Literature


Description
SEC/GPC, DSC, and TGA Analysis of Low Molecular Weight Poly-L-lactic Acid
Library Number: APNT135089156 | Format: PDF | File Size: 1792.99 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the Waters ACQUITY Advanced Polymer Chromatography (APC) System, TA Instruments’ Discovery 2500 Differential Scanning Calorimeter (DSC), and Discovery 5500 Thermogravimetric Analyzer (TGA) in characterizing four samples ...

ACQUITY UPLC I-Class/Xevo TQD IVD System: Analytical Performance for Antibiotics
Library Number: APNT135088992 | Format: PDF | File Size: 603.88 kB | Year: 2021 | Content Type: Application Notes

This document describes a test of the analytical performance of the ACQUITY UPLC I-Class/Xevo TQD IVD System for the analysis of ampicillin, azithromycin, cefazolin, cefepime, cefotaxime, ceftazidime, chloramphenicol, ciprofloxacin, clindamycin, daptomyci...

Case Study: Investigating Unexpected Results of a Global Cross-Laboratory Study of a USP Organic Imp...
Library Number: APNT135088925 | Format: PDF | File Size: 1112.91 kB | Year: 2021 | Content Type: Application Notes

In this application note, a global interlaboratory method transfer of a USP organic impurities method was conducted across eight sites around the world.

Determination of Regulated and Emerging Mycotoxins in Cereals, Nuts, Figs, and Animal Feeds Using Pa...
Library Number: APNT135088825 | Format: PDF | File Size: 2807.04 kB | Year: 2021 | Content Type: Application Notes

This application note describes the performance of a simple and quick sample preparation protocol and LC-MS/MS analytical method for 31 regulated and emerging mycotoxins in three different food types (cereals, nuts, figs) and animal feeds.

Data Independent HDMSE High Throughput Drug Library Screening Using the DESI XS Source
Library Number: APNT135088784 | Format: PDF | File Size: 518.62 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the utility and speed aided by advances in DESI Technology, enabling the creation of a complete, and easy to use workflow coupled to the rapid and accurate compound identification using a UNIFI Drug Library and Processin...

Qualitative and Quantitative Performance of Cyclic IMS in Nanoscale Proteomic Experiments
Library Number: APNT135088789 | Format: PDF | File Size: 603.88 kB | Year: 2021 | Content Type: Application Notes

This Application Brief SELECT SERIES Cyclic IMS is the latest iteration of QTof Mass Spectrometers and when coupled to an ACQUITY UPLC M-Class at nanoscale flow rates, is shown to exhibit excellent performance for the proteomic analysis of medium to compl...

Analysis of Water-Soluble Vitamins and Caffeine in Beverage and Multivitamin Products by Arc HPLC Sy...
Library Number: APNT135088792 | Format: PDF | File Size: 1523.27 kB | Year: 2021 | Content Type: Application Notes

This application note outlines a robust analytical method that has been developed to detect and quantify 10 water-soluble vitamins and caffeine in multivitamin tablets and vitamin enhanced beverages.

Separation and Detection of an Azido Impurity in Sartan Drug Substances Using the XSelect CSH Phenyl...
Library Number: APNT135088337 | Format: PDF | File Size: 396 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates UHPLC method with dual UV-MS detection for the quick and accurate, 3-minute analysis of this azido impurity, 5-[4’-(azidomethyl)-[1,1’-biphenyl]-2-yl)-1H-tetrazole, and the sartan APIs irbesartan, lorsartan, and valsarta...

Illustration of the Analytical Performance of the Waters MassTrak Endocrine Steroid Calibrators and ...
Library Number: APNT135088548 | Format: PDF | File Size: 327.96 kB | Year: 2021 | Content Type: Application Notes

This application brief describes a test of the analytical performance of the MassTrak Endocrine Steroid Calibrator and QC Set (IVD) using the Waters ACQUITY I-Class/Xevo TQ-S micro IVD System.

Analysis of siRNA Duplexes at Non-Denaturing UPLC Conditions Using MaxPeak Premier Column Technology
Library Number: APNT135088510 | Format: PDF | File Size: 441.72 kB | Year: 2021 | Content Type: Application Notes

This application note describes the analysis of formulation comprising of two siRNA duplexes.

Analysis of siRNA Drugs at Denaturing UPLC Conditions Using MaxPeak Premier Column Technology
Library Number: APNT135088513 | Format: PDF | File Size: 718.91 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the utility of ACQUITY Premier Peptide BEH C18, 300 Å Column for analysis of small interfering RNA (siRNA) therapeutic candidate compound

Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier
Library Number: APNT135087944 | Format: PDF | File Size: 1266.35 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates an automated, compliance-ready LC-MS workflow for purity analysis and intact mass confirmation of extensively modified oligonucleotides and their impurities.

Comprehensive APC 2D Analysis of an Eight Component Polymer Blend
Library Number: APNT135088349 | Format: PDF | File Size: 395.15 kB | Year: 2021 | Content Type: Application Notes

Separation of a blend consisting of eight components that either have a similar or same chemistry or molecular weight might not be achievable with a single technique. Co-elution of some kind is a common cause when dealing with incomplete separation. The c...

Monitoring Nutrients and Metabolites in Spent Cell Culture Media for Bioprocess Development Using th...
Library Number: APNT135088229 | Format: PDF | File Size: 1815.91 kB | Year: 2021 | Content Type: Application Notes

This application note describes a detailed reversed phase LC-MS method and a comprehensive workflow for the monitoring of compounds in cell culture media.

Routine Accurate Mass Measurement for the Identification of Impurities in Quetiapine Fumarate API Us...
Library Number: APNT135088243 | Format: PDF | File Size: 1593.7 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates a simplified workflow for routine accurate mass measurement for the identification of Quetiapine and its related impurities with the ACQUITY RDa Detector.

Released Glycan Analysis of Erythropoietin Using the ACQUITY Premier Glycan BEH C18 AX Column and Bi...
Library Number: APNT135087950 | Format: PDF | File Size: 724.81 kB | Year: 2021 | Content Type: Application Notes

This application note evaluates a method developed using the ACQUITY Premier C18 AX Column and its ability to analyze RFMS-labeled sialylated structures.

Lipid Nanoparticle Compositional Analysis Using Charged Surface Hybrid Phenyl-Hexyl Separation With ...
Library Number: APNT135087972 | Format: PDF | File Size: 409.5 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the advantage of a lower hydrophobicity stationary phase that bears a charged surface potential, namely the CSH Phenyl-Hexyl stationary phase

Enhanced Recovery of Released Glycans Using QuanRecovery Sample Vials with MaxPeak High Performance ...
Library Number: APNT135087970 | Format: PDF | File Size: 125.68 kB | Year: 2021 | Content Type: Application Notes

This work demonstrates how QuanRecovery Sample Vials with MaxPeak High Performance Surfaces (HPS) Technology can be used to increase recovery and stability of challenging analytes in the analysis of released glycans using HILIC-FLR/MS.

The BioAccord System With ACQUITY Premier for Improved Peptide CQA Monitoring
Library Number: APNT135087979 | Format: PDF | File Size: 1033.42 kB | Year: 2021 | Content Type: Application Notes

The application note demonstrates the performance gains of the BioAccord configured with the inert ACQUITY Premier resulting in increased peptide recovery and robust MS response.

Improving Released N-glycan Analysis in Biotherapeutic Development Using the ACQUITY Premier Solutio...
Library Number: APNT135084884 | Format: PDF | File Size: 748.69 kB | Year: 2021 | Content Type: Application Notes

This study demonstrates the new ACQUITY Premier System and Column technology improves the LC-FLR-MS data quality for released N-Glycan analysis.

Comprehending COVID-19: Distinct Identification of the SARS-CoV-2 Delta Variant Using the SARS-CoV-2...
Library Number: APNT135087766 | Format: PDF | File Size: 395.06 kB | Year: 2021 | Content Type: Application Notes

This application brief demonstrates the Delta variant mutations can still be captured using SARS-CoV-2 LC-MS Kit (RUO) SISCAPA Ab and be selectively identified and differentiated from the wildtype peptide found in the other variants of concern using chrom...

Method Development of Ten Antibiotic Compounds Using a Systematic Screening Protocol on an ACQUITY A...
Library Number: APNT135087733 | Format: PDF | File Size: 967.56 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the benefits of a method development protocol based on a tiered screening approach, and its use towards developing a method to separate ten antibiotic compounds.

UPLC/MS Analysis of Mono-, Di- and Oligosaccharides Using ACQUITY UPLC BEH Amide Columns
Library Number: APNT10130636 | Format: PDF | File Size: 249.38 kB | Year: 2021 | Content Type: Application Notes

This application brief highlights the UPLC-MS analysis of mono-, di-,and oligosaccharides using ACQUITY UPLC BEH Amide Columns.

Batch-to-Batch Robustness of MaxPeak Premier Columns for the Analysis Dexamethasone Phosphate and Re...
Library Number: APNT135087660 | Format: PDF | File Size: 718.73 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the robustness of MaxPeak Premier XSelect HSS T3 and XBridge BEH C18 Columns when used for the analysis of dexamethasone phosphate and related compounds.

Rapid Automated Antibody Purification Using Protein A-Coupled Magnetic Beads With Andrew+
Library Number: APNT135087577 | Format: PDF | File Size: 1123.78 kB | Year: 2021 | Content Type: Application Notes

The application note details about the rapid antibody purification protocol, which is reproducible, robust, and can extract antibodies in a high yield from cell culture media.