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Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
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Is Your Biomedical Research Accurate and Precise?
In biomedical research, scientists need the ability to accurately and precisely measure a biomarker or set of biomarkers in some disease vs. healthy experimental design. The ability to measure something depends on the ability of the measurement methodology, including analytical tools, to accurately and precisely quantify the true value for the object of interest. Accuracy:...
Binary vs Quaternary Pumps: How is a Gradient Created?
How is a Gradient Created? Any liquid chromatograph (LC) is an amalgamation of a certain set of components that delivers to the scientist a monograph of the sample they are analyzing. Traditionally, an LC system consists of a pump, an injector, a column heater, a detector, and even more commonly these days a mass spectrometer...
Phenome Research Footprint Continues to Expand
Congratulations are in order as the University of Birmingham is the most recent university to expand the footprint of metabolic phenotyping research centres around the world. As state-of-the-art metabolic phenotyping facilities able to conduct small-scale and large-scale studies in medical research and stratified medicine, the Phenome Centre Birmingham joins the MRC-NIHR National Phenome Centre at...
An Inflection Point for Biopharmaceutical Host Cell Protein Analysis
Has LC-MS Become a Generally Accepted Tool for Complementing Immunoassay-based HCP Analysis? My colleague Catalin Doneanu and I just returned from Lisbon, Portugal, where we attended the BEBPA Conference on Host Cell Protein (HCP) analysis. Along with the other 120 attendees, we participated in open and thoughtful discussions on the best practices for HCP analysis...
Has Your Dinner Menu Been Quantified?
For decades, food security was viewed exclusively through the lens of shortages. In the 1960s, when daily food availability in emerging countries was just 1,850 kcal per person as many as half of the world’s population was malnourished. It’s easy to understand our narrow focus on increasing food production. The challenges we face have shifted....
Pumping Ions – An Exercise in Engineering Sensitivity Into the Xevo TQ-XS Mass Spectrometer
The challenge: Create the most sensitive mass spectrometer for quantitative analysis. That’s a tall order for any design engineering team. When given that assignment for a next-generation, tandem quadrupole mass spectrometer, our design engineers first spoke to those for whom analytical sensitivity means the most: scientists doing quantitative studies for demanding clients relying on accurate...
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