Technology

Our expertise drives innovation, development, and application of informatics and software that continue to enable leading pharmaceutical, environmental, food & beverage and chemical materials organizations to accelerate decision-making, improve laboratory effectiveness, and get products to market faster.

  • Comprehending COVID-19: How Consumables Can Increase LC-MS/MS Sensitivity

    During 2020, we collaborated with many of our customers to develop targeted liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) methods to detect SARS-CoV-2 (the virus that causes COVID-19) from biological samples. However, the combination of the biological specimen, the sample collection medium, the viral load threshold, and the need for a high throughput method gave rise to…

  • Answering the Call with Compliance-Ready LC-MS Solutions for Oligonucleotide Analysis

    Oligonucleotides, or short strands of DNA or RNA, continue to increase in popularity. In addition to their essential role as primers and probes in the expanding clinical DNA testing and diagnostics market, they’re also seeing great success as new gene-based therapeutics that hold tremendous promise. With a string of recent drug approvals, including the first…

  • Tools for Chromatographic Success: Three Ways to Support Data Quality in Routine Analysis

    Avoiding the pitfalls of data quality and integrity in the Pharma QC laboratory while running routine analyses is an ongoing challenge. Regulatory violations are frequently a result of a lack of complete data, suspect data, and improper audit trails. A recent report from Deloitte stated that data integrity violations account for over 70% of the…

  • Boosting Biopharma Productivity with Routine LC-MS

    As scientific advances continue to carry researchers into new arenas, it is vital that technology evolves in tandem. At Waters, we understand that it is only by leveraging fit-for-purpose technologies that researchers are able to unleash their creativity and make pioneering scientific breakthroughs. Scientists working within the rapidly growing biopharmaceutical industry are no exception. With…

  • USEPA Approves APGC Tandem Quadrupole Mass Spectrometry as Alternative Test Procedure for Dioxin Analysis

    A Breakthrough in Dioxin Analysis for Environmental Laboratories In September, the United States Environmental Protection Agency (USEPA) recognized the use of atmospheric pressure gas chromatography (APGC) with tandem quadrupole mass spectrometry (MS) as an acceptable alternative to traditional high-resolution magnetic sector mass spectrometry for USEPA Method 1613. The recognition frees laboratories to adopt the Waters…

  • Need to Improve Database Scoring for LC/MS Metabolomics? Try ACQUITY Premier Columns!

    After another wrong assignment, I knew there had to be a better way to improve my database matching! Spectral library matching is an integral component in the workflow of untargeted, or high resolution mass spectrometry, analyses such as urine or plasma metabolomics. The comparison of non-disease and disease state samples can give insights to potential…

  • Ready for What’s Next in Your Lab?

    In this series, we review considerations for keeping your lab at the forefront of science. As you adjust to living and working in a pandemic and anticipate future global and geopolitical events, Waters remains dedicated to supporting your business and unlocking the potential of your science. Our holistic separations solutions and expert support help you…

  • Waters ACQUITY Premier Columns: A New Solution for Sample Loss of Metal-Sensitive Analytes

    Why do we lose compounds while trying to measure them? Are they disappearing? Are they breaking down? Why and how? It all starts with adsorption and for certain metal-sensitive analytes, it renders chromatographic analysis using stainless steel columns a significant chore. Thankfully, Waters engineers have created an elegant solution to this widely experienced, yet lesser…

  • Chords and Chemistry and the Benefits of Choosing Wisely

    “A true measure of excellence for Waters is in orchestrating consistent instrument and chemistry optimization across applications, methods, and workflows.” I was on a job interview – more specifically, for my first position at Waters – where I was asked a compelling question. The question had to do with the consideration that Waters was a…

  • In Need of Some Reversed Phase Polar Acid Relief

    Retaining polar analytes using reversed phase (RP) chromatographic conditions have long frustrated scientists.  Trying to promote interactions between polar analytes and a non-polar reversed phase surfaces can often bring the most experienced separation scientist to their breaking point. Polar acids specifically present their own set of challenges that make them particularly difficult to retain under…

  • Bring efficiency back to your lab: How aging technology hinders ideal performance

    In this series, we review considerations for keeping your lab at the forefront of science. As we adjust to living and working in a pandemic and anticipate future global and geopolitical events, Waters remains dedicated to supporting your business and unlocking the potential of your science. Our holistic separations solutions and expert support help you…

  • Addressing the Mystery of Sample Loss

    Many years ago, I was hired by a biopharma company to develop analytical methods for therapeutic oligonucleotides. When a new colleague warned me about sample loss on LC columns I looked at him with skepticism. “Yes,” he insisted, “part of your DNA sample may be irreversibly bound to the column and you will never see…