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Best Practices for Oligonucleotide Analysis Using Ion-Pair Reversed-Phase (IP-RP) Liquid Chromatogra...
Library Number: APNT135071755 | Format: PDF | File Size: 1177.92 kB | Year: 2020 | Content Type: Application Notes

In this application brief, Waters provides a short list of best practices to characterize oligonucleotides by ion-pair reversed-phase (IP-RP) liquid chromatography. These best practices cover separation temperature, pH optimization, pore size selection, m...

Best Practices for Maintaining Column Performance in Size-Exclusion Chromatography during Long-Term ...
Library Number: APNT135078695 | Format: PDF | File Size: 440.75 kB | Year: 2020 | Content Type: Application Notes

This application note investigates long-term Size-Exclusion Chromatography (SEC) column storage solvents using BioResolve SEC mAb Columns and the Waters mAb Size Variant Standard.

Quantifying Primary Aromatic Amines in Polyamide Kitchenware Using the ACQUITY UPLC I-Class System a...
Library Number: APNT134909760 | Format: PDF | File Size: 556.42 kB | Year: 2020 | Content Type: Application Notes

In this application note we describe a LC-MS/MS method for the analysis of 23 common PAAs in kitchenware after migration using the ACQUITY UPLC I-Class System coupled to a Xevo TQ-S micro Mass Spectrometer.

UPLC Analysis of Benzalkonium Chloride (BAC) in Consumer Products using ACQUITY UPLC CSH C18
Library Number: APNT134730079 | Format: PDF | File Size: 3199.58 kB | Year: 2020 | Content Type: Application Notes

This application note describes the accurate determination of benzalkonium chloride (BAC) content in consumer products.

Application of a Mass Confirmation Workflow for Biotherapeutics Screening
Library Number: APNT135075434 | Format: PDF | File Size: 1124.85 kB | Year: 2020 | Content Type: Application Notes

In this study, we report the development of a high throughput intact mass confirmation workflow using the BioAccord LC-MS System operated under the control of waters_connect informatics.

Determination of Haloacetic Acids and Acrylamide in Drinking Water by Direct Injection Using Liquid ...
Library Number: APNT135078336 | Format: PDF | File Size: 1023.98 kB | Year: 2020 | Content Type: Application Notes

The purpose of this work is to demonstrate a direct injection method for the determination of acrylamide and haloacetic acids in drinking water that exceeds the requirements for the new EU Drinking Water Directive 2020.

Analytical Quality by Design Based Method Development for the Analysis of Valsartan and Nitrosamines...
Library Number: APNT135078339 | Format: PDF | File Size: 773.78 kB | Year: 2020 | Content Type: Application Notes

In this application note, a software assisted AQbD approach was implemented to develop a method for the analysis of valsartan standard and six genotoxic impurities (NDMA, NMBA, NDEA, NEIPA, NDIPA, and NDBA).

Quantification of Human Papillomavirus (HPV) Antigens in the Nonavalent Vaccine GARDASIL 9
Library Number: APNT135078342 | Format: PDF | File Size: 710.28 kB | Year: 2020 | Content Type: Application Notes

A mass spectrometry assay for the simultaneous quantification of HPV L1 protein antigens in Gardasil 9 was developed.

Seized Drug Screening using the ACQUITY RDa Detector
Library Number: APNT135078345 | Format: PDF | File Size: 1111.91 kB | Year: 2020 | Content Type: Application Notes

This application note details the use of Waters' new ACQUITY RDa Detector for seized drug screening with a ten minute analysis time utilizing a dissolve, filter, dilute, and shoot sample preparation.

Acrodisc/PALL Discontinuation Postcard
Library Number: LITR135078348 | Format: PDF | File Size: 166.57 kB | Year: 2020 | Content Type: Literature

This postcard presents two new lines of Acrodisc filters: wwPTFE and MS-Grade wwPTFE.

Increasing Chromatographic Performance of Acidic Peptides in RPLC-MS-based Assays with ACQUITY PREMI...
Library Number: APNT135075223 | Format: PDF | File Size: 928.05 kB | Year: 2020 | Content Type: Application Notes

In this study, the performance gain of ACQUITY PREMIER Columns with MaxPeak HPS Technology is demonstrated with increased recovery, reproducibility, and robustness of RPLC-MS-based peptide mapping assays using the Waters NIST mAb tryptic digest standard.

Comprehending COVID-19: Structural Characterization of the Glycan Assemblies of O-linked Glycopeptid...
Library Number: APNT135078200 | Format: PDF | File Size: 777.69 kB | Year: 2020 | Content Type: Application Notes

This application exploits Waters SELECT SERIES Cyclic IMS instrument for the characterization of the glycan structures and linkages of O-linked glycopeptides.

Repeatability of the ACQUITY UPLC H-Class PLUS Bio Binary System Under Challenging Separation Condit...
Library Number: APNT135078149 | Format: PDF | File Size: 380.33 kB | Year: 2020 | Content Type: Application Notes

This application brief evaluates peptide mapping results collected on a biocompatible binary LC system over 24 hours and compares results over three days.

Determination of Aromatic Hydrocarbon Types in Middle Distillates with the Alliance HPLC System and ...
Library Number: APNT135078152 | Format: PDF | File Size: 421.06 kB | Year: 2020 | Content Type: Application Notes

This application brief highlights the use of the Waters Alliance HPLC System coupled to the Waters 2414 Refractive Index Detector to determine mono-, di-, tri+-, and polycyclic aromatic hydrocarbon contents in diesel fuels and petroleum distillates in com...

BioAccord System Brochure
Library Number: LITR135006409 | Format: PDF | File Size: 5113.92 kB | Year: 2020 | Content Type: Literature

The Waters BioAccord System is an integrated system that simplifies high performance LC-MS biopharmaceutical analysis for every user.

Empower Cloud Brochure
Library Number: LITR134966474 | Format: PDF | File Size: 2140.58 kB | Year: 2020 | Content Type: Literature

This brochure details Empower cloud services.

Adapting to Challenging PFAS Analysis with Focused Analytical
Library Number: LITR135077726 | Format: PDF | File Size: 2664.07 kB | Year: 2020 | Content Type: Literature

In this business solution learn how Vista Analytical leads the industry in PFAS analysis using Waters PFAS specific solutions, including ultra-performance liquid chromatography coupled with tandem mass spectrometry instrumentation.

DART-QDa for the Rapid Differentiation of Curcuma longa and Curcuma xanthorrhiza in Adulterated Spic...
Library Number: APNT135077703 | Format: PDF | File Size: 672.94 kB | Year: 2020 | Content Type: Application Notes

This application note describes the use of Waters DART QDa System with Live ID to successfully differentiate between seemingly identical samples of turmeric spice based on differing levels of high value antioxidant anti-inflammatory chemoprotective active...

Comprehending COVID-19: Application of UniSpray and Electrospray Ionization for the Detection of Pro...
Library Number: APNT135077658 | Format: PDF | File Size: 344.93 kB | Year: 2020 | Content Type: Application Notes

The work presented here demonstrates the application of UniSpray and Electrospray ionization sources for the detection of selected SARS-CoV-2 tryptic peptides with a Xevo TQ-XS Tandem Quadrupole Mass Spectrometer.

Backup vs Archive whitepaper: What's the Difference? Why do you Need Both?
Library Number: LITR134872580 | Format: PDF | File Size: 401.08 kB | Year: 2020 | Content Type: Literature

WHAT’S THE DIFFERENCE AND WHY YOU NEED BOTH. Understand the key differences and learn how together they can provide an efficient, comprehensive approach to managing and protecting laboratory data.

Carryover in UPLC Methods: The Case-Study of Fumonisin B2 White Paper
Library Number: LITR135077606 | Format: PDF | File Size: 1009.69 kB | Year: 2020 | Content Type: Literature

In this white paper, the carryover of FB2 is addressed, and presented as a case study to compare various strategies to minimize the amount of analyte remaining in the flow path following the use of different injector systems.

Webinar Summary - Empower Your Lab Part 3 Disaster Recovery and Business Continuity for Durable Data
Library Number: WEBC135077649 | Format: Web Page | File Size: - | Year: 2020 | Content Type: On Demand Webinar

Part 3: Disaster Recovery and Business Continuity for Durable Data

Oasis WAX for Extraction of Per- and Polyfluorinated Alkyl Substances (PFAS) from Drinking Water in ...
Library Number: APNT135047248 | Format: PDF | File Size: 396.53 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the extraction of PFAS from drinking water samples using the Waters Oasis WAX for PFAS Analysis Cartridge as an equivalent SPE chemistry for the methodology described in EPA method 533.

Voice of Customer - BioAccord GeneDesign Inc.
Library Number: LITR135077592 | Format: PDF | File Size: 1661.45 kB | Year: 2020 | Content Type: Literature

In this voice of customer the BioAccord LC-MS System has been installed in the oligonucleotide manufacturing department of GeneDesign Inc. for intermediate monitoring of oligonucleotide synthesis

Reliable and Robust Injector Precision and Linearity with the Arc HPLC System
Library Number: APNT135077577 | Format: PDF | File Size: 629.62 kB | Year: 2020 | Content Type: Application Notes

The work presented here demonstrates that the new Arc HPLC System delivers linear and highly reproducible sample injections across the range of analytical HPLC injection volumes even when the sample diluent is 100% organic.