Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!
SKU: 186008317 RapiFluor-MS High Mannose Test Standard
RapiFluor-MS High Mannose Test Standard | 186008317
The RapiFluor-MS High Mannose Standard is intended for use as a proficiency or system suitability test standard. This standard contains approximately 1000 pmoles of purified, RapiFluor-MS labeled N-glycans from bovine ribonuclease B and can be used on its own or it can be spiked into an N-glycan pool for the detection of high mannose structures: M5, M6, M7, M8, and M9.
The RapiFluor-MSTM High Mannose Test Standard is a proficiency or system suitability test standard. In the production of biotherapeutics, high mannose structures are often checked for low half-life and the health of cell culture (suggests incomplete glycosylation process and implying manufacturing difficulties).
This lab equipment contains around 1000 pmoles of pure, RapiFluor-MS tagged N-glycans from bovine ribonuclease B that can be used alone or spiked into an N-glycan pool to demonstrate system appropriateness or competency for the detection of high mannose N-glycan structures. M5, M6, M7, M8, and M9 mannose structures are included in this standard. It produces a very simple mixture when used on its own, but it can also be utilized and diluted as a series of spiked samples into a complicated matrix with variable concentrations. This is especially useful for monoclonal antibody samples that frequently contain these high mannose species.
As the world’s leading authority on scientific lab equipment manufacturing, Waters has invested in extensive research and continues to produce a wide range of standards and reagents. You can explore the complete range using our online catalog available through our website, which also allows you to shop for lab equipment.
Waters recommends that you also explore and invest in the GlycoWorks RapiFluor-MS N-Glycan Refill Kit-24 sample. The lab equipment lowers complex, time-consuming sample preparation to just three simple processes in as little as 30 minutes. The chemical properties of RapiFluor-MS (RFMS) enable increased fluorescence quantification and superior mass spectral response. From characterization to routine monitoring, you can now use a single label that delivers significant information. Glycan analysis has recently been a whole lot easier and a lot more sensitive. The GlycoWorks Deglycosylation Module (186008841) and the GlycoWorks Labeling Module (186008091) are provided combined in this refill kit to augment either the 176003712 or 176003713 kits or as supplementary reagents for the 96 sample kits. It comes with everything you need to process 24 samples in a 3x8 format.
How Should The RapiFluor-MS High Mannose Test Standard Be Stored?
For long-term storage until solubilization, keep the standard frozen in its original packing at -20 °C when it arrives. The sample can be aliquoted and frozen at -80 °C for up to 3 months or stored at 4–10 °C for no more than a week after being solubilized, avoiding any freezing or thawing that could cause degradation.
