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Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in our group knows how to use it!” Maybe even, “there’s no way I can successfully transfer that method, so why…
There is a rightfully high expectation from consumers that the amounts of compounds and ingredients that producers report in their goods are accurate down to trace levels. Whether personally or professionally, we all rely on this analytical information coming from laboratories that enables critical decisions to be made. Analytical chemists have been performing quantitative studies…
Ion mobility spectrometry (IMS) is a technique that differentiates ions based on their size, shape, charge, and mass. While often used in small, portable devices at airports and remote locations for rapidly detecting small molecules whose mobility is known (for example, certain narcotics and explosives) when coupled with liquid chromatography-mass spectrometry (LC/MS), IMS provides an…
The quality issues of biopharmaceutical therapeutics are definitely different from chemical drugs because of the increased complexity of manufacturing processes and complexity of the biologic molecules themselves. There is an increasing need for detailed product characterization and control of the manufacturing process. Sheng Hou et.al. have developed and validated a practical, cost efficient, robust adalimumab…
Interest in ion mobility mass spectrometry (IMS) technology is growing rapidly. The signs are everywhere. Since the year 2000, the number of abstracts submitted to ASMS mentioning ion mobility has grown more than 10-fold – from 30 to more than 350 in 2015. For most of that time, ion mobility has been available commercially in…
As regulators focus in on the critical quality attributes of biotherapeutics, what can biopharmaceutical labs in late development or QC do to increase confidence in their bioseparations – other than to run more assays?
The thought of transferring established high performance liquid chromatography (HPLC) methods onto a another vendor’s LC, or a new platform like UHPLC/UPLC, may cause a bit of anxiety for those that may be unaware of how easy it can be. The reason that the topic of analytical method transfer induces so much angst is that…
According to published reports by Hiscox UK in 2008, just listening to the sound of a sports car increased salivary testosterone levels in male and female participants. Another study, by Gad Saad et al, measured a testosterone increase in men who were given the opportunity to drive a $150,000 Porsche 911 Carrera Cabriolet for an…
Tea is very important to them! If Waters Wilmslow ran out of tea it is likely the MS Research Team would struggle to function. The ancient Chinese Ruler, Emperor Jing Di, took tea to the grave with him for a cuppa in the afterlife. Many treasures were found in his tomb including; food, weapons, ceramic animals,…
What can you get all the top Pharma and CRO’s scientists to agree on? That the biopharma industry is growing and quantifying biotherapeutics for bioanalysis is difficult – but you have options.
On Wednesday evening after dinner and my usual digestif, I was watching the webcast “Making Ion Mobility Mass Spectrometry Routine” when my son walked by. “Wow dad, that’s kind of cool! What the heck is it?” he asked. “It’s ion mobility!! It’s an orthogonal and complementary resource for chromatography and mass spectrometry…” The digestif was…
Webinar Highlights | Understanding the Impact of System Dispersion on Separation Performance Hi, I am Jonathan E. Turner, Product Marketing Manager for ACQUITY® UPLC® and CORTECS® lines of columns at Waters Corporation. I recently conducted a webinar that talked about the changes we have seen the last 10 years and the substantial improvements in both…