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Improving, Retaining, and Separating Polar Compounds Using Chromatographic Techniques
Separating and retaining polar compounds are significant challenges in chromatography. Here, we explore the key technical considerations and solutions for effectively handling these compounds, focusing on advanced chromatographic techniques and column technologies. What Are Polar Compounds? Polar compounds are essential in biological processes, drug design, and industrial applications due to their ability to interact with…
Recent Posts
Traceability in OneLab: Tracking the Analyst’s Completion of an Experiment
Bring increased confidence in sample preparation workflows with OneLab, which enables you to track a lab analyst’s completion of an experiment. Read this blog post, revised in September 2023 to include the most up-to-date information, to learn more!
Stronger Together Against COVID-19
At Waters, we have a long history of working alongside the scientific community in times of need through collaboration. Today, as the world continues to battle COVID-19, that collaborative approach is more important than ever. Ultimately, this challenge is far too great for any organization to tackle alone. That is why we created the Waters COVID-19 Innovation Response Team. In the early...
Waters GlycoWorks RapiFluor-MS N-Glycan Kit Improves Reproducibility and Speed of N-Glycan Analysis Through Innovation and Automation
Glycosylation is an important post-translational modification that can impact the safety and efficacy of protein therapeutics and is therefore one of the most analyzed product attributes during development and quality control. In released N-glycan analysis, glycans are cleaved from proteins via enzymatic digestion and are chemically derivatized for relative quantification by liquid chromatography coupled to fluorescence and mass spectrometry, or capillary electrophoresis with laser-induced fluorescence detection. The inherent challenges of N-glycan analysis have pushed the industry to improve upon...
Serving Our Customers Through a Pandemic
Early on in the pandemic, Adam Beard, Waters’ Vice President of Global Services, wrote about how our employees were “Delivering Benefit While Supporting the Front Lines of a Global Pandemic” in a post on LinkedIn. Today, that critical work continues. Recently, we spoke to some of our colleagues from our global service and manufacturing teams that...
The Impact of Complex Global Supply on the Nitrosamine Crisis
When a crisis occurs, hindsight is a great teacher. Any company developing or manufacturing products that impact human health can learn from the recent nitrosamine impurity contamination of angiotensin II receptor blockers (ARBs) by reviewing their own quality processes for risks that could result in a similar contamination issue. Analytical data should assure confidence in...
Choosing the Correct Column for Chromatographic Selectivity
When developing a method for the routine multiresidue analysis of pesticides in food commodities there are several factors that need to be considered when selecting which liquid chromatography (LC) column to use. The requirements include: Good retention for a range of physiochemical properties (polar, non-polar, base, acid). Moderate to high resolution (peak capacity). Sample extracts...
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