Literature


Description
How-to-Series Video 2: Application Notes
Library Number: APNT135069380 | Format: Web Page | File Size: - | Year: 2020 | Content Type: Application Notes

How-to-Series Video 2 - Getting sample preparation right is probably the most important step in any analysis

High Sensitivity Quantitation of Nitrosamine Genotoxic Impurities: LC-MS Analysis of Ranitidine Drug...
Library Number: APNT135068607 | Format: PDF | File Size: 1213.39 kB | Year: 2020 | Content Type: Application Notes

This application note presented herein, provides practical considerations for optimization of LC-MS conditions to achieve sensitive and robust simultaneous quantification of several nitrosamine GTIs (NDMA, NDEA, NEIPA, NDIPA, NDBA, and NMBA).

Size-Exclusion Chromatography (SEC) of Proteins and Peptides Application Notebook
Library Number: APNT135068236 | Format: PDF | File Size: 34443.85 kB | Year: 2020 | Content Type: Application Notes

In this application notebook, Waters has compiled the following references to help guide through some common challenges and applications associated with SEC of peptides and proteins. The topics covered range from fundamentals of SEC to suggested best prac...

Quality Control and Automation Friendly GlycoWorks RapiFluor-MS N-Glycan Sample Preparation
Library Number: APNT134865160 | Format: PDF | File Size: 779.27 kB | Year: 2015 | Content Type: Application Notes

This application note demonstrates RapiFluor-MS glycan labeling procedure with larger volume, simplified liquid transfer to improve ease of use and automatability.

Waters Food Testing Application Notes Booklet
Library Number: APNT134800757 | Format: PDF | File Size: 11822.48 kB | Year: 2020 | Content Type: Application Notes

Read our in-depth application notes to learn about the latest analytical methods for pesticides, food allergens, veterinary drugs, food contact materials, natural toxins, food authenticity, and food ingredients testing.

Application of Intentionally Attenuated MRM Transitions for the Analysis of Natural Products
Library Number: APNT135067849 | Format: PDF | File Size: 820.91 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates to develop intentionally attenuated MRM transitions in order to allow the quantitative analysis of natural product constituents of disparate abundance within a single acquisition.

Routine Quantitation of PAHs in Sediments Using Electron Ionization GC-MS/MS
Library Number: APNT135067862 | Format: PDF | File Size: 826.88 kB | Year: 2020 | Content Type: Application Notes

Xevo TQ-GC is a fit for purpose GC-MS/MS solution for routine analysis of PAHs in sediment samples.

Quick Analysis of N-nitrosodimethylamine (NDMA) in Ranitidine Drug Substance and Drug Product by HPL...
Library Number: APNT135067870 | Format: PDF | File Size: 395.41 kB | Year: 2020 | Content Type: Application Notes

The ACQUITY Arc System with PDA Detector, integrated with an ACQUITY QDa Mass Detector, enables accurate analysis of NDMA in ranitidine drug substance and drug product.

Analysis of Methylmalonic Acid in Serum Using the Xevo TQ-S micro for Clinical Research
Library Number: APNT135047220 | Format: PDF | File Size: 1282.03 kB | Year: 2020 | Content Type: Application Notes

This application note describes a clinical research method utilizing Ostro phospholipid removal plate technology for the extraction of MMA from serum.

Ion Mobility-Enabled Metabolite Identification of Tienilic Acid and Tienilic Acid Isomer Using Mass-...
Library Number: APNT135067300 | Format: PDF | File Size: 810.14 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates the use of HDMSE and Mass-MetaSite/WebMetabase processing for rapid identification of TA and TAI, and related metabolites, in rat urine samples collected at three time points post-administration of these drugs.

Full Spectrum Molecular Imaging on the SYNAPT XS: Combined imaging techniques yield comprehensive re...
Library Number: APNT135067316 | Format: PDF | File Size: 1009.33 kB | Year: 2020 | Content Type: Application Notes

This application brief showcase the complementary nature of Full Spectrum Molecular Imaging on the SYNAPT XS, demonstrating the benefit of this updated fully integrated solution to MS imaging customers.

DESI XS – Technology Brief
Library Number: APNT135066555 | Format: PDF | File Size: 1452.5 kB | Year: 2020 | Content Type: Application Notes

DESI XS – a new fully integrated source delivering improved build quality, reliability and simplicity for MS imaging.

Enhanced Performance of the SYNAPT XS and Its Impact on Hydrogen Deuterium Exchange Mass Spectrometr...
Library Number: APNT135066562 | Format: PDF | File Size: 512.2 kB | Year: 2020 | Content Type: Application Notes

The SYNAPT XS provides enhanced sensitivity and improved data quality for HDX MS experiments.

A Single System for the Characterization of Molecular Weight Distribution and Additives in Polymers
Library Number: APNT135057775 | Format: PDF | File Size: 1106.28 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates how an ACQUITY Advanced Polymer Chromatography (APC) System combined with the Waters 2414 Refractive Index (RI) Detector and the Waters ACQUITY QDa Mass Detector can accelerate polymer analysis accurately measuring poly...

Utilizing UPLC Separation to Enable the Analysis of 19 Steroid Hormones in Serum for Clinical Resear...
Library Number: APNT135065674 | Format: PDF | File Size: 659.22 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates to successfully develop a UPLC™- MS/MS method for the low-level quantification of 19 steroid hormones using the Xevo™ TQ-XS Tandem Mass Spectrometer, while separating isobaric steroid hormones to minimize mass detection...

Cross Validation of an Automated LipidQuan Sample Preparation Procedure
Library Number: APNT135064362 | Format: PDF | File Size: 948.6 kB | Year: 2020 | Content Type: Application Notes

This application brief evaluates and cross-validates an automated, high throughput sample preparation procedure that could be utilized as a part of the LipidQuan workflow.

Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS
Library Number: APNT135064334 | Format: PDF | File Size: 473.03 kB | Year: 2020 | Content Type: Application Notes

The performance of the BioAccord System by developing LC-optical and LC-MS methods for the analysis of intact AAV capsid proteins and to apply these methods to the AAV8 serotype as a case study for the improved characterization of capsid proteins, includi...

Enhanced Glycopeptide Identification Using the SYNAPT XS Q-ToF with Ion Mobility Enabled Wideband En...
Library Number: APNT135062648 | Format: PDF | File Size: 1536.03 kB | Year: 2020 | Content Type: Application Notes

This application brief examines the utility of ion mobility enabled Wideband Enhancement to boost signal, increase coverage, and improve the identification confidence of glycopeptides.

Rapid Proteomic Analysis Using 1 mm Scale Chromatography, Providing the Required Throughput for Larg...
Library Number: APNT135061136 | Format: PDF | File Size: 1166.2 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the applicability of 1 mm scale chromatography for proteomic analyses, exhibiting a six-fold increase in throughput while maintaining similar identification results of that achieved with nanoscale chromatography.

Enabling Routine and Reproducible Intact Mass Analysis When Data Integrity Matters
Library Number: APNT135007110 | Format: PDF | File Size: 1605.42 kB | Year: 2019 | Content Type: Application Notes

This study describes how the BioAccord™ System, a compact high-performance LC-MS platform, streamlines data acquisition, processing, and reporting for intact mass analysis.

Metabolite Identification of Complex Cyclic Peptides Using WebMetabase, Ion Mobility-Enabled DIA, an...
Library Number: APNT135060106 | Format: PDF | File Size: 1153.8 kB | Year: 2020 | Content Type: Application Notes

The primary goal of this study was to verify that data for complex peptide structures could be rapidly acquired using HDMSE acquisition on a Vion IMS QTof MS and subsequently processed for catabolism identification using Mass MetaSite and WebMetabase dire...

Difluoroacetic Acid as a Mobile Phase Modifier for LC-MS Analysis of Small Molecules
Library Number: APNT135058288 | Format: PDF | File Size: 546.79 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the use of IonHance Difluoroacetic Acid (DFA) as a mobile phase modifier for LC MS analysis of small molecules and compare it to formic acid and trifluoroacetic acid (TFA) modifiers.

An Automated Compliance-Ready LC-MS Workflow for Intact Mass Confirmation and Purity Analysis of Oli...
Library Number: APNT135057716 | Format: PDF | File Size: 4555.92 kB | Year: 2020 | Content Type: Application Notes

This application note describes a streamlined, compliance-ready workflow for oligonucleotide analysis employing the BioAccord System operating under waters_connect HUB data acquisition and processing software.

Method Development Tools for More Efficient Screening of Biopharmaceutical Method Conditions Using t...
Library Number: APNT135057723 | Format: PDF | File Size: 469.14 kB | Year: 2020 | Content Type: Application Notes

This two-part application note series demonstrates how features of the ACQUITY Arc Bio System, such as column-switching capabilities and buffer preparation technology, can help streamline method development. In this part, a common buffer system is used to...

Simple Approach for the Removal of Phospholipids in Small Molecule Quantitative Bioanalysis Using Os...
Library Number: APNT135054874 | Format: PDF | File Size: 403.52 kB | Year: 2020 | Content Type: Application Notes

In this application note, we demonstrate the application of the Ostro Pass-through Sample Preparation Plate for plasma phospholipid removal prior to the LC-MS analysis of genfitinib.