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Analysis and Purification of Synthetic Oligonucleotides, DNA Restriction Fragments, PCR Products and...
Library Number: LITR10010599 | Format: PDF | File Size: 1816.23 kB | Year: 1991 | Content Type: Literature

Analysis and Purification of Synthetic Oligonucleotides, DNA Restriction Fragments, PCR Products and Plasmids by HPLC

Mass Confirmation and Purity Analysis of PCR Primer and Probe Reagents Using High Sensitivity Ion-pa...
Library Number: APNT135092191 | Format: Web Page | File Size: - | Year: 2022 | Content Type: Application Notes

This application note demonstrates the use of optimized IP-RPLC and a compliance-ready benchtop Tof instrument for the quality assessment of PCR test reagents used in the SARS-CoV-2 CDC assay.

BioAccord Academia Infographic
Library Number: MRKT135092125 | Format: PDF | File Size: 2770.99 kB | Year: 2022 | Content Type: Marketing/Online Tools

This infographic demonstrates that, the BioAccord system can answer your scientific questions quickly, easily, and without LC-MS experience.

The Benefits of waters_connect MRM Processing Application, MS Quan
Library Number: LITR135092021 | Format: PDF | File Size: 1692.25 kB | Year: 2021 | Content Type: Literature

The objective of this white paper is to discuss the data processing app called MS Quan that will deliver the ability to quantify and report data on the waters_connect platform for Waters tandem quadrupole mass spectrometer-based LC-MS systems.

Automated Method Development Using Analytical Quality-by-Design for Stability Indicating Methods
Library Number: APNT135091884 | Format: Web Page | File Size: - | Year: 2021 | Content Type: Application Notes

This application note demonstrates, the development of a stability indicating method used to monitor Tenofovir alafenamide fumarate drug substance after exposure to forced degradation conditions. An automated, statistical approach was employed by utilizin...

Development of a Multiproduct Method for Analysis of Cholesterol-Lowering Drugs by UltraPerformance ...
Library Number: APNT135091807 | Format: Web Page | File Size: - | Year: 2021 | Content Type: Application Notes

This application note demonstrates the steps of a method development based on design of experiments approach using the ACQUITY UltraPerformance Convergence Chromatography (UPC²) System. The studied compounds belong to statin class, used for lowering high ...

Instrument Considerations for Successful Adaptation of Amino Acid Analysis Methods which Utilize Pre...
Library Number: APNT135091809 | Format: Web Page | File Size: - | Year: 2021 | Content Type: Application Notes

This application note demonstrates the Amino acid analysis (AAA) by high-performance liquid chromatography has its own unique challenges due to the chemical and physical properties of the analytes.

Authentication of Cocoa Butter by Direct Analysis using RADIAN ASAP with LiveID
Library Number: APNT135091796 | Format: Web Page | File Size: - | Year: 2021 | Content Type: Application Notes

This application brief demonstrates the use of RADIAN ASAP with LiveID to swiftly identify adulterated cocoa butter. LiveID enabled us to transform complex raw MS data into simple-to-interpret chemometric models.

Comparable Chromatographic Performance for Amino Acid Analysis Using the AccQ•Tag Ultra VanGuard Pre...
Library Number: APNT135091783 | Format: Web Page | File Size: - | Year: 2021 | Content Type: Application Notes

This application note demonstrates the analysis of complex matrices can cause column performance issues when performed routinely.

Instrument Considerations for Successful Adaptation of Amino Acid Analysis Methods Which Utilize Pre...
Library Number: APNT135091786 | Format: Web Page | File Size: - | Year: 2021 | Content Type: Application Notes

This application note demonstrates the original ACQUITY UPLC methods developed for amino acid analysis have been successfully adapted for the ACQUITY UPLC H-Class PLUS Binary System with no loss of performance.

Analysis of Aminoglycosides in Foods Using a Zwitterionic Stationary Phase and Liquid Chromatography...
Library Number: APNT135091778 | Format: PDF | File Size: 1861.39 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates about HILIC-MS/MS method which provides a good solution for the screening and quantification of AMGs in foods.

HILIC as an Alternative Separation Mode for Intact Mass Confirmation of Oligonucleotides on the BioA...
Library Number: APNT135090878 | Format: PDF | File Size: 1029.14 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates about the BioAccord LC-MS System, which enables waters_connect users to perform rapid and accurate intact mass confirmations for small and medium size oligonucleotides (up to 50-mers).

Waters Premier Standards to Investigate the Inertness of Chromatographic Surfaces
Library Number: APNT135080186 | Format: PDF | File Size: 433.54 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the ability to assess the inertness of the recently introduced ACQUITY Premier System, which has been designed to eliminate metal-analyte secondary interaction.

Improving Recovery and Quantitation of Oligonucleotide Impurities Using MaxPeak HPS Technology
Library Number: APNT135083281 | Format: PDF | File Size: 653.81 kB | Year: 2021 | Content Type: Application Notes

ACQUITY Premier Columns and LC systems were designed with MaxPeak High Performance Surfaces Technology to address the variability in the analysis of metal-sensitive analytes such as oligonucleotides. The ACQUITY Premier Solution offers out-of-the-box perf...

LC and LC-MS Consumables for Bioseparations - Wall Chart
Library Number: MRKT134669227 | Format: PDF | File Size: 2315.83 kB | Year: 2021 | Content Type: Marketing/Online Tools

LC columns designed and QC tested for analytical separations of amino acids, glycans, oligonucleotides, peptides, and proteins.

Trace Level Analysis of Per- And Polyfluoroalkyl Substances (PFAS) In Solid Cosmetics Following A Me...
Library Number: PSTR135091692 | Format: PDF | File Size: 758.76 kB | Year: 2021 | Content Type: Posters

This poster presented at virtual PFAS conference from December 6-10 for the 2021,held at Michigan.

Targeted Analysis of Drugs for Pill Testing Applications
Library Number: APNT135091706 | Format: PDF | File Size: 1380.59 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the Drug and pill testing is a harm reduction measure that aims to reduce the adverse health consequences of drug consumption at music festivals and other settings. Pill testing has been conducted in a range of global ju...

MaxPeak Premier Columns with MaxPeak High Performance Surfaces - Ordering Information
Library Number: LITR135082367 | Format: PDF | File Size: 2225.42 kB | Year: 2021 | Content Type: Literature

Waters MaxPeak Premier Columns enable scientists to have more control over their chromatographic separations with the inclusion of MaxPeak High Performance Surfaces (HPS). MaxPeak HPS are innovative technologies designed to increase analyte recovery, sens...

Analysis of Adenoviral Vector Proteins by RPLC, Native Fluorescence, and Online MS
Library Number: APNT135091667 | Format: PDF | File Size: 657.56 kB | Year: 2021 | Content Type: Application Notes

This application brief demonstrates the use of difluoroacetic acid (DFA) ion pairing and a 2.7 µm 450 Å phenyl bonded stationary phase to quickly separate the AdV proteins while obtaining high sensitivity mass spectra.

Intelligent Data Capture (IDC) Enables Optimal Xevo G2-XS Data Acquisition and Processing for Multi-...
Library Number: APNT135091624 | Format: PDF | File Size: 52.42 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the benefits of applying an acquisition-centric data reduction algorithm, intelligent data capture (IDC), on the Xevo G2-XS System for Multi-Attribute Method (MAM) Studies.

Increasing Consistency Across Biopharmaceutical Labs with the ACQUITY Premier LC Platform
Library Number: APNT135091454 | Format: PDF | File Size: 674.11 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrate that the ACQUITY Premier LC Technology is robust and capable of delivering consistent results across LC platforms and is well suited to support the analytical needs of labs across an organization.

HRMS Quantitation of Oligonucleotides Using Xevo G2-XS QTof Mass Spectrometer
Library Number: APNT135091457 | Format: PDF | File Size: 1646.13 kB | Year: 2021 | Content Type: Application Notes

This application demonstrates the quantitative and qualitative capabilities of the Xevo G2-XS QTof and its suitability for oligonucleotide bioanalysis. We also demonstrate comparable performance with the Xevo TQ-XS Triple Quadrupole Mass Spectrometer for ...

Improved SPE for LC-MS Determination of Ractopamine in Porcine and Bovine Liver: The Oasis MCX Metho...
Library Number: APNT135091481 | Format: PDF | File Size: 826.33 kB | Year: 2021 | Content Type: Application Notes

This application brief describes a simple, rapid, and effective cleanup strategy to remove co-extractives from porcine and bovine liver extracts. This is executed via Oasis MCX 96-well SPE plate processed using Otto SPEcialist.

Application of LipidQuan to the Study of Prostate Cancer and the Response to Various Treatment Thera...
Library Number: APNT135091484 | Format: PDF | File Size: 739.85 kB | Year: 2021 | Content Type: Application Notes

This application note describes the utilization of the LipidQuan Workflow7 to develop a polarity switching method for the quantification of the key lipid species involved in the biomolecular processes associated with prostate cancer and the Response to Va...

Size and Purity Assessment of Single-Guide RNAs by Anion-Exchange Chromatography (AEX)
Library Number: APNT135091337 | Format: PDF | File Size: 446.54 kB | Year: 2021 | Content Type: Application Notes

In this application note, we show that the size of several sgRNAs could be estimated by comparison to a Low Range ssRNA Ladder (50–500 bases) using an optimized anion-exchange method developed on a Waters Protein-Pak Hi Res Q Column