The development of chromatographic methods for natural products is challenging due to the complexity of the sample matrix and analyte chemistry. However, by understanding the fundamental parameters of your chromatography and strategies for efficient detection, there are many ways to overcome these difficulties. I recently presented a webinar describing some techniques and tools used for…
On Wednesday evening after dinner and my usual digestif, I was watching the webcast “Making Ion Mobility Mass Spectrometry Routine” when my son walked by. “Wow dad, that’s kind of cool! What the heck is it?” he asked. “It’s ion mobility!! It’s an orthogonal and complementary resource for chromatography and mass spectrometry…” The digestif was…
Webinar Highlights | Understanding the Impact of System Dispersion on Separation Performance Hi, I am Jonathan E. Turner, Product Marketing Manager for ACQUITY® UPLC® and CORTECS® lines of columns at Waters Corporation. I recently conducted a webinar that talked about the changes we have seen the last 10 years and the substantial improvements in both…
U.S. FDA Prepares to Oversee LDTs Recently, the U.S. Food and Drug Administration’s Office of Public Health Strategy and Analysis issued an interesting (and much anticipated) report regarding Laboratory Developed Tests (LDTs). The Agency has consistently cited a need for greater oversight of LDTs out of concern for public safety. Laboratory Developed Tests used to…
Webinar Highlights | Simplifying Methods Transfer: Novel Tools for Replicating Your Established Methods on an ACQUITY Arc System I’m Dr. Paula Hong, Principal Scientist at Waters Corporation. I recently conducted a webinar that talked about the instrument characteristics that can impact transfer of established reversed-phase methods across both HPLC and UHPLC systems. These factors include dwell…
You might not like the answer… So the other day, I was with a customer when they asked me, “Viet, there are so many detectors out there! How do I know which one I need?” To which I answered with the one comment that all of you will love to hate, “It depends!” Detectors for…
Endangered analytical chemists face myriad obstacles today – lower than average job forecasts 1, costly and timely training, demand for more versatile knowledge, tighter regulations, and massive data management requirements. Perhaps most significantly, mass spectrometry market forecasts predict a lack of skilled users as a key market constraint2. Senior analytical chemists are presented with a…
Multiple attribute monitoring has become a hot topic of discussion within biopharmaceutical organizations as the methodology allows detection and measurement of more critical quality attributes than conventional methods. Waters recently sponsored an outstanding webinar on this topic, hosted by Genetic Engineering News and presented by our own Biopharmaceutical Senior Manager, Sean M. McCarthy, Ph.D. Watch…
Global trading of herbs and spices can be traced back for thousands of years. Historically they were considered a rare and precious commodity, but methods to determine their authenticity were only very basic, creating a compelling incentive to substitute with lower-value products with a low risk of the adulteration being discovered. This is clearly not…
NASA made history again recently as the spacecraft New Horizons successfully flew by Pluto, the last of the nine ‘classical’ planets, to gather valuable data about an area of our solar system that we know very little about. The spacecraft managed to successfully gather the most detailed images of Pluto ever seen whilst hurtling past…
For many years, the prevailing wisdom has been that in the event of chromatographic coelution, caused by complex samples, what is needed is a high-resolution mass spectrometer that can accurately identify different species contained within that single peak. However, even with the highest levels of resolution some ionisation patterns can be obscured by other species…
Melamine and cyanuric acid (CA) are low mass, nitrogen-rich compounds that have been linked to protein adulteration in various foodstuffs in the past.1 While melamine and cyanuric acid are not individually toxic, in combination they can sometimes form an adduct compound through hydrogen bonding, melamine cyanurate, that produce sharp crystals which can cause internal organ failure…