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Mission Improbable: Rapid Total Sugar Reporting for Beer by Mass Detection
Lion, one of the largest food and beverage companies in Australia and New Zealand, wanted to monitor fermentation profiles to completion as the company introduced voluntary nutritional panels across its beer portfolio. See what they gained by changing from electrochemical to mass detection.
A CRO Leads the Way for Biotherapeutics Amid its Own ‘Field of Dreams’
“If You Build it, He Will Come” Urged on by a voice no one else could hear, Ray Kinsella, played by Kevin Costner in the movie Field of Dreams, cleared a few acres of corn to build a baseball field. Shortly after, magical things began to happen. When you first set eyes on the headquarters...
Analytical Tools for Developing Biosimilars: Part 3, Glycosylation, Aggregation, and Charge Variants
In biotherapeutics, the state of glycosylation has a direct and pronounced effect of the structure, stability, serum half-life, immunogeneicity and bioactivity of the molecule, and constitutes a critical quality attribute (CQA). In our study, characterizing and comparing the glycosylation profile of infliximab began by examining the glycosylation profiles from intact and reduced subunit mass data.
Analytical Tools for Developing Biosimilars: Part 2, Peptide Analysis
Advancements in High-Resolution Analytics for Characterization of Innovator and Biosimilar Therapeutics Part 2: Peptide Analysis of Infliximab
How Analytical Technologies Support the Development of Biosimilar Drugs
Advancements in High-Resolution Analytics for the Characterization of Innovator and Biosimilar Therapeutics As the pharmaceutical industry continues to evolve its focus from small-molecule drugs to balanced product portfolios that include protein therapeutics, analytical chemists are increasingly challenged to produce routine and automated characterization workflows that move innovator and biosimilar biopharmaceutical products forward through development and...
Advancing Omics Research and Reducing Bias with New MS Technology for Data-Independent Acquisition Experiments
Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding of biological systems in terms of drug development and treatment. Understanding the context of analytical results is driving current research,...
Phenome Network: A Harmonized Research Consortium for Innovative Global Health
The world is facing an unprecedented convergence of environmental and lifestyle factors that dramatically increase our risk of chronic disease. Global warming, antimicrobial resistance, aging populations, and the prevalence of lifestyle-related illnesses are systematically affecting populations around the world and posing some of the greatest scientific and public health threats seen in modern times. These...
Detecting Bisphenol A (BPA) in Infant Products with Mass Spec
Developing a Rapid, Routine Method for Extraction and Quantification in Complex Infant Products with UPLC/MS-MS Bisphenol A (BPA) is an additive that is primarily used in the production of polycarbonate plastics and epoxy resins. These synthetic materials are widely used in packaging to protect the safety and integrity of foods and beverages. Polycarbonates are used...