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PROTACs Are Different: What Does That Mean for Liquid Chromatography?
As drug discovery moves beyond traditional small-molecule inhibitors, analytical scientists are being asked to characterize increasingly complex molecules. Proteolysis-targeting chimeras (PROTACs) are one example. PROTACs combine two binding elements with a linker to selectively target proteins for degradation. Their larger size, flexibility, and multiple functional groups can create new analytical considerations compared to more conventional…
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Xevo MRT System in Action: Driving Innovation in Mass Spectrometry
Analytical labs today face mounting pressure: ever more complex samples, rising regulatory demands, and the need to generate answers faster than ever. Traditional mass spectrometry approaches can require compromises, either in data quality or in analytical efficiency, making it harder for scientists to meet demanding timelines with full confidence in their results. Waters XevoTM MRT...
Staying Current: Why Upgrading Matters for Your Lab’s Future
In the fast-paced world of life sciences, staying current isn’t just a best practice, it is a necessity. As technology evolves, so do the risks of your lab falling behind and risking non-compliance with CGMP standards. With general releases of WindowsTM 10 Operating System reaching end of support on October 14, 2025,1 now is the...
How Advances in Bioanalysis Drive Scientific and Ethical Progress
How Sygnature Discovery Supports the 3Rs with LC-MS/MS Scientific Precision and Ethical Innovation In the world of drug discovery, researchers face a critical challenge: how do you generate high-quality, reproducible bioanalytical data while minimizing the ethical and logistical burden of using animals in testing? This is especially so with central nervous system (CNS) drug discovery,...
Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with...
Protecting Your Laboratory Data: Cybersecurity at Waters
With the ever-present threat of cyberattacks, safeguarding laboratory data has become a top priority for scientists across the globe. Many labs are accelerating digitalization efforts, but that could expose their data to greater risks. The Increase in Lab Digitalization: Effects on Cybersecurity As it turns out, the increase in digitalization, particularly the shift to the...
Preventing The Next Pandemic: Leveraging the Andrew+ Pipetting Robot and Extraction+ Connected Device to Monitor Antimicrobials in Hospital Wastewater
Dr. Takashi Azuma’s research on hospital wastewater monitoring at Osaka Medical and Pharmaceutical University may prevent the next global pandemic. Five years later, it is difficult to forget the horror of the Covid-19 pandemic. Leaving behind a death toll estimated at between 18.2 million to 33.5 million, the greatest recession since the Great Depression, and...
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