-
Toward Redosable Gene Therapy: Engineering AAVs to Evade T‑Cells
Adeno-associated virus (AAV) vectors are widely used in gene therapy because of their ability to enable long-term transgene expression with favorable safety profiles. However, immune responses to the AAV capsid remain a major barrier, limiting treatment durability and the feasibility of repeat dosing. A recent Nature Communications study led by Dr. Ronit Mazor and colleagues
Recent Posts
What’s Really Happening to Your rAAV Under Stress?
Ensuring the stability of recombinant adeno-associated virus (rAAV) vectors remains a central challenge in gene therapy development. rAAV particles are structurally complex, highly heterogeneous, and sensitive to environmental stress, making it difficult to link analytical changes to functional consequences during manufacturing and storage. A recent Journal of Pharmaceutical Sciencesstudy by Prof. Susumu Uchiyama and colleaguesat...
Seeing What Others Missed: How CDMS Unlocked Proteasome Function
Understanding how bacterial proteasomes recognize and process their substrates remains a major challenge in infectious disease biology and drug discovery. In Mycobacterium tuberculosis, this challenge is particularly critical, as the proteasome is essential for bacterial survival inside host macrophages and represents an attractive antibacterial target. A recent Nature Communications study by Prof. Siavash Vahidi and...
Toward Redosable Gene Therapy: Engineering AAVs to Evade T‑Cells
Adeno-associated virus (AAV) vectors are widely used in gene therapy because of their ability to enable long-term transgene expression with favorable safety profiles. However, immune responses to the AAV capsid remain a major barrier, limiting treatment durability and the feasibility of repeat dosing. A recent Nature Communications study led by Dr. Ronit Mazor and colleagues...
Considering Adopting the Cloud in Your Lab? What to Consider When Choosing Cloud Software
For many laboratories, the conversation around cloud and SaaS software has shifted from if to when. The benefits are well understood—reduced infrastructure, greater flexibility, and continuous updates—but the decision itself is rarely simple. Moving to the cloud is not just a technical change. It reshapes how your lab operates, scales, and collaborates. The key is...
Identifying Critical Quality Attributes in Drug Products: Your Key to Ensuring Safe and Effective Therapeutics
In drug manufacturing, there is no room for error. Every decision, from early formulation to final release, must ensure a product is safe, effective, and consistent. At the center of this process are critical quality attributes (CQAs), the measurable properties that define whether a drug meets its required standards. In this blog, we break down...
Catching Insulin Aggregation Before It Goes Rogue: DLS Instrument in Action
In hospital intensive care units, insulin is a critical therapeutic used to maintain tight glycemic control. While it is typically supplied at 100 units/mL, clinical protocols dilute it to 1 unit/mL for continuous infusion, commonly known as the insulin infusion protocol (IIP). At these low concentrations, ensuring stability becomes challenging, especially when aggregation or surface...
Popular Topics
ACQUITY QDa (17) bioanalysis (12) biologics (17) biopharma (50) biopharmaceutical (59) biotherapeutics (24) case study (20) chromatography (14) data integrity (23) food analysis (12) HPLC (15) informatics (12) LC-MS (27) liquid chromatography (LC) (25) mass detection (16) mass spectrometry (MS) (61) method development (13) particle analysis (21)