liquid chromatography (LC)

  • Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques

    By Chris Collins Reading Time: 5 minutes

    Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies.  What Are Polar Compounds?  Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…

  • Sample Vials Through the Ages

    By Markus Wanninger Reading Time: 5 minutes

    From the 1700’s to the modern age, sample vials have been an integral part of the workflow in analytical laboratories. Today, we still test and certify the whole vial kit.

  • The Quest for Maximum LC Performance: A Well-Packed Column Bed

    By Jonathan Turner Reading Time: 6 minutes

    As chromatographers seek maximum separation performance on their liquid chromatography (LC) systems, a key factor is the use of LC columns with an optimally packed column bed density. Solid-core columns manufactured with strict quality control for their packed bed density enable top efficiency, mechanical stability, and performance – no matter how tough your method conditions….

  • Comprehending COVID-19: How Consumables Can Increase LC-MS/MS Sensitivity

    By Hazel Dickson Reading Time: 4 minutes

    During 2020, we collaborated with many of our customers to develop targeted liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) methods to detect SARS-CoV-2 (the virus that causes COVID-19) from biological samples. However, the combination of the biological specimen, the sample collection medium, the viral load threshold, and the need for a high throughput method gave rise to…

  • Nuts About Christmas … And Mycotoxin Detection

    By Simon Hird Reading Time: 7 minutes

    A bowl of nuts, with polished or carved nutcrackers, is part of many traditional winter holiday feasts. Growing up in England in the 1970s, I enjoyed hazelnuts, almonds, walnuts and Brazil nuts as special treats for the Christmas holiday. Once I’d wrestled with a nutcracker, seemingly designed to send nuts and shards of shell across…

  • Tools for Chromatographic Success: Three Ways to Support Data Quality in Routine Analysis

    By Heather Longden Reading Time: 6 minutes

    Avoiding the pitfalls of data quality and integrity in the Pharma QC laboratory while running routine analyses is an ongoing challenge. Regulatory violations are frequently a result of a lack of complete data, suspect data, and improper audit trails. A recent report from Deloitte stated that data integrity violations account for over 70% of the…

  • Chords and Chemistry and the Benefits of Choosing Wisely

    By Robert Buco Reading Time: 3 minutes

    “A true measure of excellence for Waters is in orchestrating consistent instrument and chemistry optimization across applications, methods, and workflows.” I was on a job interview – more specifically, for my first position at Waters – where I was asked a compelling question. The question had to do with the consideration that Waters was a…

  • Bring efficiency back to your lab: How aging technology hinders ideal performance

    By Waters Staff Reading Time: 6 minutes

    In this series, we review considerations for keeping your lab at the forefront of science. As we adjust to living and working in a pandemic and anticipate future global and geopolitical events, Waters remains dedicated to supporting your business and unlocking the potential of your science. Our holistic separations solutions and expert support help you…

  • Choosing the Correct Column for Chromatographic Selectivity

    By Euan Ross Reading Time: 5 minutes

    When developing a method for the routine multiresidue analysis of pesticides in food commodities there are several factors that need to be considered when selecting which liquid chromatography (LC) column to use. The requirements include: Good retention for a range of physiochemical properties (polar, non-polar, base, acid). Moderate to high resolution (peak capacity). Sample extracts…