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Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
Recent Posts
Multi-Attribute Monitoring: The Expanding Role of Mass Spectrometry for mAb Subunit Analysis
Two MAM approaches for biotherapeutic analysis are being implemented today; one focused on the analysis of monoclonal antibody (mAb) subunits, and the other focused on the analysis of peptides from a protein digest (peptide mapping workflow). Both have their advantages and disadvantages. Here, we explore MAM for mAb subunit analysis.
How to Detect Fipronil in Eggs: Tips for Pesticide Screening Laboratories
We discuss analytical options using LC and GC with MS/MS to detect the pesticide fipronil in eggs for food safety testing.
How to improve analytical method transfers for biotherapeutics
“Assuming continuous improvement is a worthy goal, there is every reason to improve validated chromatographic methods if you’re working with the right instrument technology,” says Eric Grumbach of Waters. See what that means for developing and transferring methods for biologic drugs.
Setting a New Standard for Reserved-Phase Separations of Monoclonal Antibodies and Antibody Drug Conjugates
A new approach to stationary phase chemistry for reversed-phase LC analysis of proteins, including monoclonal antibodies and antibody drug conjugates, delivers higher fidelity data especially for MS-based peak identification.
Columns Matter, Too: Choosing Optimal Conditions for Trap-and-Elute Nanoflow and Microflow LC-MS
Considerations for optimizing trapping conditions, such as flow rate and trapping volume, in nanoscale and microflow LC-MS.
UPLC Chromatography Gets an Update: Because Science Never Quits
We've updated our UPLC systems to enable you to find faster, simpler, and better ways to do your work. Take a closer look at our new and improved ACQUITY UPLC PLUS Series.
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