Tof-MRM for the Confirmation of Fentanyl Analogues for Forensic Toxicology

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Michelle Wood and Tom Rosano
Waters, Albany Medical Center
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The objective of this current analytical work was to evaluate the performance of Tof-MRM – a targeted mode of acquisition, which is also available on the same HRMS platform and to develop a confirmatory method for the fentanyl class. A secondary aim was to utilize a previously reported novel technique i.e., Threshold Accurate Calibration (TAC), for matrix normalization without the requirement for deuterated internal standards.

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