Our expertise drives innovation, development, and application of informatics and software that continue to enable leading pharmaceutical, environmental, food & beverage and chemical materials organizations to accelerate decision-making, improve laboratory effectiveness, and get products to market faster.
Solid‑core (or superficially porous) particles are the foundation of solid core HPLC columns and have earned a reputation for delivering higher efficiency separations than similarly sized, fully porous particles. Chromatographers see this play out repeatedly across small- and large-molecule applications under a wide range of operating conditions. But why solid‑core particles are more efficient is…
As modern biopharma pipelines evolve toward increasingly complex modalities, such as therapeutic oligonucleotides, analytical scientists face a familiar pressure: obtain higher sensitivity from smaller samples, while reducing solvent consumption and workflow burden. Microflow liquid chromatography (LC) has emerged as a powerful strategy to meet these demands, and recent column technology innovations are pushing performance even…
Biologics developers today face unprecedented pressure: tighter timelines, increasingly complex antibody formats, and a growing need for real-time process understanding. Yet many analytical workflows still rely on methods that can’t deliver the speed, sensitivity, or depth required for modern bioprocessing. That’s where advances in Protein A (ProA) affinity chromatography are making a meaningful difference, reshaping…
For more than three decades, Waters Empower Chromatography Data System (CDS) has been the trusted foundation for chromatography data management. Empower Software enables laboratories to address regulatory requirements, deliver consistent results, and scale operations. But the pace of change in today’s scientific world is unprecedented- unlike anything labs have experienced before. Global supply chains, the…
The Role of Enzymes in LC-MS Analysis of Modern Biotherapeutics Enzymes are nature’s catalysts, enabling precise and efficient biochemical transformations. In analytical workflows, enzymatic digestion is a cornerstone technique for breaking down complex biomolecules into smaller, more manageable fragments. This process is critical for applications such as peptide mapping in protein characterization and oligonucleotide mapping…
Slalom chromatography is no longer just a scientific curiosity, it’s a comeback story. Once sidelined due to limited reproducibility and unclear mechanisms, this technique is now gaining momentum thanks to the rise of nucleic acid therapeutics and advances in UHPLC systems. But its revival wasn’t accidental. It took a year-long deep dive into DNA physics,…
Laboratory information management systems (LIMS) are often hailed as the cornerstone of modern lab operations, central to digital transformation and essential for regulatory compliance. They’re positioned as the “digital backbone” of the lab, helping manage samples, data, and routine workflows. And in many ways, that reputation is well-earned. But here’s the reality: A LIMS alone…
Chromatography and mass spectrometry sample preparation is one of the most critical (and underrated) steps in analytical chemistry—ensuring samples are clean and concentrated enough for accurate, reproducible analysis. Shortchanging sample preparation can compromise data accuracy, reduce method robustness, and even cause timely downtime of expensive instrumentation when it matters most. What Are the Challenges in…
We are pleased to announce that Waters Corporation has successfully achieved SOC 2® Type II attestation for the waters_connect Cloud software platform, in accordance with the American Institute of Certified Public Accountants (AICPA) standards. This accomplishment reflects our unwavering commitment to safeguarding customer data, building trust, and upholding the highest standards of security, availability, and…
Analytical labs today face mounting pressure: ever more complex samples, rising regulatory demands, and the need to generate answers faster than ever. Traditional mass spectrometry approaches can require compromises, either in data quality or in analytical efficiency, making it harder for scientists to meet demanding timelines with full confidence in their results. Waters XevoTM MRT…
In the fast-paced world of life sciences, staying current isn’t just a best practice, it is a necessity. As technology evolves, so do the risks of your lab falling behind and risking non-compliance with CGMP standards. With general releases of WindowsTM 10 Operating System reaching end of support on October 14, 2025,1 now is the…
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…