Discovery proteomics aims to understand the important functional roles of these complex macromolecules. Accurate identification of the proteins differentially expressed in disease states can be potentially translated to functional biomarkers given appropriate validation studies. Feeding this translational pipeline with high quality results is a challenging analytical task. Due to the functional role of Proteins in biological processes, proteomics also plays an important component of systems biology approaches. Multi-Omic analysis helps validate findings and fill gaps in understanding of metabolic and signaling processes.
Read how our customers have found success with Waters Proteomics solutions here.
High-resolution Mass Spectrometry is the gold standard analytical tool for measuring the complexity of the Proteome. Waters pioneered the use of Data Independent Acquisitions (DIA) expressly to improve the quantitative analysis of “bottom-up” non-labeled proteomics methods whilst generating peptide fragment spectra for all detectible species.
Dig deeper into the proteome by coupling Waters DIA methods with high peak capacity ACQUITY UPLC M-Class or ACQUITY UPLC separations, SYNAPT XS or Xevo G2-XS, and Progenesis software.
Read peer reviewed articles in the field of proteomics.