Small Molecule Bioanalysis

Small Molecule Bioanalysis

Streamline drug development with reliable, sensitive, and efficient bioanalysis assays from discovery to late-stage clinical trials. Waters advanced UPLC-MS/MS solutions, with high-performance chromatography and sample preparation chemistries and consumables, together deliver dependable performance for bioanalysis of traditional small molecule drug candidates. Trust Waters to ensure consistent, high-quality quantitative data for faster, more accurate decision-making that drives drug development forward.

Streamline drug development with reliable, sensitive, and efficient bioanalysis assays from discovery to late-stage clinical trials. Waters advanced UPLC-MS/MS solutions, with high-performance chromatography and sample preparation chemistries and consumables, together deliver dependable performance for bioanalysis of traditional small molecule drug candidates. Trust Waters to ensure consistent, high-quality quantitative data for faster, more accurate decision-making that drives drug development forward.
Reliably and accurately quantify drug candidates in biological matrices, from transitional small molecules to novel classes (e.g., PROTACs), with Waters trusted LC-MS/MS solutions for quantitative bioanalysis.
Reliably and accurately quantify drug candidates in biological matrices, from transitional small molecules to novel classes (e.g., PROTACs), with Waters trusted LC-MS/MS solutions for quantitative bioanalysis.

Overview

Waters trusted sample preparation solutions, resolving chromatography columns & systems, and high-performance tandem quadrupole mass spectrometers and software facilitate the development and implementation of high-quality quantitative bioanalysis assays.

Whether you need flexibility and throughput to support discovery bioanalysis or the highest sensitivity and reproducibility to support preclinical to clinical trials, Waters UPLC-MS/MS solutions are purposely designed to address your critical quantitively bioanalysis challenges.

Molecule background

Applications

Accurate measurement of drug and metabolite concentrations in biofluids is critical for determining a candidate’s pharmacokinetic profile in DMPK. Discover how Waters trusted sample preparation, chromatography technologies, and advanced UPLC-MS/MS systems overcome sensitivity challenges, even for low-dose, low-exposure compounds.

Accurate measurement of drug and metabolite concentrations in biofluids is critical for determining a candidate’s pharmacokinetic profile in DMPK. Discover how Waters trusted sample preparation, chromatography technologies, and advanced UPLC-MS/MS systems overcome sensitivity challenges, even for low-dose, low-exposure compounds.

Application Notes

Application Notes
Assess drug safety and determine the biotransformation of a drug compound and with quantitative bioanalysis solutions from Waters.

Solutions

Waters UPLC-MS/MS systems deliver absolute performance in separation and sensitivity for bioanalysis of small molecule drug candidates in biological fluids.

Waters UPLC-MS/MS systems deliver absolute performance in separation and sensitivity for bioanalysis of small molecule drug candidates in biological fluids.

Absolute performance for lowest levels of quantification

Absolute performance for lowest levels of quantification
Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer

Expand your analytical capabilities with the compact Xevo TQ Absolute tandem quadrupole mass spectrometer, bringing superior performance, absolute sensitivity, and sustainable technology for robust quantification of drugs and metabolites.

  • 高靈敏度生物分析

High performance quantitation in a compact form

High performance quantitation in a compact form
Xevo TQ–S micro Tandem Mass Spectrometer

Optimize performance per square inch in routine quantitation, injection after injection, with the Xevo TQ-S micro, for exceptional analytical flexibility and sensitivity even with the most complex sample matrices.

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Dependable high performance chromatography

Dependable high performance chromatography
ACQUITY Premier UPLC System

Optimize chromatographic resolution and speed while eliminating concerns of non-specific binding for sensitive analytes with the Waters ACQUITY Premier UPLC System and enhance overall quantitative performance in bioanalysis assays.

  • 高靈敏度生物分析

Streamlined confidence for GLP and non-GLP in vivo bioanalysis.

Streamlined confidence for GLP and non-GLP in vivo bioanalysis.

Streamline quantitative data acquisition and processing

Streamline quantitative data acquisition and processing
waters_connect for Quantitation

Accelerate workflows, ensure confidence in compliance and dominate your data with our scalable, compliance enabled waters_connect for Quantitation software available on our core Xevo tandem quadrupole family of mass spectrometers.

  • 高靈敏度生物分析

Quality consumables to support your bioanalysis success.

Quality consumables to support your bioanalysis success.

Speed. Sensitivity. Resolution and confidence. You can have it all.

Speed. Sensitivity. Resolution and confidence. You can have it all.
ACQUITY Premier Columns

Develop the most sensitive, reliable, and high-performance bioanalysis methods and reduce risks associated with unpredictable chromatography with ACQUITY Premier Columns with MaxPeak High Performance Surfaces (HPS) Technology.

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Faster, simpler, more effective sample preparation in bioanalysis

Faster, simpler, more effective sample preparation in bioanalysis
Oasis Solid-Phase Extraction (SPE) Products

Meet a wide variety of sample preparation needs, from simple and fast sample matrix clean-up to more complex sample preparation challenges with Oasis SPE products that deliver unmatched purity, consistency, and quality for sample analysis.

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A simpler way to cleaner samples

A simpler way to cleaner samples
Ostro Pass-Through Sample Preparation Products

Eliminate time-consuming, complicated sample preparation with Ostro Pass-Through Sample Preparation Products, providing a simple solution for phospholipid and protein removal with minimal method optimization.

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Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Your success is just a click away

Your success is just a click away
Waters Global Services

Optimize your laboratory's productivity and success with Waters Global Services. Maintain peak system performance, minimize downtime, address application challenges, and support stringent compliance requirements.

  • 高靈敏度生物分析

Make science more accessible with Waters Capital

Make science more accessible with Waters Capital
Payment Solutions

Maximize your lab resources and minimize risk with payment options from Waters Capital, which includes innovative solutions to upgrade aging instruments, customized support, and flexible options to bundle your complete laboratory solution in one easy monthly payment – everything you need to advance your science.

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The data speaks for itself

The data speaks for itself
Gefitinib – LLOQ comparison between ACQUITY Premier System with MaxPeak HPS Column vs. standard ACQUITY LC system with standard column
Gefitinib – LLOQ comparison between ACQUITY Premier System with MaxPeak HPS Column vs. standard ACQUITY LC system with standard column.
LC-MS chromatograms precursors for Phospholipid m/z = 184 for sample extracted with the Ostro Plates show significantly less signal (red trace) than the sample extracted using the organic solvent method (green trace)
LC-MS chromatograms precursors for Phospholipid m/z=184 for sample extracted with the Ostro Plates show significantly less signal (red trace) than the sample extracted using the organic solvent method (green trace).
Simultaneous RADAR and MRM acquisition in rat urine sample following oral administration of methapyrilene at 150 mg/Kg. Peak at tR=1.7 min from the MRM transition methapyrilene 262.2→119.2 in positive ion ESI mode
Simultaneous RADAR and MRM acquisition in rat urine sample following oral administration of methapyrilene at 150 mg/Kg. Peak at tR=1.7 min from the MRM transition methapyrilene 262.2→119.2 in positive ion ESI mode.
Xevo TQ Absolute limit of detection of Midazolam and Imipramine in rat plasma was determined to be 0.2 pg/mL for both analytes, with the lowest level calibrator and all four QC samples at that level being detectable in all cases.
Xevo TQ Absolute limit of detection of Midazolam and Imipramine in rat plasma was determined to be 0.2 pg/mL for both analytes, with the lowest level calibrator and all four QC samples at that level being detectable in all cases.

Webinars and Resources

  • 產品型錄

Flyer: Xevo TQ Absolute Sustainability and Cost Savings in the Lab

Flyer: Xevo TQ Absolute Sustainability and Cost Savings in the Lab
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  • 應用手冊

Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape

Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape
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定量生物分析
Waters提供多功能定量生物分析解決方案，能靈活支援候選藥物在整個藥物開發流程中的研究進展。

新模態藥物的DMPK研究
Waters的UPLC-MS/MS生物分析解決方案功能豐富、效能優異，相當適合用於為DMPK檢測開發穩定、靈敏的生物分析方法。歡迎瀏覽我們的DMPK解決方案，尋找有助於針對新模態藥物進行生物分析的工具和技術。

體外ADME分析
Waters針對體外ADME分析的LC-MS/MS技術與耗材，可助您開發可靠穩定的ADME分析方法，同時降低敏感化合物可能發生的任何非特異性結合的風險。

大分子生物分析
Waters UPLC-MS/MS大分子生物分析解決方案可用於執行胜肽、蛋白質和寡核苷酸分析，克服藥物開發過程中在定量方面的挑戰。

Learn more about Small Molecule Bioanalysis Solutions.

Learn more about Small Molecule Bioanalysis Solutions.
Reliably and accurately quantify drug candidates in biological matrices, from transitional small molecules to novel classes (e.g., PROTACs), with Waters trusted LC-MS/MS solutions for quantitative bioanalysis.
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