Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer
Quantitate with Absolute Power and eXtreme Robustness
Gain absolute confidence to make powerful decisions and reach lower limits of quantitation, maintaining optimum sensitivity for longer, with the Xevo TQ Absolute XR instrument.
Engineered for maximum productivity in a compact, sustainable design, the Waters Xevo TQ Absolute XR instrument features the new StepWave XR ion guide for enhanced resilience against contamination, even with high-throughput, complex sample matrices. That means more uptime, fewer interventions, and lab performance you can trust, all while aligning with your environmental, social, and governance (ESG) goals.
Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer
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Specifications
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API sources and ionization modes |
High performance ZSpray dual-orthogonal API sources: 1) Multi-mode source – tool free ESI/APCI/ESCi* (standard) NB – Dedicated APCI requires an additional probe (optional) 2) UniSpray ion source (optional) 3) Tool-free APCI probe (optional) 4) nanoFlow™ ESI source (optional) 5) ASAP* (optional) 6) APGC ion source (optional) 7) ionKey™ source* (optional) 8) DESI XS targeted MS imaging source* (optional) Optimized gas flow dynamics for efficient ESI desolvation Tool-free source exchange Vacuum isolation valve Tool-free access to user serviceable elements Plug-and-play probes De-clustering cone gas Software control of gas flows and heating elements |
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UniSpray ion source option |
UniSpray is an ionization technique designed to broaden the scope of compounds which can be analyzed in a single run, including those which typically optimize in ESI, APCI or APPI. Enhanced ionization efficiency and desolvation allow the potential to combine several methodologies into one, or simply enable the operator to keep the same source for multiple methods, requiring less time performing set-up and routine maintenance, and more time delivering results |
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Ion source transfer optics |
StepWave XR ion transfer optics deliver class leading UPLC-MS/MS sensitivity. The new resolving ion guide automatically removes higher mass contaminants while maintaining maximum sensitivity and speed. The unique off-axis design dramatically increases the efficiency of ion transfer from the ion source to the quadrupole MS analyzer at the same time as actively eliminating undesirable neutral contaminants. |
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Mass analyzer |
Two high-resolution, high-stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers |
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Collision cell |
T-Wave enabled for optimal MS/MS performance at high data acquisition rates; Software programmable gas control |
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Detector |
Low-noise, off-axis, long-life photomultiplier XDR Detector |
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Vacuum system |
One splitflow turbomolecular pump One vacuum backing pump |
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Regulatory approvals/marks |
CE, CB, NRTL (CAN/US), RCM |
* Not available with waters_connect.
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Software |
Systems supported on waters_connect and MassLynx version 4.2 or later |
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System setup and method development |
System parameter checks and alerts Integrated sample/calibrant delivery system + programmable divert valve Automated mass calibration Automated sample tuning Automated MRM method development UPLC-MS/MS System Check – on-column performance test |
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Automated MRM scheduling (acquisition rate assignment) |
Dwell time, inter-channel delay time and inter-scan delay time for individual channels in a Multiple MRM experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of MRM data points per chromatographic peak are acquired. The Auto-Dwell feature dynamically optimizes MRM cycle times to accommodate retention time windows that overlap. This greatly simplifies MRM method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment |
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waters_connect Software |
The waters_connect Software provides a modern user experience with a HUB design and apps that provide a consistent connected user experience across all applications. It is built for applications with convenient access to scientific apps allowing accelerated time-to-results and result quality. There are common utilities that complete the end-to-end workflow and help increase productivity and efficiency. Confidently report results with accurate, reliable, regulation-standard data from application-focused quantitative workflows with built in traceability for utmost integrity. |
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Acquisition modes |
Full scan MS Product ion scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full scan and MRM (RADAR) |
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RADAR |
An information rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components |
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Mass range |
2 to 2048 m/z |
Compare Xevo TQ Systems
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Xevo TQ-S cronosXevo TQ-S cronos
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Xevo TQ-S microXevo TQ-S micro
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Xevo TQ-XSXevo TQ-XS
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Xevo TQ Absolute XRXevo TQ Absolute XR
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Dimensions (w x h x d) |
Dimensions (w x h x d) |
Dimensions (w x h x d) |
Dimensions (w x h x d) |
Dimensions (w x h x d) |
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Dimensions (w x h x d) |
35.6 x 60 x 93 cm |
35.6 x 60 x 93 cm |
61 x 70.7 x 99.5 cm |
43 x 79 x 96 cm |
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Sensitivity key |
Sensitivity key |
Sensitivity key |
Sensitivity key |
Sensitivity key |
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Sensitivity key |
★★ |
★★★ |
★★★★ |
★★★★★ |
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Mass range |
Mass range |
Mass range |
Mass range |
Mass range |
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Mass range |
2 to 2048 m/z |
2 to 2048 m/z |
2 to 2048 m/z |
2 to 2048 m/z |
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Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
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Chromatographic configuration compatibility |
ACQUITY Arc* ACQUITY Premier ACQUITY UPC2* ACQUITY UPLC ACQUITY UPLC M-Class* |
ACQUITY Premier ACQUITY UPC2* ACQUITY UPLC ACQUITY UPLC M-Class* APGC |
ACQUITY Premier ACQUITY UPC2* ACQUITY UPLC ACQUITY UPLC M-Class* APGC |
ACQUITY Premier ACQUITY UPLC ACQUITY UPLC M-Class APGC |
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Ion sources compatibility |
Ion sources compatibility |
Ion sources compatibility |
Ion sources compatibility |
Ion sources compatibility |
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Ion sources compatibility |
APCI ASAP* ESCi* ESI |
APCI ASAP* ESCi* ESI ionKey* Nanoflow* |
APCI ASAP* ESCi* ESI ionKey* Nanoflow* |
APCI ASAP* ESCi* ESI ionKey* Nanoflow |
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Acquisition modes |
Acquisition modes |
Acquisition modes |
Acquisition modes |
Acquisition modes |
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Acquisition modes |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
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Detector ** |
Detector ** |
Detector ** |
Detector ** |
Detector ** |
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Detector ** |
Low noise, off axis, long life photomultiplier** |
Low noise, off axis, long life photomultiplier** |
Low noise, off axis, long life photomultiplier** |
Low noise, off axis, long life photomultiplier** |
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Ion source transfer optics |
Ion source transfer optics |
Ion source transfer optics |
Ion source transfer optics |
Ion source transfer optics |
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Ion source transfer optics |
StepWave XS |
StepWave XR |
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MRM speed |
MRM speed |
MRM speed |
MRM speed |
MRM speed |
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MRM speed |
555 MRM/ sec |
555 MRM/ sec |
500 MRM/ sec |
500 MRM/ sec |
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Regulatory approval *** |
Regulatory approval *** |
Regulatory approval *** |
Regulatory approval *** |
Regulatory approval *** |
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Regulatory approval *** |
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Third party software interfaces |
Third party software interfaces |
Third party software interfaces |
Third party software interfaces |
Third party software interfaces |
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Third party software interfaces |
LIMS interface MassLynx SkyLine interface |
LIMS interface MassLynx SkyLine interface |
LIMS interface MassLynx SkyLine interface |
LIMS interface MassLynx SkyLine interface |
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MassLynx security |
MassLynx security |
MassLynx security |
MassLynx security |
MassLynx security |
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MassLynx security |
Yes |
Yes |
Yes |
Yes |
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Software options |
Software options |
Software options |
Software options |
Software options |
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Software options |
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* Not available with waters_connect
** Less than 1% of Waters’ tandem quadrupole mass spectrometers require a detector replacement on an annual basis. [Source: Waters’ internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022]
*** Regulated approval marks include CE, CB, NRTL (Canada/USA), RCM
Overview
- Absolute confidence: Experience up to six times more robustness1 with the new StepWave XR ion guide, designed for superior resilience to contamination. The Xevo TQ Absolute XR Mass Spectrometer ensures consistent, reliable performance, even under the most challenging analytical conditions.
- Absolute performance: Push quantitation limits further and meet stringent regulatory requirements with up to 15x greater sensitivity2 for difficult-to-ionize negative mode compounds, setting a new benchmark in high-performance quantitation.
- Absolute efficiency: Reduce your laboratory’s environmental impact and operational costs with a mass spectrometer that consumes up to 50% less electricity and gas while generating 50% less heat than other high-performance TQ instruments.
- Absolute productivity: Streamline data analysis with waters_connect software, featuring Exception Focused Review (XFR) functionality to accelerate workflows, cutting data review time by up to 50% for more efficient, accurate results.
- Absolute versatility: Choose from our differentiated range of source options to find the technology most suited to your applications including DESI XS, APGC, and UniSpray.
1In a well-controlled experiment, performance was maintained for up to six times the duration on the Xevo TQ Absolute XR compared to the Xevo TQ Absolute; more than 12,000 samples of pesticides in fish feed matrix were analyzed
2Compared to previous generation high performance tandem mass spectrometer, the Xevo TQ-XS.
Recommended Use: Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.
Features Header
Ensure Absolute confidence with eXtreme Robustness
The Xevo TQ Absolute XR Mass Spectrometer analyzes up to six times more samples before service maintenance is required. Get the answer right first time and reduce unplanned downtime! This is one example of multiresidue pesticide analysis in a complex matrix (fish feed), for more examples please visit the brochure.
Outstanding Performance for Extended Trace Contaminant Analysis
Fish feed, an example of a complex, challenging matrix, was tested in an accelerated study using QuEChERS extraction without cleanup and without a divert-to-waste step. The Xevo TQ Absolute instrument demonstrated robust performance, operating effectively for approximately 1,500–2,000 injections (~3 months of continuous use*) before any signs of quadrupole charging appeared. The Xevo TQ Absolute XR Mass Spectrometer further extends this robustness, maintaining stable performance beyond 12,000 injections. Both instruments successfully handled over 400 MRMs in under 6 minutes, with no need for instrument venting for cleaning during the study.
* Reference: Multiresidue Pesticides Application Note 720008820
Achieve Absolute performance with improved sensitivity
To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster.
Realize Absolute efficiency and lower operational costs
Many businesses are trying to actively address environmental sustainability while also reducing operational costs – and the Xevo TQ Absolute XR instrument helps make that possible.
With lower electricity consumption, gas consumption, and BTU/hr output, it lessens the demand for air conditioning and drives down energy costs. The minimized LC-MS/MS footprint of the Xevo TQ Absolute XR Mass Spectrometer delivers more analytical power per square foot, enabling lab managers to maximize space and drive greater operational efficiency.
1 Average high-end MS/MS* refers to typical values for alternative high-end products to Xevo TQ Absolute XR instrument.
2 Highest consuming high-end MS/MS* refers to highest values for alternative high-end products to the Xevo TQ Absolute XR instrument.
Achieve Absolute productivity with flexible software options
Unlock the full potential of the instrument when paired with our next-generation solution software. From automated data processing to the time-saving Exception Focused Review (XFR) feature, you’ll streamline data review time by up to 50% and spend more time advancing your science.
Built on a secure, traceable platform, waters_connect for Quantitation is built to accelerate your LC-MS/MS workflows. giving you the absolute confidence to scale, adapt, and lead in any environment.
For labs that need proven versatility across applications, the Waters MassLynx Software continues to deliver time-tested flexibility and control.
Accelerating your success with award-winning service
Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with the Waters comprehensive analytical solutions with expert training (APS) and flexible and cost-effective solutions to advance your business with system service (FlexCHOICE), trade-ins and technological upgrades (FlexUP).
Cover more applications from our range of complementary technologies
Choose from our comprehensive range of ionization technologies providing differentiated application coverage to get the most from your analyses.
UniSpray - Absolute potential unlocked. Enable your lab to improve process efficiency through potential gains in sensitivity, precision and reduced matrix effects, relative to the equivalent electrospray ionization source option.3
APGC - The next generation of GC is already here with Atmospheric Pressure Gas Chromatography offering labs absolute power - a powerful alternative to electron ionization technology, enabling low limits of detection, confident compound identification, and confirmation.
DESI XS - With a combination of mass spectrometry imaging (MSI) and tandem quadrupole mass spectrometry, a remarkable technique emerges to perform sensitive, fast, and quantitative MSI directly on sample surfaces.
3 https://link.springer.com/article/10.1007/s00216-019-01886-z
Resources
Documents
Explore documents, videos, and other resources to support your Waters solution.
Related
Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer
The Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer is the pinnacle of sensitivity, efficiency, and sustainability, designed to overcome the most demanding analytical challenges with confidence. This state-of-the-art instrument delivers exceptional performance, enabling laboratories to quantify even the most challenging small mass and negative ionizing compounds with unmatched precision. Whether your goals are meeting stringent regulatory requirements or advancing scientific research, the Xevo TQ Absolute XR provides the tools to achieve success with ease.
Reaching lower limits of quantitation for complex compounds is no longer a challenge. The Xevo TQ Absolute XR provides up to 15 times greater sensitivity for difficult-to-analyze negative ionizing compounds compared to its predecessor, ensuring faster, more confident decision-making. Whether analyzing polar pesticides, small organic molecules, or other challenging analytes, this mass spectrometer offers the performance needed to meet regulatory requirements and exceed expectations in routine and advanced workflows.
The Xevo TQ Absolute XR helps laboratories meet their environmental, social, and governance (ESG) commitments without sacrificing performance. It consumes approximately 50% less electricity and gas, produces 50% less heat, and requires less air conditioning compared to other high-performance TQ mass spectrometers, significantly reducing operational costs. Its compact footprint optimizes laboratory space, providing more analytical capability per square foot and supporting sustainable, efficient lab management.
Designed to streamline workflows and maximize productivity, the Xevo TQ Absolute XR is supported by flexible software options, including waters_connect and MassLynx. The modern, app-based waters_connect platform offers intuitive features like Exception Focused Review (XFR), which can reduce data review time by up to 50%. Meanwhile, the trusted MassLynx software provides unparalleled versatility for diverse application areas, allowing laboratories to choose the solution that best fits their unique needs.
The Xevo TQ Absolute XR is built for consistent robustness and reproducibility, minimizing downtime and ensuring reliable operation over extended periods. Its advanced source shield and optimal probe positioning guidance reduce contamination from sample matrix or mobile phase salts, maintaining peak performance and decreasing maintenance frequency. This ensures uninterrupted workflows, maximizing uptime and efficiency in even the busiest laboratories.
Waters supports your success with award-winning service and training solutions tailored to your needs. From flexible service plans like FlexCHOICE to trade-in and upgrade programs like FlexUP, Waters offers comprehensive support to keep your laboratory running smoothly and ready for future challenges.
Compact, powerful, and environmentally conscious, the Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer sets a new standard for tandem quadrupole mass spectrometry. By combining superior sensitivity, reduced operational costs, and streamlined workflows, this instrument enables laboratories to achieve absolute confidence in their results while advancing sustainability goals.
Experience the Xevo TQ Absolute XR difference and unlock new possibilities for your most challenging analyses.
FAQs About the Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer
1. What types of compounds can the Xevo TQ Absolute XR analyze?
The Xevo TQ Absolute XR is designed to analyze a wide range of compounds, including small molecules, polar pesticides, pharmaceuticals, metabolites, and environmental contaminants. Its exceptional sensitivity for negative ionizing compounds makes it ideal for challenging analytes that are difficult to quantify with traditional mass spectrometry systems. The system's versatility allows it to handle complex sample matrices across industries, including food safety, environmental testing, clinical research, and pharmaceutical development.
2. What is the minimum limit of quantitation (LOQ) that can be achieved with this system?
The Xevo TQ Absolute XR is capable of achieving extremely low limits of quantitation (LOQs), even for challenging compounds. With sensitivity improvements of up to 15 times compared to previous models, it can reliably detect and quantify trace-level analytes in complex matrices. The exact LOQ depends on the specific application, analyte, and experimental conditions, but the system is engineered to meet stringent regulatory requirements for even the most demanding workflows.
3. How does the system minimize carryover and contamination during analysis?
The Xevo TQ Absolute XR incorporates advanced features to minimize carryover and contamination, ensuring consistent performance and reliable results. It uses programmable method settings to reduce residual analytes, while its optimized source shield protects the instrument from contamination caused by sample matrices and mobile phase salts. Additionally, precise probe positioning minimizes the risk of contamination, extending the instrument's uptime and reducing the need for frequent maintenance or cleaning.
4. How does the Xevo TQ Absolute XR reduce electricity and gas consumption?
The Xevo TQ Absolute XR is designed with sustainability in mind, consuming approximately 50% less electricity and gas than traditional high-performance triple quadrupole mass spectrometers. Its energy-efficient design also produces 50% less heat output, reducing the demand for air conditioning in the laboratory. This not only lowers operational costs but also supports environmental sustainability by reducing the lab's overall carbon footprint. These efficiency improvements make the Xevo TQ Absolute XR an environmentally conscious choice for modern analytical laboratories.
