s catalysts, enabling precise and efficient biochemical transformations. In analytical workflows, enzymatic digestion is a cornerstone technique for breaking down complex biomolecules into smaller, more manageable fragments. This process is critical for applications such as peptide mapping in protein characterization and oligonucleotide mapping…
Slalom chromatography is no longer just a scientific curiosity, it’s a comeback story. Once sidelined due to limited reproducibility and unclear mechanisms, this technique is now gaining momentum thanks to the rise of nucleic acid therapeutics and advances in UHPLC systems. But its revival wasn’t accidental. It took a year-long deep dive into DNA physics,…
Laboratory information management systems (LIMS) are often hailed as the cornerstone of modern lab operations, central to digital transformation and essential for regulatory compliance. They’re positioned as the “digital backbone” of the lab, helping manage samples, data, and routine workflows. And in many ways, that reputation is well-earned. But here’s the reality: A LIMS alone…
Chromatography and mass spectrometry sample preparation is one of the most critical (and underrated) steps in analytical chemistry—ensuring samples are clean and concentrated enough for accurate, reproducible analysis. Shortchanging sample preparation can compromise data accuracy, reduce method robustness, and even cause timely downtime of expensive instrumentation when it matters most. While the fundamental goals of…