XSelect Columns

XSelect Columns

Achieve unmatched reproducibility with a wide range of selectivity

Achieve unmatched reproducibility with a wide range of selectivity

Quickly and easily develop robust methods compatible with all modern chromatographic detection modes and transfer them from lab to lab with the XSelect Column family.

Designed to help you achieve reproducible and highly selective chromatographic separations, the XSelect Column family features two base particles technologies, Charged Surface Hybrid (CSH) and High Strength Silica (HSS). With XSelect Columns, method development scientists like you can achieve a wide range of selectivities across all application areas, without compromising performance.


Unwanted interactions between analytes and metal ions?

XSelect Premier Columns with MaxPeak HPS technology mitigate interactions with stainless-steel column hardware.

Specifications

Overview

  • Designed for selectivity and stability at low pH
  • Superior peak shape for basic compounds
  • Highest analyte mass loading available
  • Excellent batch-to-batch reproducibility
  • Ideal for rapid method development
  • CSH Column chemistries: C18, Fluoro-Phenyl (PFP), and Phenyl-Hexyl, available in 2.5 XP, 3.5, 5 μm analytical and 10 μm OBD preparative sizes
  • HSS Column chemistries: HSS C18, C18 SB, and T3, available in 2.5 XP, 3.5, and 5 μm particle sizes
  • Prolonged column lifetimes with optional VanGuard Cartridges specifically designed using XSelect stationary phases

Recommended Use: For improving selectivity, peak shape, and retentivity in methods development.


XSelect CSH Column Characteristics

XSelect CSH Column Characteristics

XSelect CSH-C18 Columns
  • Alternative selectivity to existing C18 columns
  • Low anion exchange
  • High efficiency
  • Excellent pH stability
  • Ideal for improved peak shape for bases with low pH mobile phase
  • General purpose hybrid column
XSelect CSH Phenyl-Hexyl Columns
  • Alternative selectivity for aromatic compounds
  • Medium anion exchange
  • High efficiency
  • Excellent pH stability
  • Ideal for improved peak shape for bases with low pH mobile phase
  • General purpose hybrid column
XSelect CSH Fluoro-Phenyl (PFP) Columns
  • Alternative selectivity for acids and bases
  • High anion exchange
  • High efficiency
  • Excellent pH stability
  • Ideal for improved peak shape for bases with low pH mobile phase
  • General purpose hybrid column

XSelect HSS Column Characteristics

XSelect HSS Column Characteristics

XSelect HSS-C18 Columns
  • High efficiency for acids, bases, neutrals
  • Excellent low pH stability
  • General purpose silica columns
  • High retention
XSelect HSS T3 Columns
  • Excellent retention for polar analytes
  • 100% water wettable
  • High retention
  • High efficiency
  • Excellent low pH stability
XSelect HSS C18 SB Columns
  • Alternative selectivity for bases
  • Increased cation exchange at mid pH
  • General purpose silica columns
  • High retention
  • High efficiency
  • Excellent low pH stability
XSelect HSS PFP Columns
  • Alternative selectivity for polar bases
  • Alternative selectivity for aromatic compounds
  • General purpose silica columns
  • High retention
  • High efficiency
  • Excellent low pH stability
XSelect HSS CN Columns
  • Stable and reproducible cyano chemistry
  • Alternative selectivity and increased retention for polar compounds
  • General purpose silica columns
  • High retention
  • High efficiency
  • Excellent low pH stability

Increase selectivity across compounds

Using selectivity and retentivity to influence chromatographic behavior is common in method development. With the choice of phases in the XSelect HPLC and UHPLC family, you can achieve selectivity and retention across a wide variety of compounds by using different base particles.

The XSelect HSS and CSH particles provide enhanced selectivity for acidic, alkaline and neutral compounds. The XSelect CSH Phenyl-Hexyl Column places more emphasis on reversed-phase interactions compared to secondary Lewis-base interaction. The XSelect HSS C18 SB Column was engineered to provide enhanced retention for basic polar compounds using low-pH mobile phases. When compared to a standard C18 phase, XSelect HSS T3 Columns provide increased retention for polar compounds.


Powerful tools for your method development

The scalability and versatility of XSelect CSH Columns enables you, the isolation and purification scientist, to use them as powerful method development tools. The hybrid materials used to create the CSH stationary phases are known industry-wide for being the most pressure-tolerant columns on the market. Rugged performance combined with Optimum Bed Density (OBD) packing technology produces columns that have exceptional column lifetimes under a wide range of operating conditions. With the columns’ scalable design, you can choose from larger to smaller and narrower preparative columns to reduce solvent consumption and fraction volumes.


Achieve flexibility in method development

Chromatographic laboratories need to quickly and easily develop robust methods that are compatible with all modern chromatographic detection modes and transferrable to laboratories and sites that operate different LC system platforms. With ACQUITY UPLC CSH and XSelect Columns, method development scientists in all application areas can achieve a wide range of selectivities without compromising performance across attributes, including superior peak shape for basic compounds, low column bleeds, excellent batch-to-batch reproducibility, and high efficiency.



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Related

Prolong analytical column lifetime while maintaining chromatographic performance with VanGuard Pre-columns and cartridges.

Discover XSelect Premier UHPLC Columns designed to improve peak shape and maximize selectivity while mitigating unwanted analyte/surface interactions.

Ensure peak LC and LC-MS column and system performance by benchmarking with Waters Quality Control Reference Materials, a portfolio of ready-to-use standards and mixes.

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