-
Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
Recent Posts
High-throughput Microscale Bioanalysis is not a Paradox
Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in our group knows how to use it!” Maybe even, “there’s no way I can successfully transfer that method, so why...
Tandem Quad Mass Spectrometry: The Foundation of Product Safety, Efficacy, and Decision-making
There is a rightfully high expectation from consumers that the amounts of compounds and ingredients that producers report in their goods are accurate down to trace levels. Whether personally or professionally, we all rely on this analytical information coming from laboratories that enables critical decisions to be made. Analytical chemists have been performing quantitative studies...
WRIB 2016: Diversity of Platforms and Approaches Needed for Bioanalysts
Held April 18–22 in Lake Buena Vista, Florida, WRIB 2016 was well attended this year, with about 700 attendees. This 10th Workshop on Recent Issues in Bioanalysis, where regulators and professionals representing pharma/biopharma, biotech, CRO organizations gather to discuss challenges in method development and emerging approaches, proved as fruitful as years past. Here are a...
Simon Fraser University Opens Suite of Mass Spectrometers for Natural Products Discovery Research
As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source...
Mass Spectrometry Makes Cents for UC San Diego Clinical Laboratory
“Fast is fine; but accuracy is everything.” The quote is attributed to the famous Wyatt Earp, a sharpshooter and lawman who, with help from his two brothers, sent three outlaws to their graves in the Gunfight at the O.K. Corral in Tombstone, Arizona in 1881. One hundred and twenty five years later, Dr. Rob Fitzgerald...
What’s the big deal about ion mobility mass spectrometry?
Ion mobility spectrometry (IMS) is a technique that differentiates ions based on their size, shape, charge, and mass. While often used in small, portable devices at airports and remote locations for rapidly detecting small molecules whose mobility is known (for example, certain narcotics and explosives) when coupled with liquid chromatography-mass spectrometry (LC/MS), IMS provides an...
Popular Topics
ACQUITY QDa (17) bioanalysis (11) biologics (14) biopharma (26) biopharmaceutical (36) biotherapeutics (17) case study (17) chromatography (14) data integrity (23) food analysis (12) HPLC (15) LC-MS (22) liquid chromatography (LC) (21) mass detection (16) mass spectrometry (MS) (54) method development (13) STEM (12) sustainability (12)