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Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
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How Analytical Technologies Support the Development of Biosimilar Drugs
Advancements in High-Resolution Analytics for the Characterization of Innovator and Biosimilar Therapeutics As the pharmaceutical industry continues to evolve its focus from small-molecule drugs to balanced product portfolios that include protein therapeutics, analytical chemists are increasingly challenged to produce routine and automated characterization workflows that move innovator and biosimilar biopharmaceutical products forward through development and...
Advancing Omics Research and Reducing Bias with New MS Technology for Data-Independent Acquisition Experiments
Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding of biological systems in terms of drug development and treatment. Understanding the context of analytical results is driving current research,...
Phenome Network: A Harmonized Research Consortium for Innovative Global Health
The world is facing an unprecedented convergence of environmental and lifestyle factors that dramatically increase our risk of chronic disease. Global warming, antimicrobial resistance, aging populations, and the prevalence of lifestyle-related illnesses are systematically affecting populations around the world and posing some of the greatest scientific and public health threats seen in modern times. These...
Detecting Bisphenol A (BPA) in Infant Products with Mass Spec
Developing a Rapid, Routine Method for Extraction and Quantification in Complex Infant Products with UPLC/MS-MS Bisphenol A (BPA) is an additive that is primarily used in the production of polycarbonate plastics and epoxy resins. These synthetic materials are widely used in packaging to protect the safety and integrity of foods and beverages. Polycarbonates are used...
Infographic: Large Molecules Have a 2X Greater FDA Approval Rate Than Small Molecule Drugs
It’s no surprise that pharma is ‘Thinking Large’ Large molecules are dominating pharma sales and FDA approvals. At the end of 2015, seven of the top 10 best-selling prescription drugs were large molecules. According to a 2014 article in Nature, the overall approval rate for small and large molecule therapeutics is nearly 10% (comprised of lead and secondary...
Tips to maintain your HPLC & UHPLC systems and columns
Recently, Ade Kujore (Cecil Instruments), Tracie Brombos (GenTech Scientific), and I were asked by Angelo De Palma, a well-respected writer for Lab Manager magazine, to contribute to an article about maintaining and caring for your laboratory instruments. Here are my tips and best practices for column and HPLC, UHLPC, and UPLC system maintenance. Maintaining your...
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