Chromatography and mass spectrometry sample preparation is one of the most critical (and underrated) steps in analytical chemistry—ensuring samples are clean and concentrated enough for accurate, reproducible analysis. Shortchanging sample preparation can compromise data accuracy, reduce method robustness, and even cause timely downtime of expensive instrumentation when it matters most. What Are the Challenges in…
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
New OligoWorks Solid Phase Extraction (SPE) Kits for extraction and bioanalysis of oligonucleotides deliver advantages over liquid-liquid extraction (LLE) and other existing SPE kits and sample preparation methods. Read on to discover how.
From the 1700’s to the modern age, sample vials have been an integral part of the workflow in analytical laboratories. Today, we still test and certify the whole vial kit.
The Waters MassTrak Immunosuppressant Calibrator, Control, and Internal Standard Sets, soon available, are developed to help laboratories utilize LC-MS/MS with confidence in their assay results.
Combining BioAccord, our most capable MS detection platform, with ACQUITY Premier UPLC, our highest performance LC system, to demonstrate superior performance.
As chromatographers seek maximum separation performance on their liquid chromatography (LC) systems, a key factor is the use of LC columns with an optimally packed column bed density. Solid-core columns manufactured with strict quality control for their packed bed density enable top efficiency, mechanical stability, and performance – no matter how tough your method conditions….
During 2020, we collaborated with many of our customers to develop targeted liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) methods to detect SARS-CoV-2 (the virus that causes COVID-19) from biological samples. However, the combination of the biological specimen, the sample collection medium, the viral load threshold, and the need for a high throughput method gave rise to…
A bowl of nuts, with polished or carved nutcrackers, is part of many traditional winter holiday feasts. Growing up in England in the 1970s, I enjoyed hazelnuts, almonds, walnuts and Brazil nuts as special treats for the Christmas holiday. Once I’d wrestled with a nutcracker, seemingly designed to send nuts and shards of shell across…
Avoiding the pitfalls of data quality and integrity in the Pharma QC laboratory while running routine analyses is an ongoing challenge. Regulatory violations are frequently a result of a lack of complete data, suspect data, and improper audit trails. A recent report from Deloitte stated that data integrity violations account for over 70% of the…
“A true measure of excellence for Waters is in orchestrating consistent instrument and chemistry optimization across applications, methods, and workflows.” I was on a job interview – more specifically, for my first position at Waters – where I was asked a compelling question. The question had to do with the consideration that Waters was a…
In this series, we review considerations for keeping your lab at the forefront of science. As we adjust to living and working in a pandemic and anticipate future global and geopolitical events, Waters remains dedicated to supporting your business and unlocking the potential of your science. Our holistic separations solutions and expert support help you…