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Charge Detection Mass Spectrometry (CDMS): Unprecedented Direct Measurement for the Characterization of Mega-Mass Biomolecules
Whether you are analyzing adeno-associated viruses (AAVs) or virus-like particles, nucleic acids such as RNAs or lipid nanoparticles (LNPs), proteins, or protein complexes, simple and fit-for-purpose tools with speed, accuracy, and precision are essential for driving biotherapeutic innovations forward. In recent years, scientists have increasingly turned to charge detection mass spectrometry (CDMS).
Recent Posts
Sample Prep before LC-MS Quantification of Peptides and Proteins
Confronting the challenge of sensitivity and sample loss As a relative newcomer to peptide and protein quantification coming from the small molecule world, I have learned that I need to think differently, and more creatively, to meet the challenges of these molecules. As scientists with assay sensitivity goals, we sometimes have to take extra steps...
Lost Samples in the Container: Non-specific Binding and the Impact of Blocking Agents
My sample stayed in the solution…or did it? Samples are precious. Well-prepared samples are the starting point of all successful experiments. That’s why we spend time and effort on sample preparation; so that the resulting samples are ready for downstream LC analyses. When we think of good sample prep and handling, we emphasize the sample...
Amgen, UCLA, and University of Arizona Use BioResolve RP mAb Polyphenyl Columns for Rapid LC-MS Screening of Membrane Proteins
As a chromatography scientist at Waters, I often get the opportunity to travel to different laboratories around the world and to meet with various types of researchers. This allows me to stay up to date on the newest scientific trends and topics, particularly in the fast growing world of biopharmaceutical analysis. In June of this...
ACQUITY UPLC – 15 Years On and Still Going Strong
The 30th James L. Waters Annual Symposium will take place on Monday, March 18 in Philadelphia as part of Pittcon 2019. The theme of this year’s Symposium focuses on early research efforts required to develop Ultra High Pressure Liquid Chromatography (UHPLC) and the impact that the adoption of this technology had on the analytical chemistry...
Making Mass Analysis Smarter for Biopharma
There’s no question that we’ve entered the age of smart technology. Your phone, your home, your refrigerator, even your light bulbs are all getting smarter. Such technologies do more and more to run themselves, removing steps and complexity, while making user interactions easier and more intuitive. They continually improve, and as they do they become...
Where Did My Sample Go?
Non-specific binding of protein and peptides continues to plague scientists with low recovery. high variability, and poor sensitivity. Are you doing enough to combat non-specific binding?
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