Literature


Description
Small Molecule Ion Mobility Investigations into Cross-platform and Long-term Robustness of a CCS Met...
Library Number: APNT135047878 | Format: PDF | File Size: 781.69 kB | Year: 2020 | Content Type: Application Notes

This application note investigated and present the results of multiple CCS applications, involving three ion mobility platforms – two Q-ToF travelling wave ion mobility mass spectrometry platforms and a cyclic ion mobility (cIM) research platform.

Antibody Drug Conjugate (ADC) Load Characterization and Analysis Using the BioAccord and Nano DSC Sy...
Library Number: APNT135047770 | Format: PDF | File Size: 1115.72 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrate the added value of a multi-disciplinary approach to antibody drug conjugate (ADC) analysis by linking the biochemical and biophysical experiment results.

Biological Interpretation of Breast Cancer Using Rapid Multi-Omic Profiling Methods
Library Number: APNT135047771 | Format: PDF | File Size: 1408.37 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates the utility of a high throughput, multi-omic workflow (proteomics and lipidomics) for a plasma-based sample set, consisting of healthy controls and breast cancer individuals

Separation of Organic Acids with Mixed-Mode LC Column and Mass Detector
Library Number: APNT135042592 | Format: PDF | File Size: 231.98 kB | Year: 2020 | Content Type: Application Notes

Demonstrates Waters Atlantis PREMIER BEH C18 AX Column and ACQUITY QDa Mass Detector provides a fast analysis of organic acids.

Size-Exclusion Chromatography Analysis of Adeno-Associated Virus (AAV) Preparations Using a 450 Å Di...
Library Number: APNT135047399 | Format: PDF | File Size: 673.82 kB | Year: 2020 | Content Type: Application Notes

In this application note, we present optimized size-exclusion chromatography (SEC) methods that can separate soluble AAV self-associated forms and fragments under non-denaturing conditions.

Utilizing the Mixed-Mode Atlantis PREMIER BEH C18 AX Column for the Analysis of Cationic Surfactants...
Library Number: APNT135042700 | Format: PDF | File Size: 395.61 kB | Year: 2020 | Content Type: Application Notes

This technology brief demonstrates a simple method to provide an analytical solution for a selection of polar cationic surfactants using reversed-phase solvents and the mixed-mode Waters Atlantis PREMIER BEH C18 AX Column.

The Analysis of Tetracycline and Sulfonamide Antibiotics in Shrimp Tissue using Liquid Chromatograph...
Library Number: APNT135047367 | Format: PDF | File Size: 406.37 kB | Year: 2020 | Content Type: Application Notes

This application note describes the results of a successful validation of the analysis of shrimp tissue for tetracyclines, sulfonamides, trimethoprim, ormetoprim, and dapsone using the Waters™ ACQUITY UPLC I-Class PLUS System coupled to the Xevo TQ-S micr...

Analysis of Methylmalonic Acid in Serum Using the Xevo TQ-S micro for Clinical Research
Library Number: APNT135047220 | Format: PDF | File Size: 1282.03 kB | Year: 2020 | Content Type: Application Notes

This application note describes a clinical research method utilizing Ostro phospholipid removal plate technology for the extraction of MMA from serum.

Column Screening for the UPLC Separation of Plastic Additives as Part of Extractables and Leachables...
Library Number: APNT135047225 | Format: PDF | File Size: 487.71 kB | Year: 2020 | Content Type: Application Notes

This application note focuses on the selection of appropriate column chemistries to separate eighteen polymer additives routinely monitored in extractables and leachables(E&L) workflows.

Oasis WAX for Extraction of Per- and Polyfluorinated Alkyl Substances (PFAS) from Drinking Water in ...
Library Number: APNT135047248 | Format: PDF | File Size: 377.36 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the extraction of PFAS from drinking water samples using the Waters Oasis WAX for PFAS Analysis Cartridge as an equivalent SPE chemistry for the methodology described in EPA method 533.

Unparalleled Multi-Factor Authentication Mass Spectrometry of Complex Natural Products Utilizing UPL...
Library Number: APNT135047073 | Format: PDF | File Size: 1553.16 kB | Year: 2020 | Content Type: Application Notes

A Unique multi-factor authentication mass spectrometry is achieved through combined specificity of UPLC-IM-MS and Waters UNIFI scientific databases.

Analysis of Antiepileptic Drugs in Plasma for Clinical Research
Library Number: APNT135047075 | Format: PDF | File Size: 624.45 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates the capabilities of the sample preparation and UPLC-MS/MS system to quantify 18 antiepileptic drugs and metabolites in plasma.

Reversed-phase UPLC-MS/MS Analysis of Plasma Catecholamines and Metanephrines for Clinical Research
Library Number: APNT135047000 | Format: PDF | File Size: 390.06 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the quantitative analysis of plasma catecholamines and metanephrines using reversed-phase UPLC-MS/MS.

Separation of Mono and Disaccharides on ACQUITY Arc System with New Column Compartments
Library Number: APNT135044416 | Format: PDF | File Size: 542.86 kB | Year: 2020 | Content Type: Application Notes

The ACQUITY Arc System with the ACQUITY QDa Mass Detector provides a robust and reliable analytical system for the sugar analysis in foods.

Aiding Lithium Ion Secondary Battery Electrolyte Design via UPLC-MS and APGC-MS Analysis on a Single...
Library Number: APNT135046910 | Format: PDF | File Size: 1288.06 kB | Year: 2020 | Content Type: Application Notes

A protocol for determining the effect of lithium ion battery charge-discharge cycles on the composition of secondary battery electrolyte solutions and additives.

Large Volume Direct Injection Method for the Analysis of Perfluorinated Alkyl Substances (PFAS) in E...
Library Number: APNT134985829 | Format: PDF | File Size: 740.41 kB | Year: 2020 | Content Type: Application Notes

In this application note we describe the use of the recently developed ASTM 7979-17 method to analyze PFASs in environmental waters, including newer compounds of interest (ADONA, 9Cl-PF3ONS, and 11Cl-PF3OUdS).

Analysis of Legacy and Emerging Perfluorinated Alkyl Substances (PFAS) in Environmental Water Sample...
Library Number: APNT135005648 | Format: PDF | File Size: 438.32 kB | Year: 2020 | Content Type: Application Notes

Following the guidance of ISO 25101, achieve detection limits with this method on the Xevo TQ-S micro for both legacy and emerging PFASs.

Determination of Pesticide and Mycotoxin Residues in Dried Cannabis Flower: LC-MS/MS and GC-MS/MS Me...
Library Number: APNT135045756 | Format: PDF | File Size: 374.52 kB | Year: 2020 | Content Type: Application Notes

This application note describes the methodology to determine pesticides and mycotoxins in Dried Cannabis Flower currently regulated by any of the US states or Canada at the AOAC-recommended LOQ.

Terpenes in Hemp and Cannabis Determined Using EI GC-MS/MS
Library Number: APNT135045760 | Format: PDF | File Size: 1908.41 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates the analysis of terpenes in one cultivar of hemp and one cannabis cultivar using an electron ionization (EI) GC-MS/MS, a system also capable of analyzing for trace level pesticide residues.

LipidQuan Method Reference Guide: Analysis of Lipids in Plasma and Serum Samples by LC-MS/MS
Library Number: APNT135023462 | Format: PDF | File Size: 157 kB | Year: 2019 | Content Type: Application Notes

Details of sample preparation/extraction using IPA, mobile phase buffer preparation, and UPLC-MS/MS analysis of the samples is described.

Full Characterization of Polymers Using the ACQUITY Advanced Polymer Chromatography (APC) System wit...
Library Number: APNT135014388 | Format: PDF | File Size: 1586.54 kB | Year: 2019 | Content Type: Application Notes

The analyses of several polymers by ACQUITY APC system is presented.

A New Mixed-Mode Reversed-Phase/Anion-Exchange Stationary Phase Based on Hybrid Particles
Library Number: APNT135042697 | Format: PDF | File Size: 667.46 kB | Year: 2020 | Content Type: Application Notes

This application note highlights the characteristics of a new mixed-mode RP/AX stationary phase that offers very different selectivity compared to traditional RP stationary phases.

Analysis of Macrolide Antibiotics in Bovine Muscle Tissue Using Liquid Chromatography-Tandem Quadrup...
Library Number: APNT135045272 | Format: PDF | File Size: 829.97 kB | Year: 2020 | Content Type: Application Notes

This application note describes a sensitive and robust multiresidue method for the determination of 18 macrolide antibiotics.

Use of Ion Mobility TWCCSN2 Values in Non-targeted Food Additives Screening
Library Number: APNT135045240 | Format: PDF | File Size: 1707.51 kB | Year: 2020 | Content Type: Application Notes

In this application note we have investigated the utility of mass spectrometry libraries incorporating a TWCCSN2 (travelling wave collision cross section against nitrogen buffer gas) metric.

Targeted Quantification of Cell Culture Media Components by LC-MS
Library Number: APNT135044870 | Format: PDF | File Size: 458.34 kB | Year: 2020 | Content Type: Application Notes

A fast and universal LC-MS/MS method for media component analysis of cell culture medium and spent cell culture samples.