Coming to Grips with the Reality of Automation in Analytical Laboratories
Could you utilize your automation setup more efficiently if you had a solution for simpler, easier sample prep? The survey says YES!
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Maximizing LC Column Lifetime: 3 Tips to Reduce Physical Deterioration
Three tips to help you reduce physical contaminants from impacting your chromatographic column’s longevity.
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Infographic: What’s the Best Column for Polar Compound Retention?
Retaining and separating highly polar, water-soluble organic compounds has been a challenge for separations scientists who prefer reversed-phase chromatography as their technique of choice. See how Waters has addressed these analytical challenges with our T3 columns.
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Oligo-mania! Interest in Oligonucleotides Continues to Rise
From oligonucleotides and peptides to messenger RNA and CRISPR, ’tides are enjoying their time in the sun A year ago we wrote how oligonucleotide therapeutic development, which had seen a huge wave of investment in the late 1990s and early 2000s followed by a precipitous decline in the late 2000s, was once again on the…
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A Leading CRO’s Customer Focus Leads to Improvements in Quality and Productivity
“One of the important reasons that we use Waters LC-MS instruments is that beyond the quality of the products, Waters delivers a high degree of technical training. This provides us with the knowledge and confidence that we can solve our complex research questions.” comments Triskelion’s Richard Bas.
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A CRO Leads the Way for Biotherapeutics Amid its Own ‘Field of Dreams’
“If You Build it, He Will Come” Urged on by a voice no one else could hear, Ray Kinsella, played by Kevin Costner in the movie Field of Dreams, cleared a few acres of corn to build a baseball field. Shortly after, magical things began to happen. When you first set eyes on the headquarters…
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Analytical Tools for Developing Biosimilars: Part 3, Glycosylation, Aggregation, and Charge Variants
In biotherapeutics, the state of glycosylation has a direct and pronounced effect of the structure, stability, serum half-life, immunogeneicity and bioactivity of the molecule, and constitutes a critical quality attribute (CQA). In our study, characterizing and comparing the glycosylation profile of infliximab began by examining the glycosylation profiles from intact and reduced subunit mass data.
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Analytical Tools for Developing Biosimilars: Part 2, Peptide Analysis
Advancements in High-Resolution Analytics for Characterization of Innovator and Biosimilar Therapeutics Part 2: Peptide Analysis of Infliximab
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How Analytical Technologies Support the Development of Biosimilar Drugs
Advancements in High-Resolution Analytics for the Characterization of Innovator and Biosimilar Therapeutics As the pharmaceutical industry continues to evolve its focus from small-molecule drugs to balanced product portfolios that include protein therapeutics, analytical chemists are increasingly challenged to produce routine and automated characterization workflows that move innovator and biosimilar biopharmaceutical products forward through development and…
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Infographic: Large Molecules Have a 2X Greater FDA Approval Rate Than Small Molecule Drugs
It’s no surprise that pharma is ‘Thinking Large’ Large molecules are dominating pharma sales and FDA approvals. At the end of 2015, seven of the top 10 best-selling prescription drugs were large molecules. According to a 2014 article in Nature, the overall approval rate for small and large molecule therapeutics is nearly 10% (comprised of lead and secondary…
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Waters and BioanalysisZone are Highlighting our Bioanalytical Chemists
Like the black panther, are analytical scientists going extinct? In a presidential election year, we are reminded of the many tough choices we face—Democrats or Republicans, plastic or paper, ketchup or mustard, soccer or football. And as we watched the Olympic track and field events, for instance, we saw the margin between first and last…
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Is using Microflow LC in an Industrial Setting Really that Cumbersome?
Microflow or nanoflow chromatography has been used mostly in the academic and fundamental research environment in the past for its various advantages over analytical liquid chromatography, but rarely in the industrial settings. This is most likely because many of us believe it is a pain-in-the-neck technique to perform! But is this a reality or just…
