A Day in the Life of Michelle Wood, R&D Toxicology Manager, Scientific Operations
Michelle and her team are responsible for identifying high-demand assays and developing appropriate LC-MS solutions for use in toxicology.
We advance human health and well-being by providing an extensive portfolio of in-vitro diagnostic (IVD) systems, reagent kits, and software used by thousands of hospitals and laboratories worldwide. Most notably, Waters delivers technologies for newborn screening, an area of clinical diagnostics that has made a healthy adult life possible for millions.
Michelle and her team are responsible for identifying high-demand assays and developing appropriate LC-MS solutions for use in toxicology.
Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding of biological systems in terms of drug development and treatment. Understanding the context of analytical results is driving current research,…
The world is facing an unprecedented convergence of environmental and lifestyle factors that dramatically increase our risk of chronic disease. Global warming, antimicrobial resistance, aging populations, and the prevalence of lifestyle-related illnesses are systematically affecting populations around the world and posing some of the greatest scientific and public health threats seen in modern times. These…
The spatial distribution of molecular species in a sample can provide a wealth of information about biological, chemical and physiological processes. Mass spectrometry (MS) imaging is a rapidly developing research technique that enables specific measurement of molecular targets at complex surfaces. This direct-from-sample analytical technique provides researchers with the information needed to quickly and objectively…
In biomedical research, scientists need the ability to accurately and precisely measure a biomarker or set of biomarkers in some disease vs. healthy experimental design. The ability to measure something depends on the ability of the measurement methodology, including analytical tools, to accurately and precisely quantify the true value for the object of interest. Accuracy:…
“Fast is fine; but accuracy is everything.” The quote is attributed to the famous Wyatt Earp, a sharpshooter and lawman who, with help from his two brothers, sent three outlaws to their graves in the Gunfight at the O.K. Corral in Tombstone, Arizona in 1881. One hundred and twenty five years later, Dr. Rob Fitzgerald…
How does mass spectrometry (MS) imaging provide a molecular image that can be used for the biochemical characterization of histological images? A rapidly developing technique for clinical research, MS imaging enables investigation of the spatial distribution of molecules at complex surfaces. It’s a direct-from-sample analytical technique that provides researchers with the information needed to quickly…
According to published reports by Hiscox UK in 2008, just listening to the sound of a sports car increased salivary testosterone levels in male and female participants. Another study, by Gad Saad et al, measured a testosterone increase in men who were given the opportunity to drive a $150,000 Porsche 911 Carrera Cabriolet for an…
U.S. FDA Prepares to Oversee LDTs Recently, the U.S. Food and Drug Administration’s Office of Public Health Strategy and Analysis issued an interesting (and much anticipated) report regarding Laboratory Developed Tests (LDTs). The Agency has consistently cited a need for greater oversight of LDTs out of concern for public safety. Laboratory Developed Tests used to…
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