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Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
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Screening for Melamine, Cyanuric Acid, and Dicyandiamide in Powdered Milk and Infant Formula
Melamine and cyanuric acid (CA) are low mass, nitrogen-rich compounds that have been linked to protein adulteration in various foodstuffs in the past.1 While melamine and cyanuric acid are not individually toxic, in combination they can sometimes form an adduct compound through hydrogen bonding, melamine cyanurate, that produce sharp crystals which can cause internal organ failure...
Dispersion Matters: Rethinking How LC Systems Should be Categorized
For more than five decades, attempts have been made to improve liquid chromatography separations performance by reducing the particle size of the stationary phase. However, the benefits of doing so can only be realized if the LC instrument provides an appropriate amount of extra-column dispersion (band spreading) in relation to the volume of the column...
Is Ion Mobility Ready for Routine Use?
Sitting in the Waters’ John Dalton Suite in Wilmslow, England two weeks ago felt somewhat duplicitous. Here we were, in the part of the world considered the birthplace of Mass Spectrometry (MS), about to embark on a two-day workshop with 20 key collaborators and thought leaders to discuss Ion Mobility Spectroscopy (IMS), its use in contemporary structural...
Characterizing Extractables from Packaging Materials
Characterization of packaging in various industries has become more important due to ever-increasing global regulations. The first regulations for plastics used in food packaging and contact materials were established in 1982 in Europe1, which have been expanded in recent years.2 In the pharmaceutical field the need for extractables testing was recognized in the 1990s.3 Manufacturers...
Agro Food industry Hi Tech article: Ensuring the Consistency and Quality of Food and Beverages with New Advancements in Mass Spectrometry
by Joe Romano Joe Romano is Senior Manager of Waters’ Food and Environmental Business and a member of the AgroFood Industry Hi Tech Scientific Advisory Board In his recently published article in AGRO Food Industry Hi Tech, author Joe Romano says that in order to ensure long-term success in a highly competitive global market, food, beverage,...
Full Spectrum Molecular Imaging: More Than Just Pretty Pictures
The spatial distribution of molecules throughout a sample can provide a wealth of information regarding biological, physiological, and chemical phenomena and processes. One of the most recent and exciting developments in the study of molecular distributions has been the use of mass spectrometry (MS) to specifically measure molecular targets in order to determine their distribution...
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