Literature


Description
mAb Subunit Analysis Using the SYNAPT XS High Resolution Mass Spectrometer
Library Number: APNT135085063 | Format: PDF | File Size: 514.3 kB | Year: 2021 | Content Type: Application Notes

In this study, we compared the experiment results with data acquired under four different resolution modes: sensitivity, resolutio, high resolution, and enhanced resolution for analyzing the ~25 kD monoclonal antibody (mAb) IdeS digested subunits.

Utilization of the Arc Premier System and XSelect Premier Columns for Sensitive LC-MS Quantitation o...
Library Number: APNT135084971 | Format: PDF | File Size: 534.67 kB | Year: 2021 | Content Type: Application Notes

This application brief highlights the increased chromatographic performance for the metal sensitive steroid phosphate analytes, dexamethasone sodium phosphate, betamethasone sodium phosphate, and hydrocortisone phosphate triethylamine using the Arc Premie...

Analytical Quality by Design Based Method Development for the Analysis of Dexamethasone Phosphate an...
Library Number: APNT135084961 | Format: PDF | File Size: 808.17 kB | Year: 2021 | Content Type: Application Notes

In this application note, a UHPLC method for the analysis of metal-sensitive pharmaceuticals/related compounds using MaxPeak HPS systems and columns was developed.

Method Transfer of Size-Exclusion and Ion-Exchange Methods for Monoclonal Antibody Analysis from HPL...
Library Number: APNT135084969 | Format: PDF | File Size: 834.79 kB | Year: 2021 | Content Type: Application Notes

In this work, SEC and IEX methods are transferred from an Alliance HPLC System, an industry standard stainless-steel HPLC system, to an Arc Premier System, a modern UHPLC platform.

Challenge Accepted: Arc Premier System Increases Sensitivity and Reproducibility for Hard-to-See Com...
Library Number: APNT135084965 | Format: PDF | File Size: 1296.56 kB | Year: 2021 | Content Type: Application Notes

In this application note, we employ three applications to investigate the performance benefits achieved by the Waters Arc Premier System when paired with a MaxPeak Premier Column. The first application uses adenosine nucleotides as a probe to study the ef...

Seamless Method Transfer and Migration Between Instruments: Replicating an Aspirin and Related Subst...
Library Number: APNT135084891 | Format: PDF | File Size: 897.36 kB | Year: 2021 | Content Type: Application Notes

In this work, seamless migration of a related substances of aspirin active pharmaceutical ingredient (API) method to an Arc HPLC System is presented by demonstrating equivalent method performance.

Application of RADIAN ASAP-LiveID Platform in Flavor Type Discrimination of Chinese Baijiu and Authe...
Library Number: APNT135084767 | Format: PDF | File Size: 1088.26 kB | Year: 2021 | Content Type: Application Notes

In this application note, Waters RADIAN ASAP System was employed to discriminate the flavor type of different Chinese Baijiu, while the authenticity of Maotai was identified.

Rapid Identification of Adulteration in Edible Oils Using Direct Analysis Mass Detection Platform (R...
Library Number: APNT135084770 | Format: PDF | File Size: 1183.32 kB | Year: 2021 | Content Type: Application Notes

RADIAN ASAP is a compact, robust, and easy-to-use system that enables rapid screening of samples.

MaxPeak High Performance Surfaces Technology Improves HILIC Profiling of Released N-Glycans
Library Number: APNT135084776 | Format: PDF | File Size: 958.74 kB | Year: 2021 | Content Type: Application Notes

This application note illustrates improved glycan chromatographic recoveries and a new level of out-of-box performance, which is most pronounced for acidic glycans.

Screening Workflow for Extractables Testing of Medical Devices Using the UNIFI Scientific Informatio...
Library Number: APNT135084779 | Format: PDF | File Size: 1206.51 kB | Year: 2021 | Content Type: Application Notes

This application brief illustrates about the UNIFI Scientific Information System which provides analysts with a well-established workflow for extractable screening analysis of medical devices, supporting standards such as ISO 10993-18.

Enhancing the LC-MS/MS Analysis of B-group Vitamins with MaxPeak High Performance Surfaces Technolog...
Library Number: APNT135084739 | Format: PDF | File Size: 1294.78 kB | Year: 2021 | Content Type: Application Notes

This application note investigates the effects of the MaxPeak HPS on the analysis of B-group vitamins using liquid chromatography with tandem mass spectrometry (LC-MS/MS).

Lipid Analysis Using the ACQUITY RDa Detector with SmartMS Technology and UNIFI Application
Library Number: APNT135084450 | Format: PDF | File Size: 725.19 kB | Year: 2021 | Content Type: Application Notes

Demonstrating the use of the ACQUITY RDa Detector for the robust reproducible analysis of target lipids in biological fluids.

Quantitative Analysis of Polysorbate 20/80 in Protein-Based Biopharmaceuticals Using A One-Pot RPLC-...
Library Number: APNT135084454 | Format: PDF | File Size: 1115.89 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates an LC-MS-based hydrolysis method can be successfully deployed to detect polysorbate constituents at sub-ppm levels using a single quad mass spectrometer.

Improving Peak Capacity while Maintaining Selectivity using CORTECS Columns on an Agilent 1290 LC Sy...
Library Number: APNT135084109 | Format: PDF | File Size: 615.09 kB | Year: 2021 | Content Type: Application Notes

This application note investigates a separation of six sulfa drugs using a superficially porous CORTECS C18 Column.

Advancing Research with the SARS-CoV-2 LC-MS Kit (RUO)
Library Number: APNT135084111 | Format: PDF | File Size: 656.38 kB | Year: 2021 | Content Type: Application Notes

The SARS-CoV-2 LC-MS Kit (RUO) enables the direct detection and quantification of SARS-CoV-2 Nucleocapsid (NCAP) peptides.

Efficient Identification of Impurities in Nicotine API Using the SmartMS-Enabled ACQUITY RDa Detecto...
Library Number: APNT135084055 | Format: PDF | File Size: 1073.19 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates the efficient and easy to use workflow for the identification of Nicotine and its related impurities by using a novel compact benchtop SmartMS-enabled LC-MS system.

Analysis of Residual Pesticides and Mycotoxins in Cannabis Using UPLC-MS/MS and GC-MS/MS to Meet Cal...
Library Number: APNT135005299 | Format: PDF | File Size: 1727.44 kB | Year: 2021 | Content Type: Application Notes

In this application note, we present the use of sample extraction and dSPE cleanup with analysis by UPLC-MS/MS and/or GC-MS/MS for monitoring pesticides and mycotoxins in cannabis to meet California regulations.

Improved Recovery and Peak Shape of Sialylated O-glycopeptides of Erythropoietin (EPO) with ACQUITY ...
Library Number: APNT135083401 | Format: PDF | File Size: 566.04 kB | Year: 2021 | Content Type: Application Notes

This application brief demonstrates the benefits of ACQUITY Premier Column featuring MaxPeak High Performance Surfaces and its ability to improve the separation and recovery of sialylated O-glycopeptides in the characterization of biologics.

Green Tea Screening Using the ACQUITY RDa Detector
Library Number: APNT135083397 | Format: PDF | File Size: 366.25 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates a method for rapid, accurate profiling of green tea extract utilizing the Waters ACQUITY RDa Detector, a high-resolution LC-MS time-of-flight (ToF) mass analyzer.

Separation of Cannabinoids Using UltraPerformance Convergence Chromatography
Library Number: APNT135083548 | Format: PDF | File Size: 376.6 kB | Year: 2021 | Content Type: Application Notes

In this application brief, we describe the development of an analytical method using ACQUITY UPC2 and PDA for the separation of 7 cannabinoids.

Analysis of Soft Drink Additives with No Interference from Aspartame Degradants Using Arc HPLC Syste...
Library Number: APNT135083504 | Format: PDF | File Size: 811.3 kB | Year: 2021 | Content Type: Application Notes

This application note demonstrates a fast, simple, and accurate method for the analysis of soft drink additives on the Waters Arc HPLC System with PDA detection using the Waters Beverage Analysis Kit.

MaxPeak High Performance Surfaces Enable Reproducibility and Enhanced Experimental Robustness in Hig...
Library Number: APNT135083437 | Format: PDF | File Size: 792.09 kB | Year: 2021 | Content Type: Application Notes

This application brief aims to show that over the six-week duration of the study, outstanding reproducibility and robustness, both chromatographic and mass spectrometric, is observed.

Full Spectrum Molecular Imaging on the SYNAPT XS: Combined imaging techniques yield comprehensive re...
Library Number: APNT135067316 | Format: PDF | File Size: 1015.26 kB | Year: 2021 | Content Type: Application Notes

This application brief showcase the complementary nature of Full Spectrum Molecular Imaging on the SYNAPT XS, demonstrating the benefit of this updated fully integrated solution to MS imaging customers.

Increasing Recovery of Phosphorylated Peptides Using ACQUITY PREMIER Technology Featuring MaxPeak Hi...
Library Number: APNT135083353 | Format: PDF | File Size: 231.38 kB | Year: 2021 | Content Type: Application Notes

This application brief demonstrates how ACQUITY PREMIER Solution featuring MaxPeak High Performance Surfaces can improve data quality and productivity in the lab by improving recovery, peak shape, and reproducibility of metal-sensitive analytes.

ACQUITY PREMIER Solution Improves the UPLC-MS Analysis of Deferoxamine – an Iron Chelating Drug
Library Number: APNT135083341 | Format: PDF | File Size: 450.91 kB | Year: 2021 | Content Type: Application Notes

In this application note we compare UPLC separations for the iron chelating drug deferoxamine obtained using a standard UPLC system and column vs the ACQUITY PREMIER Solution.