-
Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
Recent Posts
Ultra-Pure Proof with Mass Detection
At Reach Separations, they're putting robust detection on the front lines of method development and mass confirmation.
Infographic: Simplifying the Screening Workflow for Extractables Testing
How to design an analytical workflow to screen for extractables and leachables The safety of pharmaceuticals, cosmetics, and foodstuffs may be compromised by chemical compounds in the various types of packaging and food contact materials (FCMs) that are in direct contact with the consumer product. Due to continuously increasing global regulations, the characterization of extractables...
Mission Improbable: Rapid Total Sugar Reporting for Beer by Mass Detection
Lion, one of the largest food and beverage companies in Australia and New Zealand, wanted to monitor fermentation profiles to completion as the company introduced voluntary nutritional panels across its beer portfolio. See what they gained by changing from electrochemical to mass detection.
A CRO Leads the Way for Biotherapeutics Amid its Own ‘Field of Dreams’
“If You Build it, He Will Come” Urged on by a voice no one else could hear, Ray Kinsella, played by Kevin Costner in the movie Field of Dreams, cleared a few acres of corn to build a baseball field. Shortly after, magical things began to happen. When you first set eyes on the headquarters...
Analytical Tools for Developing Biosimilars: Part 3, Glycosylation, Aggregation, and Charge Variants
In biotherapeutics, the state of glycosylation has a direct and pronounced effect of the structure, stability, serum half-life, immunogeneicity and bioactivity of the molecule, and constitutes a critical quality attribute (CQA). In our study, characterizing and comparing the glycosylation profile of infliximab began by examining the glycosylation profiles from intact and reduced subunit mass data.
Analytical Tools for Developing Biosimilars: Part 2, Peptide Analysis
Advancements in High-Resolution Analytics for Characterization of Innovator and Biosimilar Therapeutics Part 2: Peptide Analysis of Infliximab
Popular Topics
ACQUITY QDa (17) bioanalysis (11) biologics (14) biopharma (26) biopharmaceutical (36) biotherapeutics (17) case study (17) chromatography (14) data integrity (23) food analysis (12) HPLC (15) LC-MS (22) liquid chromatography (LC) (21) mass detection (16) mass spectrometry (MS) (54) method development (13) STEM (12) sustainability (12)