-
Slalom Chromatography: A High-Speed Path to Nucleic Acid Separation
Slalom chromatography is no longer just a scientific curiosity, it’s a comeback story. Once sidelined due to limited reproducibility and unclear mechanisms, this technique is now gaining momentum thanks to the rise of nucleic acid therapeutics and advances in UHPLC systems. But its revival wasn’t accidental. It took a year-long deep dive into DNA physics,…
Recent Posts
NASA’s New Horizons set the standards, Waters Xevo users benefit
NASA made history again recently as the spacecraft New Horizons successfully flew by Pluto, the last of the nine ‘classical’ planets, to gather valuable data about an area of our solar system that we know very little about. The spacecraft managed to successfully gather the most detailed images of Pluto ever seen whilst hurtling past...
Ion mobility: Providing better answers for age-old problems
For many years, the prevailing wisdom has been that in the event of chromatographic coelution, caused by complex samples, what is needed is a high-resolution mass spectrometer that can accurately identify different species contained within that single peak. However, even with the highest levels of resolution some ionisation patterns can be obscured by other species...
Screening for Melamine, Cyanuric Acid, and Dicyandiamide in Powdered Milk and Infant Formula
Melamine and cyanuric acid (CA) are low mass, nitrogen-rich compounds that have been linked to protein adulteration in various foodstuffs in the past.1 While melamine and cyanuric acid are not individually toxic, in combination they can sometimes form an adduct compound through hydrogen bonding, melamine cyanurate, that produce sharp crystals which can cause internal organ failure...
Dispersion Matters: Rethinking How LC Systems Should be Categorized
For more than five decades, attempts have been made to improve liquid chromatography separations performance by reducing the particle size of the stationary phase. However, the benefits of doing so can only be realized if the LC instrument provides an appropriate amount of extra-column dispersion (band spreading) in relation to the volume of the column...
Is Ion Mobility Ready for Routine Use?
Sitting in the Waters’ John Dalton Suite in Wilmslow, England two weeks ago felt somewhat duplicitous. Here we were, in the part of the world considered the birthplace of Mass Spectrometry (MS), about to embark on a two-day workshop with 20 key collaborators and thought leaders to discuss Ion Mobility Spectroscopy (IMS), its use in contemporary structural...
Characterizing Extractables from Packaging Materials
Characterization of packaging in various industries has become more important due to ever-increasing global regulations. The first regulations for plastics used in food packaging and contact materials were established in 1982 in Europe1, which have been expanded in recent years.2 In the pharmaceutical field the need for extractables testing was recognized in the 1990s.3 Manufacturers...
Popular Topics
ACQUITY QDa (17) bioanalysis (12) biologics (14) biopharma (27) biopharmaceutical (37) biotherapeutics (18) case study (18) chromatography (14) data integrity (23) food analysis (12) HPLC (15) LC-MS (23) liquid chromatography (LC) (23) mass detection (16) mass spectrometry (MS) (58) method development (13) STEM (12) sustainability (12)