GLP-1 Receptor Agonists

 GLP-1 Receptor Agonists

Streamline your workflows, from characterization to purification and QC, to accelerate the development of safe and effective GLP-1 RA therapies with Waters. Our comprehensive and robust solutions help you simplify the process, ensure high-quality results, reduce uncertainty, and advance your path from discovery to patient use.

Streamline your workflows, from characterization to purification and QC, to accelerate the development of safe and effective GLP-1 RA therapies with Waters. Our comprehensive and robust solutions help you simplify the process, ensure high-quality results, reduce uncertainty, and advance your path from discovery to patient use.

GLP-1 RA Molecule
GLP-1 RA Molecule

Overview

The journey of a GLP-1 receptor agonist (GLP-1 RA) molecule is complex. From discovery to quality control, and ultimately the delivery of safe, high-quality GLP-1 RA drugs, each stage in the molecule’s journey presents unique challenges.

Waters comprehensive workflow solutions are built to simplify this journey. By delivering robust, reproducible methods, minimizing analytical uncertainty, and accelerating development timelines, Waters helps you navigate every critical step with greater speed and confidence so your molecule can reach patients faster and safer.


Applications

GLP-1 receptor agonist manufacturers need sensitive and reliable methods to perform raw material screening, impurity characterization, stability monitoring and lot release testing. Explore how you can improve impurity assay sensitivity by 50% when developing methods with MaxPeak™ high performance surfaces as compared to traditional stainless-steel hardware.

GLP-1 receptor agonist manufacturers need sensitive and reliable methods to perform raw material screening, impurity characterization, stability monitoring and lot release testing. Explore how you can improve impurity assay sensitivity by 50% when developing methods with MaxPeak™ high performance surfaces as compared to traditional stainless-steel hardware.


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Scientists developing targeted quantitation assays supporting pharmacokinetics or bioequivalence studies require accurate and precise measurement of GLP-1 RA drug concentrations. However, non-specific binding (NSB) can be a major source of method variability. Discover a new workflow that improve GLP-1 RA recovery by 5x and yields accurate quantitative results down to .12 ng/mL.

Scientists developing targeted quantitation assays supporting pharmacokinetics or bioequivalence studies require accurate and precise measurement of GLP-1 RA drug concentrations. However, non-specific binding (NSB) can be a major source of method variability. Discover a new workflow that improve GLP-1 RA recovery by 5x and yields accurate quantitative results down to .12 ng/mL.


Human blood serum sample in tube in lab

Researchers developing lab scale purification methods to isolate GLP-1 RA drug substances can be challenged when dealing with small collection volumes and closely related impurities. Low-dispersion fraction collection modules enables the collection of narrow UPLC peaks, improving your ability to obtain high purity fractions when working with low sample amounts.​

Researchers developing lab scale purification methods to isolate GLP-1 RA drug substances can be challenged when dealing with small collection volumes and closely related impurities. Low-dispersion fraction collection modules enables the collection of narrow UPLC peaks, improving your ability to obtain high purity fractions when working with low sample amounts.​


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Accurate, traceable data is vital in QC and GxP labs. Waters delivers a complete QC solution with robust LC systems, trustworthy columns, and advanced detectors such as MS and MALS, enabling identity verification, impurity analysis, and native oligomeric state characterization within the compliance-ready Empower Software ecosystem. 

Accurate, traceable data is vital in QC and GxP labs. Waters delivers a complete QC solution with robust LC systems, trustworthy columns, and advanced detectors such as MS and MALS, enabling identity verification, impurity analysis, and native oligomeric state characterization within the compliance-ready Empower Software ecosystem. 


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Podcast: Advancements and Challenges in GLP-1 Peptide Drugs

This episode of Chromatography Life takes a closer look at the evolving landscape of synthetic peptide drugs - one of the most compelling frontiers in biopharmaceutical analysis. Join Matt Lauber, Senior Director at Waters and recognized authority in bioanalysis and drug product characterization, who shares his personal and professional journey and insights into the science shaping today’s peptide therapeutics. We discuss the growing significance of GLP-1 peptide drugs, their analytical hurdles, and chromatographic techniques to help ensure their safety and effectiveness. Whether you're already immersed in the world of drug development or peptide-curious, this conversation provides the right dose of thoughtful perspective on how innovation and precision are changing the future of human health.

This episode of Chromatography Life takes a closer look at the evolving landscape of synthetic peptide drugs - one of the most compelling frontiers in biopharmaceutical analysis. Join Matt Lauber, Senior Director at Waters and recognized authority in bioanalysis and drug product characterization, who shares his personal and professional journey and insights into the science shaping today’s peptide therapeutics. We discuss the growing significance of GLP-1 peptide drugs, their analytical hurdles, and chromatographic techniques to help ensure their safety and effectiveness. Whether you're already immersed in the world of drug development or peptide-curious, this conversation provides the right dose of thoughtful perspective on how innovation and precision are changing the future of human health.


Solutions


Analysis and Characterization

Analysis and Characterization

Optimized UPLC performance for reliable peptide analysis

Optimized UPLC performance for reliable peptide analysis

The ACQUITY Premier UPLC System delivers exceptional sensitivity, reproducibility, and throughput, making it the ideal platform for the development and validation of GLP-1 receptor agonists.

  • 杂质表征
  • Stability Testing
  • 聚集体分析

Complete coverage for confident characterization

Complete coverage for confident characterization

The Xevo G3 QTof is a high-performance quadrupole time-of-flight mass spectrometry system, designed to deliver comprehensive qualitative and quantitative analysis—including sensitive detection of peptides like GLP-1 RAs. Its advanced ion optics and StepWave XS ion guide optimize transmission of low-mass, labile molecules, ensuring reliable results even in complex biological matrices.

Whether you're analyzing small molecules, biotherapeutics, or peptide hormones, the Xevo G3 QTof supports workflows from early discovery through development and quality control. Seamless integration with waters_connect enables secure, scalable data management, making it a powerful, flexible platform for modern analytical laboratories.

  • Impurity Characterization
  • 序列确认

Ensure confident method transfer with quality chromatography

Ensure confident method transfer with quality chromatography

Know that your GLP-1 RA formulation is consistent and, when necessary, your impurities diagnosed without question with the quality and integrity of the Arc Premier LC System for confident results.

  • 杂质表征
  • 聚集体分析

Streamline GLP-1 RA impurity and stability analysis

Streamline GLP-1 RA impurity and stability analysis

Simplify impurity analysis and stability monitoring of GLP-1 RA analogs with integrated mass detection using the compact, QC-friendly ACQUITY QDa II Mass Detector.

  • 杂质确认
  • Forced Degradation
  • 成分确认

Identify oligomers in native buffer from research to QC

Identify oligomers in native buffer from research to QC

Couple the DAWN MALS Detector to SEC to measure in solution and determine the identity and absolute molar mass of species typically difficult to characterize by mass spectrometry.

  • 聚集体鉴定

Accelerate formulation screening from weeks to hours

Accelerate formulation screening from weeks to hours

Rapidly assess aggregation and colloidal stability in automation-ready 96-, 384-, and 1536-well plates using DLS and SLS, with as little as 4 µL per well with the DynaPro Plate Reader DLS/SLS.

  • 粒径分布
  • Particle Concentration

Targeted Bioanalysis

Targeted Bioanalysis

Quantitate with absolute power and eXtreme robustness

Quantitate with absolute power and eXtreme robustness

Gain absolute confidence to make powerful decisions, reach lower limits of quantitation, and maintain optimum sensitivity for longer with the Xevo TQ Absolute XR Mass Spectrometer.

  • GLP-1定量分析

Lab-Scale Purification

Lab-Scale Purification

Purify your compounds with confidence

Purify your compounds with confidence

Achieve predictable and reliable purification outcomes with Waters flexible and scalable preparative LC solutions, including UV-based and MS-based purification systems from analytical scale to preparative scales.

  • Peptide Purification

Quality Control & Manufacturing

Quality Control & Manufacturing

Precision monitoring for GLP-1 RA manufacturing excellence

Precision monitoring for GLP-1 RA manufacturing excellence

Waters PATROL UPLC Process Analysis System delivers real-time PAT for GLP-1 RA manufacturing, ensuring precision, compliance, and control in peptide production for diabetes and obesity therapies.

  • 集成杂质分析

Reliable and high-throughput QC for GLP-1 RA production

Reliable and high-throughput QC for GLP-1 RA production

Ensure consistent peptide recovery and precise GLP-1 RA batch release testing in regulated environments with the Alliance iS Bio HPLC System and its robust, bio-inert fluid paths.

  • 杂质表征
  • 聚集体分析

Waters software streamlines data acquisition, processing, and reporting GLP-1 testing results.

Waters software streamlines data acquisition, processing, and reporting GLP-1 testing results.

Elevate your chromatography with the universal language of the lab

Elevate your chromatography with the universal language of the lab

Analyze samples and generate meaningful results effortlessly with Waters Empower Software Solutions, the industry-leading easy-to-use chromatography data system that helps you minimize training, eliminate manual labor, and increase productivity.

  • Characterization
  • Quality control and Compliance

A networked infrastructure from development to QC

A networked infrastructure from development to QC

Generate high resolution mass spectrometry data with waters_connect Informatics Platform, an app-based, compliant-ready environment to manage multiple systems on a single network, enable method sharing and data review with the scalability to meet your future lab requirements.

  • Characterization
  • Quality control and Compliance

Quality columns to support your success.

Quality columns to support your success.

Get superior size-based separations of glucagon-like peptides

Get superior size-based separations of glucagon-like peptides

Size-exclusion chromatography (SEC) is a powerful technique for important size-based analyses of GLP-1 receptor agonists. MaxPeak Premier with High-Performance Surfaces (HPS) Technology reduces secondary interactions in SEC for accurate determination of high molecular weight products (HMWPs) and reproducible, high-resolution separations. MaxPeak Premier SEC Guards extend column life without sacrificing desired resolution and performance.

  • 聚集体分析

Simplify peptide isolation and purification

Simplify peptide isolation and purification

Scale the optimized RP analytical separation on Waters Peptide OBD Columns that can repeatedly deliver high-purity peptide product yields due to the outstanding stability of our RP particles packed in our OBD hardware.  Achieve efficient lab scale peptide purifications with reduced costs.

  • Peptide Purification

Ultimate peak capacity, wide pH-stability, and increased retention for GLP-1 receptor agonists

Ultimate peak capacity, wide pH-stability, and increased retention for GLP-1 receptor agonists

Increase sensitivity for GLP-1 receptor agonists with MaxPeak Premier Peptide Columns, designed to minimize adsorption of acidic peptides (e.g., deamidated or phosphorylated) in optical and/or mass-based detection methods. Vanguard FIT Guards extend column life while maintaining peak shape, resolution, and efficiency. Available in multiple chemistries to accommodate different pH ranges to address your applications.

  • 杂质表征

Develop a peptide separation in days, not weeks

Develop a peptide separation in days, not weeks

Achieve simple reversed-phase method development for peptides with Waters MaxPeak Premier Peptide Reversed-Phase Column Method Development Screening Kit. The kit includes a step-by-step guidance insert card to obtain a reasonable separation of 80% of your peptide sample mixtures in as few as 3 days. The two MaxPeak Premier Peptide Reversed-Phase Columns and standard were carefully selected to obtain desired component resolution by changing the separation selectivity.

  • 杂质表征

Reach the highest level of performance with Waters quality consumables.

Reach the highest level of performance with Waters quality consumables.

Sensitive, robust, and reproducible results

Sensitive, robust, and reproducible results

Obtain fast, reliable extraction of GLP-1 RAs with Oasis HLB µElution Plates, designed to minimize peptide loss and support sensitive LC-MS quantitation.

  • 定量生物分析
  • GLP-1样品前处理

Prevent unwanted secondary interactions and sample loss

Prevent unwanted secondary interactions and sample loss

Mitigate GLP-1 RA sample losses from non-specific binding (NSB) with QuanRecovery Vials and Plates. Designed for recovery, sensitivity, and reproducibility, these consumables minimize analyte-surface interactions with MaxPeak High Performance Surfaces (HPS) Technology.

  • 定量生物分析
  • GLP-1样品前处理

Benchmark and validate your peptide columns with ease

Benchmark and validate your peptide columns with ease

Verify your column performance upon receipt and monitor column condition over column lifetime to save valuable research and development time with Waters MassPrep Peptide Standards.

  • GLP-1系统适应性

Achieve quick, clean, and complete digestion

Achieve quick, clean, and complete digestion

Obtain orthogonal mass information on forced degradation impurities generated via oxidation, pH, and thermal stress with RapiZyme Trypsin, a rapid 30-minute enzymatic treatment.

  • 序列确认

Accurate amino acid composition analysis

Accurate amino acid composition analysis

Obtain accurate identification and quantification of amino acids with AccQ•Tag , a pre-column derivatization method and set of reagents for amino acid analysis (AAA) including hydrolyzed GLP-1 receptor agonists.

  • 成分确认

Gain efficiency and walk away time with verified lab automation solutions.

Gain efficiency and walk away time with verified lab automation solutions.

Enhance sample prep efficiency and throughput

Enhance sample prep efficiency and throughput

Streamline sample preparation for LC-MS analyses with verified workflows that help minimize variability, improve traceability, and simplify method transfer.

  • GLP-1样品前处理

Ensure uninterrupted GLP-1 RA analysis with industry leading service and support 

Ensure uninterrupted GLP-1 RA analysis with industry leading service and support 

Explore how Waters service and support ensures your LC-UV/MS and LC-MALS are ready to deliver maximum performance and reliability when characterizing and testing GLP-1 RA pharmaceuticals, while Waters compliance services help you meet your GxP compliance needs.

  • 合规性

Make science more accessible with Waters Capital

Make science more accessible with Waters Capital

Maximize your lab resources and minimize risk with payment options from Waters Capital, which includes innovative solutions to upgrade aging instruments, customized support, and flexible options to bundle your complete laboratory solution in one easy monthly payment – everything you need to advance your science.

  • Characterization
  • Quality control and Compliance

The data speaks for itself

The data speaks for itself

Identify impurities of GLP-1 RAs with LC-UV/MS. Example analysis of Exenatide shown with high purity and MS spectra of the main species peak.

UV chromatograms of liraglutide drug substance and generic drug product showing the native hexamer and aggregate species. The molar mass measured by MALS is overlaid on each peak.

Developing a scalable separation method to obtain a high purity sample of GLP-1 RAs

Developing a scalable separation method to obtain a high purity sample of GLP-1 RAs.

Mitigation of hydrophobic NSB to collection vessels using QuanRecovery with MaxPeak HPS 96-well Sample Collection plate, demonstrating improved MS peak response vs standard polypropylene plates for semaglutide.

Mitigation of hydrophobic NSB to collection vessels using QuanRecovery with MaxPeak HPS 96-well Sample Collection plate, demonstrating improved MS peak response vs standard polypropylene plates for semaglutide.


Resources


  • 再版文章

Analysis and Characterization of GLP-1 Peptides

Analysis and Characterization of GLP-1 Peptides
  • 應用手冊

Analytical Tools and Methodologies to Address the Challenges in the Development and Production of GLP-1 Receptor Agonists

Analytical Tools and Methodologies to Address the Challenges in the Development and Production of GLP-1 Receptor Agonists
  • 產品型錄

Waters Purification Product Guide

Waters Purification Product Guide
  • 產品型錄

Synthetic Peptide Purification Solutions

Synthetic Peptide Purification Solutions
  • 資訊圖表

Understanding Biotherapeutic Peptides and GLP-1 Receptor Agonists

Understanding Biotherapeutic Peptides and GLP-1 Receptor Agonists
  • Ordering Guide

Comprehensive Guide to Hydrolysis and Analysis of Amino Acids

Comprehensive Guide to Hydrolysis and Analysis of Amino Acids
  • 網路研討會點播

Method Development Considerations for the Manufacturing of GLP-1 Analogs with Reversed-Phase (RP) LC-UV/MS Technologies

Method Development Considerations for the Manufacturing of GLP-1 Analogs with Reversed-Phase (RP) LC-UV/MS Technologies
  • 網路研討會點播

Waters 2025 LC Symposium - Day 2 - GLP-1 Analog Development: Purification, Characterization, Release Testing

Waters 2025 LC Symposium - Day 2 - GLP-1 Analog Development: Purification, Characterization, Release Testing
  • 網路研討會點播

Development of Scalable Purification for Synthetic Peptides (GLP-1's) with Neopharm Boston

Development of Scalable Purification for Synthetic Peptides (GLP-1's) with Neopharm Boston
  • 網路研討會點播

Advancing GLP-1 Analog Drug Development Using a Variety of Light Scattering Techniques​

Advancing GLP-1 Analog Drug Development Using a Variety of Light Scattering Techniques​
  • 貼文

Characterizing Quality Attributes of GLP-1 Analogs by Light Scattering

Characterizing Quality Attributes of GLP-1 Analogs by Light Scattering
  • 貼文

Development of Separation Methods for GLP-1 Synthetic Peptides Utilizing a Systematic Protocol and MaxPeak High Performance Surface Technology

Development of Separation Methods for GLP-1 Synthetic Peptides Utilizing a Systematic Protocol and MaxPeak High Performance Surface Technology
  • 貼文

Comprehensive Workflow for Quantitative Bioanalysis of Large Peptides and Proteins: A Case Study of the GLP-1 Receptor Agonist, Semaglutide, in Plasma

Comprehensive Workflow for Quantitative Bioanalysis of Large Peptides and Proteins: A Case Study of the GLP-1 Receptor Agonist, Semaglutide, in Plasma
  • 貼文

Development of Improved Chromatographic Methods for the Separation of Synthetic Peptides Medications and Associated Impurities

Development of Improved Chromatographic Methods for the Separation of Synthetic Peptides Medications and Associated Impurities
  • 貼文

Principles and Practice Using SEC for Reliable Biotherapeutic Peptide Analysis

Principles and Practice Using SEC for Reliable Biotherapeutic Peptide Analysis
  • 白皮書

Advancing QC Efficiency with SEC-MALS System and Empower Software

Advancing QC Efficiency with SEC-MALS System and Empower Software

Related

沃特世为合成肽(例如类胰高血糖素肽1 (GLP-1))的实验室规模纯化、表征和监测提供出色的解决方案,确保药物开发顺利进行且符合质量标准。

沃特世针对多属性方法(MAM)表征和常规监测分析提供全面的LC-MS和MS工作流程,可以加深您对生物治疗药物和疫苗产品生物分析的理解。

利用沃特世样品前处理产品获得可重现、高回收率且不存在干扰的样品。成熟可靠的样品前处理工具,适用于LC-MS和GC-MS分析。

使用沃特世质量控制标准品(即用型标准品和混合物组合)进行基准测试,确保LC和LC-MS色谱柱和系统性能达到理想状态。

Learn more about GLP-1 Receptor Agonists Solutions.

Learn more about GLP-1 Receptor Agonists Solutions.

GLP-1 RA Molecule
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