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Charge Detection Mass Spectrometry (CDMS): Unprecedented Direct Measurement for the Characterization of Mega-Mass Biomolecules
Whether you are analyzing adeno-associated viruses (AAVs) or virus-like particles, nucleic acids such as RNAs or lipid nanoparticles (LNPs), proteins, or protein complexes, simple and fit-for-purpose tools with speed, accuracy, and precision are essential for driving biotherapeutic innovations forward. In recent years, scientists have increasingly turned to charge detection mass spectrometry (CDMS).
Recent Posts
In Need of Some Reversed Phase Polar Acid Relief
Retaining polar analytes using reversed phase (RP) chromatographic conditions have long frustrated scientists. Trying to promote interactions between polar analytes and a non-polar reversed phase surfaces can often bring the most experienced separation scientist to their breaking point. Polar acids specifically present their own set of challenges that make them particularly difficult to retain under...
Uncovering the Why of Breast Cancer with LC/MS solutions
Chances are that you or someone you know has been directly impacted by breast cancer. With 2,088,849 new cases and 626,679 deaths globally,1 it is the most frequently diagnosed cancer in women in most countries (154 of 185) and is the leading cause of cancer death in women in over 100 countries. Fortunately, significant strides...
A Relentless Approach to Delivering Benefit to Customers in Everything We Do
At Waters there is a fundamental ethic in the company around doing the right thing to help customers, fellow employees and the world by advancing science to enhance human health and well-being. Everything we do traces to this purpose and is based on a singular imperative to “deliver benefit”, given to us by our founder...
Bring efficiency back to your lab: How aging technology hinders ideal performance
In this series, we review considerations for keeping your lab at the forefront of science. As we adjust to living and working in a pandemic and anticipate future global and geopolitical events, Waters remains dedicated to supporting your business and unlocking the potential of your science. Our holistic separations solutions and expert support help you...
Addressing the Mystery of Sample Loss
Many years ago, I was hired by a biopharma company to develop analytical methods for therapeutic oligonucleotides. When a new colleague warned me about sample loss on LC columns I looked at him with skepticism. “Yes,” he insisted, “part of your DNA sample may be irreversibly bound to the column and you will never see...
Mutagenic Impurity Risk Assessment Throughout the Development and Manufacturing Process
Since the early 2000s and the advent of the first guidance relating to mutagenic impurities developed by the European Medicines Agency (EMA), it has been necessary to assess the risk posed by mutagenic impurities. Although initially it was thought that avoidance was an option, it quickly became apparent that this was not a viable strategy. ...
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