Libreria


Descrizione
TRASFERIMENTO DELL’ANALISI USP PER LA SIMVASTATINA AL SISTEMA UPLC
Numero di Library: 720001901EN | Format: PDF | Formato del file: 514.32 kB | Anno: 2007 | Contenuto: Note applicative

TRASFERIMENTO DELL’ANALISI USP PER LA SIMVASTATINA AL SISTEMA UPLC

Comprehending COVID-19: Analytical Science in the Context of COVID-19
Numero di Library: APNT135075423 | Format: PDF | Formato del file: 144.26 kB | Anno: 2020 | Contenuto: Note applicative

Here, we briefly discuss the role of LC and/or LC-MS for each of these applications along with a sampling of select application notes. Our hope is that by providing a COVID-19 resource hub, organizations can quickly access relevant knowledge useful for th...

Size Exclusion Chromatography Method Transfer of a Monoclonal Antibody Across UHPLC Systems
Numero di Library: APNT135076654 | Format: PDF | Formato del file: 357.91 kB | Anno: 2020 | Contenuto: Note applicative

This application brief demonstrates a size-exclusion chromatography method transfer for monoclonal antibody analysis from an Agilent 1260 Infinity Bio-Inert LC System to an ACQUITY Arc Bio Aystem with ACQUITY 30cm Single Zone Column Manager (CM-30S).

Quantitative Analysis of Natural and Synthetic Estrogens in Surface and Final Effluent Waters at Low...
Numero di Library: APNT134940437 | Format: PDF | Formato del file: 1032.16 kB | Anno: 2020 | Contenuto: Note applicative

This application note summarizes a method for the analysis of estrone, 17α-ethinylestradiol and 17β-estradiol in surface and final effluent waters.

Enabling Routine and Reproducible Intact Mass Analysis When Data Integrity Matters
Numero di Library: APNT135007110 | Format: PDF | Formato del file: 1605.42 kB | Anno: 2020 | Contenuto: Note applicative

This study describes how the BioAccord™ System, a compact high-performance LC-MS platform, streamlines data acquisition, processing, and reporting for intact mass analysis.

QuanOptimize: A Software Tool that Enables Rapid, Consistent, and Accurate MRM Method Development fo...
Numero di Library: APNT135076524 | Format: PDF | Formato del file: 780.33 kB | Anno: 2020 | Contenuto: Note applicative

In this application brief, we discuss the use of QuanOptimize to develop methods for a set of 18 small molecule compounds using generic tune page and LC methods.

Intact Mass Confirmation Analysis on the BioAccord LC-MS System for a Variety of Extensively Modifie...
Numero di Library: APNT135076526 | Format: PDF | Formato del file: 706.88 kB | Anno: 2020 | Contenuto: Note applicative

This application note demonstrates an automated compliance-ready LC-MS workflow for mass confirmation of unmodified and extensively modified oligonucleotides.

Increased Resolving Power for Acidic Glycans with an MS-Compatible Anion Exchange Reversed Phase Sep...
Numero di Library: APNT135076530 | Format: PDF | Formato del file: 584.81 kB | Anno: 2020 | Contenuto: Note applicative

A novel mixed-mode, anion-exchange RPLC stationary phase has been used to afford a class separation of different charge states and additional resolution of acidic glycans.

Amino Acid Analysis using Andrew+ Automated Preparation
Numero di Library: APNT135076533 | Format: PDF | Formato del file: 1590.52 kB | Anno: 2020 | Contenuto: Note applicative

The objective of this application note is to demonstrate the equivalency and robustness of manual preparations of AccQ●Tag labelled amino acids to those prepared using the Andrew+ liquid handling robot with amino acid standard kits.

Comprehending COVID-19: Rapid and Sensitive Characterization of N-Glycans from SARS-CoV-2 Spike Prot...
Numero di Library: APNT135071689 | Format: PDF | Formato del file: 430.2 kB | Anno: 2020 | Contenuto: Note applicative

This work utilizes the GlycoWorks RapiFluor-MS N-Glycan Kit to easily and rapidly detect SARS-CoV-2 spike protein N-Glycans.

Screening Workflow Using Ion Mobility-Mass Spectrometry for The Analysis of Extractables and Leachab...
Numero di Library: APNT135076492 | Format: PDF | Formato del file: 1465.95 kB | Anno: 2020 | Contenuto: Note applicative

This application note outlines how using the UNIFI Scientific Information System within an E&L workflow allows for the incorporation of both targeted and non-targeted screening within one application, as well as how to create a scientific library, perform...

Analysis of Cysteine-Conjugated Antibody Drug Conjugates (ADCs) Using a Native SEC LC-MS Workflow on...
Numero di Library: APNT135075751 | Format: PDF | Formato del file: 527.89 kB | Anno: 2020 | Contenuto: Note applicative

In this application brief, we have demonstrated an analytical scale native SEC LC-MS analysis workflow that can be applied across LC-MS systems for the analysis of cysteine conjugated ADCs. SEC-MS based workflows offer the efficiency benefits of automated...

Targeted UPLC-MS/MS Analysis of Oxylipins
Numero di Library: APNT135075761 | Format: PDF | Formato del file: 656.21 kB | Anno: 2020 | Contenuto: Note applicative

In this application note we present a targeted UPLC-MS/MS methodology for the semi-quantitative profiling of bioactive oxylipins (oxidized fatty acids) in plasma/serum and cell culture media.

Improved Injection Precision of USP Methods with an Arc HPLC System
Numero di Library: APNT135075663 | Format: PDF | Formato del file: 424.93 kB | Anno: 2020 | Contenuto: Note applicative

In this application note, the injection precision for several regulated methods will be assessed using multiple HPLC systems.

Application of a Mass Confirmation Workflow for Biotherapeutics Screening
Numero di Library: APNT135075434 | Format: PDF | Formato del file: 1125.28 kB | Anno: 2020 | Contenuto: Note applicative

In this study, we report the development of a high throughput intact mass confirmation workflow using the BioAccord LC-MS System operated under the control of waters_connect informatics.

Improved Chromatographic Performance with a PREMIER Peptide C18 Column Versus a Titanium-Lined C18 C...
Numero di Library: APNT135075359 | Format: PDF | Formato del file: 356.35 kB | Anno: 2020 | Contenuto: Note applicative

In this application brief, we compare a commercially available column, lined with titanium and constructed with titanium frits, against an ACQUITY PREMIER Peptide C18 Column, which features MaxPeak High Performance Surface (HPS) Technology.

The Analysis of Tetracycline and Sulfonamide Antibiotics in Shrimp Tissue using Liquid Chromatograph...
Numero di Library: APNT135047367 | Format: PDF | Formato del file: 406.37 kB | Anno: 2020 | Contenuto: Note applicative

This application note describes the results of a successful validation of the analysis of shrimp tissue for tetracyclines, sulfonamides, trimethoprim, ormetoprim, and dapsone using the Waters™ ACQUITY UPLC I-Class PLUS System coupled to the Xevo TQ-S micr...

Ensuring Data Quality and Column Performance in Bioanalytical Workflows Using Routine Injections of ...
Numero di Library: APNT135075369 | Format: PDF | Formato del file: 314.8 kB | Anno: 2020 | Contenuto: Note applicative

In this work, a Quality Control Reference Material (QCRM) is used to monitor column performance throughout testing of protein precipitated plasma.

Increasing Chromatographic Performance of Acidic Peptides in RPLC-MS-based Assays with ACQUITY PREMI...
Numero di Library: APNT135075223 | Format: PDF | Formato del file: 928.05 kB | Anno: 2020 | Contenuto: Note applicative

In this study, the performance gain of ACQUITY PREMIER Columns with MaxPeak HPS Technology is demonstrated with increased recovery, reproducibility, and robustness of RPLC-MS-based peptide mapping assays using the Waters NIST mAb tryptic digest standard.

Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology
Numero di Library: APNT135075015 | Format: PDF | Formato del file: 1270.94 kB | Anno: 2020 | Contenuto: Note applicative

This application note describes a single, analytical method for the extraction and quantification of various oligonucleotides (15-35T). Using reversed-phase (RP) and mixed-mode ion exchange µElution solid phase extraction (SPE) sample preparation provided...

Comprehending COVID-19: Using the Atlantis PREMIER BEH C18 AX Mixed-Mode Column for the Analysis of ...
Numero di Library: APNT135075018 | Format: PDF | Formato del file: 337.24 kB | Anno: 2020 | Contenuto: Note applicative

This application note demonstrates that sharper peaks can be achieved for umifenovir through the use of a mixed-mode stationary phase versus a more conventional reversed-phase material.

Comprehending COVID-19: Maximizing LC-MS Detection Dynamic Range for Multiple Reaction Monitoring Ba...
Numero di Library: APNT135075039 | Format: PDF | Formato del file: 428.65 kB | Anno: 2020 | Contenuto: Note applicative

In this application brief, the combination of selected chemistries and consumables, using the ACQUITY UPLC I-Class PLUS System and Xevo TQ-XS Tandem Quadrupole Mass Spectrometer, are demonstrated for the detection and quantification of SARS-CoV-2 proteins...

Comprehending COVID-19: Multiple Reaction Monitoring Transition Selection and Optimization Strategie...
Numero di Library: APNT135074918 | Format: PDF | Formato del file: 698.31 kB | Anno: 2020 | Contenuto: Note applicative

The work presented here demonstrates application of the MassLynx Skyline Interface for automated peptide Multiple Reaction Monitoring selection and optimization with a Xevo TQ-XS Tandem Quadrupole Mass Spectrometer.

A Complete Workflow for the Determination of Drugs that Conforms to the Society of Hair Testing (SoH...
Numero di Library: APNT135074842 | Format: PDF | Formato del file: 538.85 kB | Anno: 2020 | Contenuto: Note applicative

This application brief details a workflow that can be used to quantify a panel of drugs at cut-off concentrations recommended by both the SoHT and EWDTS from a single hair specimen using a commercially available extraction buffer and OASIS PRiME MCX 96-We...

Utilization of MaxPeak High Performance Surfaces for Improved Separation and Recovery of Analytes As...
Numero di Library: APNT135041807 | Format: PDF | Formato del file: 1355.55 kB | Anno: 2020 | Contenuto: Note applicative

A reproducible LC-MS method is described for the analysis of the TCA cycle analytes as well as other related compounds without the need for sample derivatization or ion-pairing reagents.