Where Did My Sample Go?
Non-specific binding of protein and peptides continues to plague scientists with low recovery. high variability, and poor sensitivity. Are you doing enough to combat non-specific binding?
When Resolving Minor Differences in Protein Therapeutics Can Have a Major Impact
Scientists from Waters and Pfizer collaborated to take on the challenge of engineering a novel reversed-phase LC column for high-throughput separations with enhanced resolution, selectivity, and recovery of target mAbs and ADCs.
I Resolve to Get Better mAb Separations
We listened and learned how scientists separate mAbs and ADCs; then we designed a novel column for LC-MS bioseparations A critical step toward the prolific and successful use of monoclonal antibodies (mAb) as biotherapeutics occurred in 1988 when techniques were introduced to humanize these biomolecules, eliminating or reducing the deleterious patient side effects that previous…
Setting a New Standard for Reserved-Phase Separations of Monoclonal Antibodies and Antibody Drug Conjugates
A new approach to stationary phase chemistry for reversed-phase LC analysis of proteins, including monoclonal antibodies and antibody drug conjugates, delivers higher fidelity data especially for MS-based peak identification.
A CRO Leads the Way for Biotherapeutics Amid its Own ‘Field of Dreams’
“If You Build it, He Will Come” Urged on by a voice no one else could hear, Ray Kinsella, played by Kevin Costner in the movie Field of Dreams, cleared a few acres of corn to build a baseball field. Shortly after, magical things began to happen. When you first set eyes on the headquarters…