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Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
Recent Posts
Molecular Visualization: Mass Spec Imaging Delivers Insights for Cancer Research
How does mass spectrometry (MS) imaging provide a molecular image that can be used for the biochemical characterization of histological images? A rapidly developing technique for clinical research, MS imaging enables investigation of the spatial distribution of molecules at complex surfaces. It’s a direct-from-sample analytical technique that provides researchers with the information needed to quickly...
Mass detection and mAb QC: How a cost-effective and robust peptide mapping method confirms CDR peptides – and can be validated
The quality issues of biopharmaceutical therapeutics are definitely different from chemical drugs because of the increased complexity of manufacturing processes and complexity of the biologic molecules themselves. There is an increasing need for detailed product characterization and control of the manufacturing process. Sheng Hou et.al. have developed and validated a practical, cost efficient, robust adalimumab...
A View of the Biopharmaceutical Industry in Asia — an Interview with Ken Fountain
Ken Fountain, Director of Biopharmaceutical Business Development at Waters, recently returned from an insightful trip to Asia where he visited Waters customers in South Korea and attended the China Biopharma Executive Summit in Shanghai, in which Waters was a sponsor. We caught up with him and asked him to share his thoughts about the biopharmaceutical...
Metabolic Blurred Lines: Is Biotransformation the next Met ID?
You are the hunter in a landscape of scientific gatherers, the stealthy SEAL of DMPK, the nimble ninja of ADME. You are a Metabolite ID scientist. Traditionally, Met ID labs have been a fixture of any pharmaceutical company worth its salt. Now, imagine that your proud band of comrades has been phased out, split...
Separations Science Guiding Disease Research at Colorado State University
As infectious diseases go, tuberculosis (TB) is clearly one of the worst. Easily spread through the air by those with an active infection, it is a scourge that is decimating developing countries. The World Health Organization (WHO) estimates that, in 2014, 9.6 million people fell ill with the disease and 1.5 million died, with 95%...
Ion Mobility Mass Spectrometry – Catch the Excitement!
Interest in ion mobility mass spectrometry (IMS) technology is growing rapidly. The signs are everywhere. Since the year 2000, the number of abstracts submitted to ASMS mentioning ion mobility has grown more than 10-fold – from 30 to more than 350 in 2015. For most of that time, ion mobility has been available commercially in...
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