Discovery Lipidomics

Discovery Lipidomics

Waters discovery lipidomics solutions help your lab get the deepest coverage for diverse lipidomes with minimal loss and maximum peak capacity, identify lipids with high-resolution mass spectrometry and maintain the analytical flexibility for innovative lipid studies.

Waters discovery lipidomics solutions help your lab get the deepest coverage for diverse lipidomes with minimal loss and maximum peak capacity, identify lipids with high-resolution mass spectrometry and maintain the analytical flexibility for innovative lipid studies.
Achieve deepest coverage of diverse lipidomes, confidently identify lipids with ion mobility, and obtain analytical flexibility for advanced lipid studies with Waters discovery lipidomics solutions.
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Overview

Discovery lipidomics aims to measure a biological system’s complete set of lipids in an unbiased manner. The diversity of chemical composition and natural abundance levels challenge chromatographic and mass spectrometric performance. Waters discovery lipidomics solutions are developed to deliver comprehensive lipidome coverage that includes:

  • Deepest coverage for a diverse lipidome: ACQUITY Premier minimizes lipid loss while ion-mobility maximizes peak capacity, measuring more of the lipidome.
  • Confident lipid identification with ion mobility: High-resolution mass spectrometry combines with data independent acquisition, CCS measurements and library support.
  • Analytical flexibility to study lipids in new ways: Extending LC-MS/MS capability with unique ion mobility experiments and imaging applications with DESI XS.

Applications

Combining a high-performance LC, such as the ACQUITY Premier System with ion mobility – high resolution mass spectrometry, powers high peak capacity lipid separations for discovery lipidomics and delivers valuable Collision Cross-Section (CCS) measurements for all species. Learn how to take your lipidomics profiling further with these application notes.

Combining a high-performance LC, such as the ACQUITY Premier System with ion mobility – high resolution mass spectrometry, powers high peak capacity lipid separations for discovery lipidomics and delivers valuable Collision Cross-Section (CCS) measurements for all species. Learn how to take your lipidomics profiling further with these application notes.

Application Notes

Application Notes
Select Series Cyclic IMS Closeup

Add biological insights to your lipidomics research by adding mass spectrometry imaging to gain location data, lost when homogenizing samples for LC-MS analysis. Learn how mapping specific lipid concentrations can be used to identify tissue regions or abnormal cell types linked with disease with these application notes.

Add biological insights to your lipidomics research by adding mass spectrometry imaging to gain location data, lost when homogenizing samples for LC-MS analysis. Learn how mapping specific lipid concentrations can be used to identify tissue regions or abnormal cell types linked with disease with these application notes.

Application Notes

Application Notes

Content Feature

Discovery Lipidomics | LC & MS Solutions for Lipidomics Research

Discovery Lipidomics | LC & MS Solutions for Lipidomics Research
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Solutions

Streamline your analysis and accelerate sample throughput with system solutions tailored to the needs of lipidomics research.

Streamline your analysis and accelerate sample throughput with system solutions tailored to the needs of lipidomics research.

The next evolution in separation science is here

The next evolution in separation science is here
ACQUITY Premier System

Maximize sensitivity, repeatability, and robustness of your LC and LC-MS applications with ACQUITY Premier System. It offers improvements in separation and detection of metal-sensitive analytes, enabling you to minimize the risk of undetected analytes – for increased efficiency and confidence in your results.

Ultimate power, ultimate performance. Redefine the boundaries of science.

Ultimate power, ultimate performance. Redefine the boundaries of science.
SELECT SERIES Cyclic IMS

Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.

Designed to deliver

Designed to deliver
DESI XS

Identify the spatial localization of sample components quickly and easily with increased sensitivity using DESI XS, the high-performance sprayer that makes it possible to visualize compounds at previously unobtainable levels.

All the benefits of time-of-flight technology. Redefined performance.

All the benefits of time-of-flight technology. Redefined performance.
SELECT SERIES MRT

Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology.

Without discovery, decisions are made in the dark

Without discovery, decisions are made in the dark
SYNAPT XS High Resolution Mass Spectrometer

Obtain ultimate flexibility and freedom of analytical choice to support scientific creativity and technical success with SYNAPT XS that incorporates SONAR and HDMS to efficiently interrogate your complex mixtures.

Complete coverage for confident characterization

Complete coverage for confident characterization
Xevo G3 QTof

Maximize sample information for your analytes from detailed characterization to accurate quantitation with the Xevo G3 QTof, which enables complete confidence in your results.

Ensure your laboratory runs efficiently with Waters advanced software that provides quality and reliable results for increased productivity.

Ensure your laboratory runs efficiently with Waters advanced software that provides quality and reliable results for increased productivity.

Multimodal, intuitive, streamlined

Multimodal, intuitive, streamlined
High-Definition Imaging (HDI) Software

Simplify your mass spectral imaging workflow with High Definition Imaging (HDI) Software that organizes and processes multimodal mass spectrometry imaging data for the specificity and multiplicity that traditional techniques cannot match.

Specifically designed for your LC-MS/MS lipidomics research

Specifically designed for your LC-MS/MS lipidomics research
Lipostar2

Improve lipidomics analysis accuracy and efficiency for untargeted and semi-targeted LC-MS-based lipidomics research with Mass Analytica’s Lipostar2 Software.

Effortlessly transition from laborious manual pipetting procedures to automated processes with Lab Automation solutions from Waters.

Effortlessly transition from laborious manual pipetting procedures to automated processes with Lab Automation solutions from Waters.

Automate the tedious to focus on the critical

Automate the tedious to focus on the critical
Andrew+ Pipetting Robot

Obtain automated liquid handling with Waters Andrew+ Pipetting Robot that offers electronic pipettes and innovative labware holders. By adding connected tools for processes such as heating or labware transportation with Device+, you gain a full walk-away automation solution.

The data speaks for itself

The data speaks for itself
An example of a high-confidence identification
An example of a high-confidence identification. In this example feature, 760.5879@4.14 is identified as PC (34:1). The MS/MS spectrum is available and all the components (i.e., acyl chains) of the proposed lipid are readily identified (dark-green label).
Chromatograms representing a plasma extract
Chromatograms representing a plasma extract (ESI-) with the various lipid groups highlighted based on RT. Inset is the RT distribution gained for a number of the lipid standards measured.
Retention time reproducibility for selected injection
Retention time reproducibility for selected injection numbers 1, 50, and 100 based on LPC(16:0) m/z 496.34, PC(16:0_18:1) m/z 758.57, SM(d18:1_24:1) m/z 813.69, and TAG(52:3) m/z 874.79 with average retention time RSD value <0.19% (n=100).
Chromatographic analysis of the Avanti lipid differential ion mobility lipid mix using the RAMMP lipid methodology
Chromatographic analysis of the Avanti lipid differential ion mobility lipid mix using the RAMMP lipid methodology.

Webinars and Resources

  • Brochure

ACQUITY Premier Solution Brochure

ACQUITY Premier Solution Brochure
Download
  • Brochure

SELECT SERIES MRT - Product Solution

SELECT SERIES MRT - Product Solution
Download

Related

Targeted Omics Method Library
Enhance lab capabilities while reducing costs with the Waters Targeted Omics Method Library, designed for instant access to a diverse range of valuable targeted LC-MS/MS methods developed by experts.

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Discover the possibilities of the powerful analytical and label free detection capabilities of MS to perform molecular imaging studies able to measure the distribution of molecules in tissues for many important applications in clinical research.

Disease Focus | Cancer
Whether your research involves quantitating specific pathways or profiling the metabolome of specific cancers, Waters offers accurate, precise, and reproducible measurements of tens to hundreds of analytes from a single sample.

Learn more about Waters Discovery Lipidomics.

Learn more about Waters Discovery Lipidomics.
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Lipids are essential molecules that play many roles in living systems, from storing energy and building cell membranes to regulating communication between cells. Because lipids exist in many different forms and structures, studying them in depth can be complex. Discovery lipidomics focuses on identifying and understanding the wide range of lipids present in biological samples, helping scientists explore how they influence health, disease, and overall biological processes.

Waters discovery lipidomics solutions are designed to give researchers the most complete coverage of diverse lipidomes. With technology that minimizes sample loss and maximizes data capture, scientists can analyze lipids with greater confidence and accuracy. By combining advanced liquid chromatography with high-resolution mass spectrometry, these solutions make it possible to detect, identify, and characterize even rare or closely related lipid molecules.

Flexibility is another key advantage. Research in lipidomics can vary greatly, and Waters systems allow scientists to adapt methods to suit different types of lipids and study goals. The integration of ion mobility adds another layer of detail, helping separate and analyze lipid structures that are otherwise hard to distinguish.

Through these capabilities, discovery lipidomics solutions empower researchers to uncover new biomarkers, understand disease mechanisms, and advance both academic research and clinical applications. With Waters, scientists can achieve deeper insights into lipid biology and apply this knowledge to drive innovation in science, diagnostics, and medicine.