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On Wednesday evening after dinner and my usual digestif, I was watching the webcast “Making Ion Mobility Mass Spectrometry Routine” when my son walked by. “Wow dad, that’s kind of cool! What the heck is it?” he asked. “It’s ion mobility!! It’s an orthogonal and complementary resource for chromatography and mass spectrometry…” The digestif was…
Webinar Highlights | Understanding the Impact of System Dispersion on Separation Performance Hi, I am Jonathan E. Turner, Product Marketing Manager for ACQUITY® UPLC® and CORTECS® lines of columns at Waters Corporation. I recently conducted a webinar that talked about the changes we have seen the last 10 years and the substantial improvements in both…
Webinar Highlights | Simplifying Methods Transfer: Novel Tools for Replicating Your Established Methods on an ACQUITY Arc System I’m Dr. Paula Hong, Principal Scientist at Waters Corporation. I recently conducted a webinar that talked about the instrument characteristics that can impact transfer of established reversed-phase methods across both HPLC and UHPLC systems. These factors include dwell…
You might not like the answer… So the other day, I was with a customer when they asked me, “Viet, there are so many detectors out there! How do I know which one I need?” To which I answered with the one comment that all of you will love to hate, “It depends!” Detectors for…
Multiple attribute monitoring has become a hot topic of discussion within biopharmaceutical organizations as the methodology allows detection and measurement of more critical quality attributes than conventional methods. Waters recently sponsored an outstanding webinar on this topic, hosted by Genetic Engineering News and presented by our own Biopharmaceutical Senior Manager, Sean M. McCarthy, Ph.D. Watch…
NASA made history again recently as the spacecraft New Horizons successfully flew by Pluto, the last of the nine ‘classical’ planets, to gather valuable data about an area of our solar system that we know very little about. The spacecraft managed to successfully gather the most detailed images of Pluto ever seen whilst hurtling past…
For many years, the prevailing wisdom has been that in the event of chromatographic coelution, caused by complex samples, what is needed is a high-resolution mass spectrometer that can accurately identify different species contained within that single peak. However, even with the highest levels of resolution some ionisation patterns can be obscured by other species…
Melamine and cyanuric acid (CA) are low mass, nitrogen-rich compounds that have been linked to protein adulteration in various foodstuffs in the past.1 While melamine and cyanuric acid are not individually toxic, in combination they can sometimes form an adduct compound through hydrogen bonding, melamine cyanurate, that produce sharp crystals which can cause internal organ failure…
For more than five decades, attempts have been made to improve liquid chromatography separations performance by reducing the particle size of the stationary phase. However, the benefits of doing so can only be realized if the LC instrument provides an appropriate amount of extra-column dispersion (band spreading) in relation to the volume of the column…
Sitting in the Waters’ John Dalton Suite in Wilmslow, England two weeks ago felt somewhat duplicitous. Here we were, in the part of the world considered the birthplace of Mass Spectrometry (MS), about to embark on a two-day workshop with 20 key collaborators and thought leaders to discuss Ion Mobility Spectroscopy (IMS), its use in contemporary structural…
Characterization of packaging in various industries has become more important due to ever-increasing global regulations. The first regulations for plastics used in food packaging and contact materials were established in 1982 in Europe1, which have been expanded in recent years.2 In the pharmaceutical field the need for extractables testing was recognized in the 1990s.3 Manufacturers…
The spatial distribution of molecules throughout a sample can provide a wealth of information regarding biological, physiological, and chemical phenomena and processes. One of the most recent and exciting developments in the study of molecular distributions has been the use of mass spectrometry (MS) to specifically measure molecular targets in order to determine their distribution…