Protein Biomarker Discovery

Exploit and visualize the benefits of coupling high peak capacity ACQUITY UPLC M-Class or ACQUITY UPLC separations with SYNAPT G2-Si HDMS or Xevo G2-XS and powerful software for the bottom-up analysis of complex mixtures in proteomics, metabolomics, and lipidomics.

Sample Preparation

• RapiGest enzymatic digest promoter
• MassPREP quantitative standards

Chromatography

• ACQUITY UPLC M-Class for 1D reversed-phase
• ACQUITY UPLC M-Class for 2D RP/RP for low pH/high pH separations

Mass Spectrometry

• SYNAPT G2-Si HDMS to perform LC/MS (DDA, DIA, ETD) and MALDI on a single platform
• Xevo G2-XS QTof for a compact benchtop system with attomole sensitivity

Bioinformatics

• Progenesis QI for Proteomics
  • Sample comparisons across multiple groups, analytical and biological replicates
  • Peptide/protein ID from DDA and/or DIA
  • Hi”n” quantification
  • Flexible statistical tools including ANOVA, PCA, hierarchical clustering, power analysis
  • Flexible report generator for information sharing Quality Metrics, a rapid visual check of sample measurements and analytical quality

System Verification

• Waters Proteomics System Verification Kit