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Slalom Chromatography: A High-Speed Path to Nucleic Acid Separation
Slalom chromatography is no longer just a scientific curiosity, it’s a comeback story. Once sidelined due to limited reproducibility and unclear mechanisms, this technique is now gaining momentum thanks to the rise of nucleic acid therapeutics and advances in UHPLC systems. But its revival wasn’t accidental. It took a year-long deep dive into DNA physics,…
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How Advances in Bioanalysis Drive Scientific and Ethical Progress
How Sygnature Discovery Supports the 3Rs with LC-MS/MS Scientific Precision and Ethical Innovation In the world of drug discovery, researchers face a critical challenge: how do you generate high-quality, reproducible bioanalytical data while minimizing the ethical and logistical burden of using animals in testing? This is especially so with central nervous system (CNS) drug discovery,...
Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with...
Protecting Your Laboratory Data: Cybersecurity at Waters
With the ever-present threat of cyberattacks, safeguarding laboratory data has become a top priority for scientists across the globe. Many labs are accelerating digitalization efforts, but that could expose their data to greater risks. The Increase in Lab Digitalization: Effects on Cybersecurity As it turns out, the increase in digitalization, particularly the shift to the...
Charge Detection Mass Spectrometry (CDMS): Unprecedented Direct Measurement for the Characterization of Mega-Mass Biomolecules
Whether you are analyzing adeno-associated viruses (AAVs) or virus-like particles, nucleic acids such as RNAs or lipid nanoparticles (LNPs), proteins, or protein complexes, simple and fit-for-purpose tools with speed, accuracy, and precision are essential for driving biotherapeutic innovations forward. In recent years, scientists have increasingly turned to charge detection mass spectrometry (CDMS).
OligoWorks SPE Kits: Boosting Oligonucleotide Bioanalysis Efficiency
New OligoWorks Solid Phase Extraction (SPE) Kits for extraction and bioanalysis of oligonucleotides deliver advantages over liquid-liquid extraction (LLE) and other existing SPE kits and sample preparation methods. Read on to discover how.
Increasing Lab Efficiency with Amazon Web Services to Enable Real-Time Remote Access to Lab Information
The collaboration between Waters and AWS has enhanced the waters_connect System Monitoring tool, revolutionizing laboratory productivity. This cloud-based platform provides secure, compliant access to chromatography lab information, allowing users to coordinate work, address system errors, and make informed decisions from anywhere, anytime.
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