Literature


Description
Systematic Toxicological Analysis (STA) Using the ACQUITY QDa Mass Detector
Library Number: APNT135042267 | Format: PDF | File Size: 711.46 kB | Year: 2020 | Content Type: Application Notes

Evaluation of a fast and simple OASIS PRiME SPE method for xenobiotics in biological samples.

Evaluating BioAccord LC-MS System Performance for Deployment of a Compact, SmartMS-Enabled Biopharma...
Library Number: APNT135042074 | Format: PDF | File Size: 591.26 kB | Year: 2020 | Content Type: Application Notes

This technology brief demonstrates the Waters BioAccord system-to-system reproducibility for intact mAb glycoprofiling.

Separation and Analysis of TCA Cycle Analytes by Mixed-Mode Chromatography Coupled with Mass Spectro...
Library Number: APNT135041807 | Format: PDF | File Size: 1355.55 kB | Year: 2019 | Content Type: Application Notes

A reproducible LC-MS method is described for the analysis of the TCA cycle analytes as well as other related compounds without the need for sample derivatization or ion-pairing reagents.

Automated Peak Tracking Using Mass Detection and Fusion QbD Software
Library Number: APNT135041715 | Format: PDF | File Size: 1358.56 kB | Year: 2019 | Content Type: Application Notes

This application note describes the benefits of using Fusion QbD® and the PeakTracker technology for method development.

Analytical Quality-by-Design Based Method Development for the Analysis of Formoterol, Budesonide, an...
Library Number: APNT135037716 | Format: PDF | File Size: 453.88 kB | Year: 2019 | Content Type: Application Notes

In this application note, a software assisted AQbD approach was implemented to develop a method for the analysis of formoterol, budesonide, and related compounds.

Streamlined Method Validation for Analysis of Formoterol Fumarate and Budesonide in Metered Dose Inh...
Library Number: APNT135041227 | Format: PDF | File Size: 858.49 kB | Year: 2019 | Content Type: Application Notes

This application note presents a validation of UPLC method for formoterol fumarate and budesonide active pharmaceutical ingredients using Empower Method Validation Manager (MVM).

Quantitative Analysis of Phosphatidylethanolamine and Phosphatidylcholine from Rice Oil Lecithin and...
Library Number: APNT135041160 | Format: PDF | File Size: 719.72 kB | Year: 2019 | Content Type: Application Notes

A method for the quantitative analysis of PE and PC on the ACQUITY UPLC H Class System with a PDA Detector is described.

A Quantitative UPLC-MS/MS Research Method for the Measurement of Acetaminophen and 5 Metabolites in ...
Library Number: APNT134942379 | Format: PDF | File Size: 296.86 kB | Year: 2017 | Content Type: Application Notes

Here we describe a methodology for the rapid quantification of acetaminophen in plasma.

Metabolic Profiling of Urine Samples with the SYNAPT XS High Definition (HDMS)
Library Number: APNT135040666 | Format: PDF | File Size: 740.72 kB | Year: 2019 | Content Type: Application Notes

The SYNAPT XS HDMS is the newest addition to Waters high resolution portfolio. The instrument benefits from improved sensitivity and resolution providing high quality quantitative data for metabolic profiling.

Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for the Quantification of Monoclonal Antibody Light...
Library Number: APNT135040631 | Format: PDF | File Size: 569.65 kB | Year: 2019 | Content Type: Application Notes

This work describes a selective and specific sample preparation workflows and superior chromatographic separation of mAb subunit light chains.

UPLC-MS/MS Analysis of Dihydrotesterone, Dehydroepiandrosterone, Testosterone, Androstenedione, 17-H...
Library Number: APNT134987532 | Format: PDF | File Size: 1064.56 kB | Year: 2018 | Content Type: Application Notes

This application note describes a clinical research method utilizing Oasis MAX μElution Plate technology for the extraction of steroid hormones in serum.

Perfluorinated Alkyl Substances (PFAS) in Drinking Water: Extraction Using the PS2 Cartridge in Acco...
Library Number: APNT135038861 | Format: PDF | File Size: 456.78 kB | Year: 2019 | Content Type: Application Notes

The extraction of PFAS from drinking water samples is demonstrated according to EPA method.

A Multi-Residue Method for the Analysis of Pesticides in Cannabis Using UPLC-MS/MS and APGC-MS/MS to...
Library Number: APNT135038801 | Format: PDF | File Size: 335.62 kB | Year: 2019 | Content Type: Application Notes

A single workflow for the multi-residue analysis of pesticides in cannabis is demonstrated.

Determination of Paralytic Shellfish Toxins and Tetrodotoxins in Shellfish by Ultra-High Performance...
Library Number: APNT135037879 | Format: PDF | File Size: 263.86 kB | Year: 2019 | Content Type: Application Notes

The detection, identification, and quantification of paralytic shellfish toxins and tetrodotoxin in shellfish tissues is determined.

Using Advanced Polymer Chromatography with Quaternary Solvent Manager and Evaporative Light Scatteri...
Library Number: APNT135037655 | Format: PDF | File Size: 666.23 kB | Year: 2019 | Content Type: Application Notes

The Waters ACQUITY Advanced Polymer Chromatography (APC) System is designed to operate consistently using harsh solvents.

Polymer Additive Analysis Study Using Tetrahydrofuran and Advanced Polymer Chromatography with Gradi...
Library Number: APNT135037586 | Format: PDF | File Size: 1083.2 kB | Year: 2019 | Content Type: Application Notes

The APC System, with a THF-compatible p-QSM, enables a gradient elution separation of polar and non-polar polymer additives in a mixture.

Investigation of the Xevo TQ-S cronos System’s Robustness for the Determination of Acrylamide in Pro...
Library Number: APNT135037534 | Format: PDF | File Size: 754.14 kB | Year: 2019 | Content Type: Application Notes

The performance method for the determination of acrylamide in processed foods is demonstrated by UPLC-MS/MS.

Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrat...
Library Number: APNT135037348 | Format: PDF | File Size: 811.03 kB | Year: 2019 | Content Type: Application Notes

A direct IEX-MS method with broad utility for the successful detection of mAb charge variants.

Performance Assessment of the ACQUITY UPLC H-Class PLUS Binary System
Library Number: APNT135032593 | Format: PDF | File Size: 811.54 kB | Year: 2019 | Content Type: Application Notes

The performance of the ACQUITY™ UPLC™ H-Class PLUS Binary System is studied in this technology brief.

Profiling of Carbohydrates in Honey by HILIC-MS
Library Number: APNT135036893 | Format: PDF | File Size: 805.06 kB | Year: 2019 | Content Type: Application Notes

The profiling and quantification of carbohydrates in honey is described.

Compliant Monitoring of Monoclonal Antibody Titer and Primary Structure Attributes Using a 2D-LC/MS ...
Library Number: APNT135036914 | Format: PDF | File Size: 804.79 kB | Year: 2019 | Content Type: Application Notes

This work demonstrates how a traditional 1D assay can be extended to incorporate 2D functionality using a common instrument platform.

Bioanalytical LC-MS Quantification of Itaconic Acid: A Potential Metabolic Biomarker of Inflammation
Library Number: APNT135036675 | Format: PDF | File Size: 337.77 kB | Year: 2019 | Content Type: Application Notes

This application highlights the successful extraction and quantification of itaconic acid from plasma.

Determination of Drugs of Abuse in Hair by UPLC-MS/MS: View from Brazil
Library Number: APNT135036463 | Format: PDF | File Size: 346.06 kB | Year: 2019 | Content Type: Application Notes

A robust and sensitive UPLC-MS/MS method developed for the determination of a panel of drugs of abuse in hair.

Analysis of Microcystins in Urine with 2D-LC-MS/MS - Part III
Library Number: APNT135036471 | Format: PDF | File Size: 1249.45 kB | Year: 2019 | Content Type: Application Notes

This application demonstrates the effectiveness of captive SPE extraction process for microcystins by 2D-LC-MS/MS from urine.

Analysis of Glyphosate, AMPA, and Glufosinate in Water Using UPLC-MS/MS
Library Number: APNT134976088 | Format: PDF | File Size: 271.54 kB | Year: 2018 | Content Type: Application Notes

Specific, targeted method for determination of glyphosate, AMPA, and glufosinate in water samples, without SPE, after derivatization with FMOC, by LC-MS/MS. Suitable for monitoring both drinking water and ground/surface waters for compliance with European...