High Sensitivity Bioanalysis Using the Xevo TQ-XS Tandem Quadrupole Mass Spectrometer

Bibliotheks-Nummer:
APNT135083036
Artikelnummer:
720007208EN
Autor(en):
Billy J. Molloy, Robert S. Plumb
Quelle:
Waters
Inhalt:
Applikationsmitteilungen
Untergruppe:
Applikationsmitteilungen
Verwandte Produkte:
 
 
 
 
 

A reproducible high sensitivity UPLC-MS/MS bioanalytical methodology is demonstrated using the Xevo TQ-XS Tandem Quadrupole Mass Spectrometer. A simple protein precipitation sample preparation was used for the detection of Midazolam and Imipramine down to 250 ag on column (0.2 pg/mL). This limit of detection was also shown to be reproducible across three separate UPLC-MS/MS systems. 


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