Literature


Description
Taking Advantage of Enhanced Sensitivity of the SYNAPT XS HDMS System for the Characterization of In...
Library Number: APNT135043377 | Format: PDF | File Size: 749.43 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the advanced sensitivity and resolution of the SYNAPT XS with a dilution series of trastuzumab in both denaturing and native states.

Utilizing an Automated Platform to Streamline Workflow Processes: Sample Preparation and Extraction ...
Library Number: APNT135073556 | Format: PDF | File Size: 1516.4 kB | Year: 2020 | Content Type: Application Notes

This work aims to provide a practical and broadly applicable, automated SPE strategy for the accurate and reproducible quantification of drugs of abuse and pain management drugs from urine samples in support of clinical research in forensic toxicology.

Determination of Trace Mono-Carbonyl Compounds in E-Cigarette Aerosols by LC-MS
Library Number: APNT135073521 | Format: PDF | File Size: 1542 kB | Year: 2020 | Content Type: Application Notes

This application note describes a simplified solution for the analysis of mono-carbonyls at low levels in complex aerosol sample matrices with good sensitivity and selectivity using a UPLC coupled to single quadrupole mass spectrometer (ACQUITY QDa Mass D...

Comprehending COVID-19: LC-MS/MS Analysis of Small Molecule Anti-Viral and Anti-Inflammatory Drugs i...
Library Number: APNT135073528 | Format: PDF | File Size: 1278.22 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates a method for the analysis of favipiravir, remdesivir (GS-5734), GS-441524, chloroquine, hydroxychloroquine, desethylchloroquine, lopinavir, ritonavir, and dexamethasone in plasma using 50 µL of sample.

Extending the Capabilities of the BioAccord LC-MS System with a streamlined workflow for compliant-r...
Library Number: APNT135073093 | Format: PDF | File Size: 694.7 kB | Year: 2020 | Content Type: Application Notes

The use of BioAccord LC-MS System combined with a novel informatics workflow for peptide MAM analysis.

Empowering You: Achieve More By Doing Less Webinar - Creating Custom Fields in Empower
Library Number: APNT135073046 | Format: PDF | File Size: 396.66 kB | Year: 2020 | Content Type: Application Notes

Empower Webinar #3 Worksheet - Creating Custom Fields in Empower

Empowering You: Achieve More By Doing Less Webinar - Empower 3 Software Automated Custom Calculation...
Library Number: APNT135073049 | Format: PDF | File Size: 2105.2 kB | Year: 2020 | Content Type: Application Notes

Empowering You: Achieve More By Doing Less - Empower 3 Software Automated Custom Calculations

Empowering You: Achieve More By Doing Less Webinar - Custom Fields For Assay Calculations In Food
Library Number: APNT135073054 | Format: PDF | File Size: 2089.97 kB | Year: 2020 | Content Type: Application Notes

Empowering You: Achieve More By Doing Less Webinar - Custom Fields For Assay Calculations In Food

LipidQuan-R for Diacyl-Phosphatidylcholines in Human Serum: A Rapid, Targeted UPLC-MS/MS Method for ...
Library Number: APNT135073069 | Format: PDF | File Size: 831.95 kB | Year: 2020 | Content Type: Application Notes

A rapid UPLC-MS/MS methodology has been developed for the specific and semi-quantitative analysis of diacyl-phosphatidylcholine species in biomedical research lipidomics studies.

Differentiation of Natural Vitamin E from Synthetic Vitamin E for Food and Dietary Supplement Nutrit...
Library Number: APNT135072984 | Format: PDF | File Size: 357.87 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the capability of Waters ACQUITY UPC2 system and Trefoil columns for the differentiation between natural and synthetic vitamin E.

BioResolve SEC mAb Guard Columns for Production Process and Formulation Development Samples
Library Number: APNT135072999 | Format: PDF | File Size: 798.68 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the utility of the BioResolve SEC mAb, 200 Å, 2.5 µm Guard Column to provide effective protection for an analytical BioResolve SEC, 2.5 µm, 7.8 x 300 mm Column, and having minimum impact on resolution.

Developing a Quantitative Surrogate Peptide Assay – Peptide mapping through MRM Optimization for Mea...
Library Number: APNT135072951 | Format: PDF | File Size: 1174.32 kB | Year: 2020 | Content Type: Application Notes

The work herein describes a complete workflow for assay development of Fc containing therapeutics. Peptide mapping experiments were used to characterize and identify appropriate peptides for quantification.

Routine Quantitation of Polychlorinated Biphenyls (PCBs) in Sediments Using Electron Ionization GC-M...
Library Number: APNT135072928 | Format: PDF | File Size: 1098.77 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates to evaluate the Xevo™ TQ-GC as a fit for purpose electron ionization (EI) GC-MS/MS for the routine analysis of polychlorinated biphenyls (PCBs) extracted from sediment samples.

Multiresidue Method for the Quantification of Pesticides in Fruits, Vegetables, Cereals and Black Te...
Library Number: APNT135072936 | Format: PDF | File Size: 903.31 kB | Year: 2020 | Content Type: Application Notes

In this application note we demonstrate a multi-residue UPLC-MS/MS method developed for the determination of 552 pesticides and relevant metabolites for pesticide residue analysis.

GlycoWorks RapiFluor-MS Automation Using the Andrew+ Pipetting Robot
Library Number: APNT135072949 | Format: PDF | File Size: 864.45 kB | Year: 2020 | Content Type: Application Notes

In this application brief, the process of optimization for the 8-sample GlycoWorks RapiFluor-MS released N-glycan protocol is detailed.

Determination of Aromatic Hydrocarbon Types in Aviation Fuels and Petroleum Distillates with the All...
Library Number: APNT135072810 | Format: PDF | File Size: 519.37 kB | Year: 2020 | Content Type: Application Notes

This application brief highlights the use of the Waters Alliance HPLC System coupled to the Waters 2414 Refractive Index Detector to determine mono- and di-aromatic hydrocarbon contents in petroleum distillates and aviation fuels in compliance with the AS...

How-to-Series Video 4: Application Note
Library Number: APNT135072819 | Format: Web Page | File Size: - | Year: 2020 | Content Type: Application Notes

How To Video Episode #4 – Improve LC-MSMS performance

Determination of Chlorate and Perchlorate in Infant Milk Using Waters Anionic Polar Pesticide Column...
Library Number: APNT135035297 | Format: PDF | File Size: 259.39 kB | Year: 2020 | Content Type: Application Notes

This application note evaluates the performance of the ACQUITY UPLC I-Class System, coupled with the Xevo TQ-XS Mass Spectrometer, for the determination of chlorate and perchlorate in dairy products.

Lessons from COVID-19: Verifying Performance of an HPLC-UV Method with MS-Compatible Conditions for ...
Library Number: APNT135072742 | Format: PDF | File Size: 773.19 kB | Year: 2020 | Content Type: Application Notes

In this application brief we present a fast and reliable HPLC-UV method for chloroquine phosphate analysis with use of MS-compatible buffer, while meeting the USP system suitability requirements.

High Resolution Size-Exclusion Chromatography Separations of mAb Aggregates, Monomers, and Fragments...
Library Number: APNT135072714 | Format: PDF | File Size: 1299.15 kB | Year: 2020 | Content Type: Application Notes

The objective of this application note is to show how LC system dispersion volume affects mAb separations based on the selected SEC column I.D. and length.

Development of a Sensitive High Resolution Mass Spectrometry Method for Quantitation of N-Nitrosamin...
Library Number: APNT135072630 | Format: PDF | File Size: 1064.42 kB | Year: 2020 | Content Type: Application Notes

In this application note we demonstrate the ability to attain both sensitive and selective detection of six N-nitrosamines (NDMA, NDEA, NDIPA, NEIPA, NMBA, and NDBA) using Tof-MRM acquisition on the Xevo G2-XS QTof.

Separation and Analysis of TCA Cycle Analytes by Mixed-Mode Chromatography Coupled with Mass Spectro...
Library Number: APNT135041807 | Format: PDF | File Size: 1355.55 kB | Year: 2020 | Content Type: Application Notes

A reproducible LC-MS method is described for the analysis of the TCA cycle analytes as well as other related compounds without the need for sample derivatization or ion-pairing reagents.

Method Transfer of a Fast Gradient from a Binary HPLC to an Arc HPLC System
Library Number: APNT135071981 | Format: PDF | File Size: 641.05 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the method transfer for a fast gradient method from an HPLC legacy system to the Arc HPLC System.

Development of a Sensitive High Resolution Mass Spectrometry Method for Quantitation of N Nitrosamin...
Library Number: APNT135071818 | Format: PDF | File Size: 1068.72 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates the ability to attain both sensitive and selective detection of six N-nitrosamines using Tof-MRM acquisition on the Xevo G2-XS QTof.

Comprehending COVID-19: Fast Analysis of Ribavirin and Related Compounds Using Hydrophilic Interacti...
Library Number: APNT135071822 | Format: PDF | File Size: 521.06 kB | Year: 2020 | Content Type: Application Notes

This application note reports a method for the separation of ribavirin and related compounds using HILIC.