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PROTACs Are Different: What Does That Mean for Liquid Chromatography?
As drug discovery moves beyond traditional small-molecule inhibitors, analytical scientists are being asked to characterize increasingly complex molecules. Proteolysis-targeting chimeras (PROTACs) are one example. PROTACs combine two binding elements with a linker to selectively target proteins for degradation. Their larger size, flexibility, and multiple functional groups can create new analytical considerations compared to more conventional…
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Optimizations in High-Throughput Process Development: Enhancing Efficiency and Precision
High-throughput process development (HTPD) refers to the systematic approach of performing numerous experiments simultaneously to expedite the optimization and development of biopharmaceutical processes. This innovative methodology significantly transforms and accelerates how scientists, clinicians, and engineers tackle the challenges associated with bioprocess development. By employing HTPD, organizations can accelerate process optimization, reduce operational costs, and improve...
Advances in Exosome Quantification Techniques
The study of exosomes has gained substantial attention in recent years due to their significant potential in diagnostics, therapeutic applications, and as biomarkers for various diseases. Exosomes, which are extracellular vesicles (EVs) ranging from 30 to 150 nm when stable and in solution, are secreted by various cells and carry molecular signals like proteins, lipids, and RNAs to recipient cells....
OligoWorks SPE Kits: Boosting Oligonucleotide Bioanalysis Efficiency
New OligoWorks Solid Phase Extraction (SPE) Kits for extraction and bioanalysis of oligonucleotides deliver advantages over liquid-liquid extraction (LLE) and other existing SPE kits and sample preparation methods. Read on to discover how.
Gene and Cell Therapy Commercialization Advances, Challenges, and the Path to Success
Cell and gene therapy appear poised to revolutionize drug and vaccine discovery, with the potential to address diseases that have been untouchable, and treat others with more successful therapies. But the road to success has been rocky, and many obstacles remain for both gene and cell therapy commercialization. A Look Back: The History of Gene Therapy Therapeutic Targets Gene...
Increasing Lab Efficiency with Amazon Web Services to Enable Real-Time Remote Access to Lab Information
The collaboration between Waters and AWS has enhanced the waters_connect System Monitoring tool, revolutionizing laboratory productivity. This cloud-based platform provides secure, compliant access to chromatography lab information, allowing users to coordinate work, address system errors, and make informed decisions from anywhere, anytime.
Data Integrity and Compliance in a Laboratory Environment – Best Practices
Data integrity requires laboratories to handle data consistently from beginning to end, with measures like encryption, access controls, and regular backups to maintain compliance with regulatory standards such as GDPR, HIPAA, and SOX. The introduction of new technologies within the scientific world further highlights the need for strong regulations and compliance when dealing with the data...
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