We bring high-value technologies designed to solve critical, analytical problems. We enable profound discoveries, optimize lab operations and ensure regulatory compliance. We help customers turn global industry challenges into the medicines that offer hope.
As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source…
The quality issues of biopharmaceutical therapeutics are definitely different from chemical drugs because of the increased complexity of manufacturing processes and complexity of the biologic molecules themselves. There is an increasing need for detailed product characterization and control of the manufacturing process. Sheng Hou et.al. have developed and validated a practical, cost efficient, robust adalimumab…
Ken Fountain, Director of Biopharmaceutical Business Development at Waters, recently returned from an insightful trip to Asia where he visited Waters customers in South Korea and attended the China Biopharma Executive Summit in Shanghai, in which Waters was a sponsor. We caught up with him and asked him to share his thoughts about the biopharmaceutical…
You are the hunter in a landscape of scientific gatherers, the stealthy SEAL of DMPK, the nimble ninja of ADME. You are a Metabolite ID scientist. Traditionally, Met ID labs have been a fixture of any pharmaceutical company worth its salt. Now, imagine that your proud band of comrades has been phased out, split…
As infectious diseases go, tuberculosis (TB) is clearly one of the worst. Easily spread through the air by those with an active infection, it is a scourge that is decimating developing countries. The World Health Organization (WHO) estimates that, in 2014, 9.6 million people fell ill with the disease and 1.5 million died, with 95%…
As regulators focus in on the critical quality attributes of biotherapeutics, what can biopharmaceutical labs in late development or QC do to increase confidence in their bioseparations – other than to run more assays?
ProteinWorks and GlycoWorks kits address more than sample prep challenges One of the most challenging parts of an LC-MS workflow happens before analytical chemists even turn to their instrument: Sample preparation. Get it right, and the analytical run performs as expected. Get it wrong, and the assay has any number of problems, from poor sensitivity…
I recently presented a webinar describing some techniques and tools used for effectively using the QDa Mass Detector with liquid chromatography systems. Several attendees submitted questions that may be of general interest to a broader audience. It is better, as you said, to use negative mode for acidic compounds (like carboxylic acid), but these…
What can you get all the top Pharma and CRO’s scientists to agree on? That the biopharma industry is growing and quantifying biotherapeutics for bioanalysis is difficult – but you have options.
The development of chromatographic methods for natural products is challenging due to the complexity of the sample matrix and analyte chemistry. However, by understanding the fundamental parameters of your chromatography and strategies for efficient detection, there are many ways to overcome these difficulties. I recently presented a webinar describing some techniques and tools used for…
On Wednesday evening after dinner and my usual digestif, I was watching the webcast “Making Ion Mobility Mass Spectrometry Routine” when my son walked by. “Wow dad, that’s kind of cool! What the heck is it?” he asked. “It’s ion mobility!! It’s an orthogonal and complementary resource for chromatography and mass spectrometry…” The digestif was…
Multiple attribute monitoring has become a hot topic of discussion within biopharmaceutical organizations as the methodology allows detection and measurement of more critical quality attributes than conventional methods. Waters recently sponsored an outstanding webinar on this topic, hosted by Genetic Engineering News and presented by our own Biopharmaceutical Senior Manager, Sean M. McCarthy, Ph.D. Watch…