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Three Reasons for Biopharmaceutical Labs to Add Mass Detection to Routine Analyses
As regulators focus in on the critical quality attributes of biotherapeutics, what can biopharmaceutical labs in late development or QC do to increase confidence in their bioseparations – other than to run more assays?
ACQUITY Arc System: Transferring Validated HPLC Methods within USP Guidelines
The thought of transferring established high performance liquid chromatography (HPLC) methods onto a another vendor’s LC, or a new platform like UHPLC/UPLC, may cause a bit of anxiety for those that may be unaware of how easy it can be. The reason that the topic of analytical method transfer induces so much angst is that...
Can Sports Cars Increase Testosterone?
According to published reports by Hiscox UK in 2008, just listening to the sound of a sports car increased salivary testosterone levels in male and female participants. Another study, by Gad Saad et al, measured a testosterone increase in men who were given the opportunity to drive a $150,000 Porsche 911 Carrera Cabriolet for an...
When Consumables Kits are Greater Than the Sum of their Parts
ProteinWorks and GlycoWorks kits address more than sample prep challenges One of the most challenging parts of an LC-MS workflow happens before analytical chemists even turn to their instrument: Sample preparation. Get it right, and the analytical run performs as expected. Get it wrong, and the assay has any number of problems, from poor sensitivity...
What do an ancient Chinese Ruler and Waters’ Mass Spectrometry Research Team have in common?
Tea is very important to them! If Waters Wilmslow ran out of tea it is likely the MS Research Team would struggle to function. The ancient Chinese Ruler, Emperor Jing Di, took tea to the grave with him for a cuppa in the afterlife. Many treasures were found in his tomb including; food, weapons, ceramic animals,...
Effective Use of the ACQUITY QDa Mass Detector with Your LC: A Q and A with Dr. Tom Wheat
I recently presented a webinar describing some techniques and tools used for effectively using the QDa Mass Detector with liquid chromatography systems. Several attendees submitted questions that may be of general interest to a broader audience. It is better, as you said, to use negative mode for acidic compounds (like carboxylic acid), but these...
5 Insights: Protein Quantification Using the Surrogate Peptide Method
What can you get all the top Pharma and CRO's scientists to agree on? That the biopharma industry is growing and quantifying biotherapeutics for bioanalysis is difficult - but you have options.
Developing Separation Methods for Natural Products: Questions and Answers from a Webinar with Dr. Tom Wheat
The development of chromatographic methods for natural products is challenging due to the complexity of the sample matrix and analyte chemistry. However, by understanding the fundamental parameters of your chromatography and strategies for efficient detection, there are many ways to overcome these difficulties. I recently presented a webinar describing some techniques and tools used for...