Literature


Description
Increasing Chromatographic Performance of Acidic Peptides in RPLC-MS-based Assays with ACQUITY PREMI...
Library Number: APNT135075223 | Format: PDF | File Size: 928.05 kB | Year: 2020 | Content Type: Application Notes

In this study, the performance gain of ACQUITY PREMIER Columns with MaxPeak HPS Technology is demonstrated with increased recovery, reproducibility, and robustness of RPLC-MS-based peptide mapping assays using the Waters NIST mAb tryptic digest standard.

Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology
Library Number: APNT135075015 | Format: PDF | File Size: 1270.94 kB | Year: 2020 | Content Type: Application Notes

This application note describes a single, analytical method for the extraction and quantification of various oligonucleotides (15-35T). Using reversed-phase (RP) and mixed-mode ion exchange µElution solid phase extraction (SPE) sample preparation provided...

Comprehending COVID-19: Using the Atlantis PREMIER BEH C18 AX Mixed-Mode Column for the Analysis of ...
Library Number: APNT135075018 | Format: PDF | File Size: 337.24 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates that sharper peaks can be achieved for umifenovir through the use of a mixed-mode stationary phase versus a more conventional reversed-phase material.

Comprehending COVID-19: Maximizing LC-MS Detection Dynamic Range for Multiple Reaction Monitoring Ba...
Library Number: APNT135075039 | Format: PDF | File Size: 428.65 kB | Year: 2020 | Content Type: Application Notes

In this application brief, the combination of selected chemistries and consumables, using the ACQUITY UPLC I-Class PLUS System and Xevo TQ-XS Tandem Quadrupole Mass Spectrometer, are demonstrated for the detection and quantification of SARS-CoV-2 proteins...

Comprehending COVID-19: Multiple Reaction Monitoring Transition Selection and Optimization Strategie...
Library Number: APNT135074918 | Format: PDF | File Size: 698.31 kB | Year: 2020 | Content Type: Application Notes

The work presented here demonstrates application of the MassLynx Skyline Interface for automated peptide Multiple Reaction Monitoring selection and optimization with a Xevo TQ-XS Tandem Quadrupole Mass Spectrometer.

A Complete Workflow for the Determination of Drugs that Conforms to the Society of Hair Testing (SoH...
Library Number: APNT135074842 | Format: PDF | File Size: 538.85 kB | Year: 2020 | Content Type: Application Notes

This application brief details a workflow that can be used to quantify a panel of drugs at cut-off concentrations recommended by both the SoHT and EWDTS from a single hair specimen using a commercially available extraction buffer and OASIS PRiME MCX 96-We...

Utilization of MaxPeak High Performance Surfaces for Improved Separation and Recovery of Analytes As...
Library Number: APNT135041807 | Format: PDF | File Size: 1355.55 kB | Year: 2020 | Content Type: Application Notes

A reproducible LC-MS method is described for the analysis of the TCA cycle analytes as well as other related compounds without the need for sample derivatization or ion-pairing reagents.

Determination of Anionic Polar Pesticides in Grapes using UPLC-MS with Anionic Polar Pesticide Colum...
Library Number: APNT135074795 | Format: PDF | File Size: 545.25 kB | Year: 2020 | Content Type: Application Notes

The analysis of highly polar anionic pesticides at levels 50-fold lower than the regulatory limits on ACQUITY I-Class PLUS UPLC and Xevo TQ-XS has been described in this application brief.

Analysis of Organic Acids using a Mixed-Mode LC Column and an ACQUITY QDa Mass Detector
Library Number: APNT135074490 | Format: PDF | File Size: 967 kB | Year: 2020 | Content Type: Application Notes

In this application note we describe the development of an analytical solution based on Waters Atlantis PREMIER C18 AX column and Waters ACQUITY QDa detector to address the major issues in OA analysis.

Determination of Acrylamide: Are You Avoiding Isobaric Interferences?
Library Number: APNT135074755 | Format: PDF | File Size: 377.39 kB | Year: 2020 | Content Type: Application Notes

This application brief quantifies acrylamide in processed food matrices.

Improved Peak Shape and Wide Selectivity Range with ACQUITY PREMIER Columns
Library Number: APNT135074676 | Format: PDF | File Size: 425.44 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrate the improved peak shapes obtained for metal-sensitive analytes that were enabled using ACQUITY PREMIER Columns.

Improved Chromatographic Analysis of Oligonucleotides with ACQUITY PREMIER Oligonucleotide BEH C18 C...
Library Number: APNT135074577 | Format: PDF | File Size: 516.09 kB | Year: 2020 | Content Type: Application Notes

This application note illustrates sources of oligonucleotide loss due to adsorption on metallic column hardware (frits). Solutions, columns, and best practices for improved oligonucleotide analysis are provided.

Comparison of Sub-3-µm HP-SEC Columns for the Analysis of IgG Antibody Aggregates (HMWS) and Fragmen...
Library Number: APNT135074507 | Format: PDF | File Size: 523.09 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the performance of the BioResolve SEC mAb, 7.8 x 300 mm Column in comparison to three commercial SEC, sub-3-µm, 7.8 x 300 mm columns.

Stereochemical Analysis of PLA Using the ACQUITY APC System with p-QSM and ELS Detection through the...
Library Number: APNT135074512 | Format: PDF | File Size: 924.67 kB | Year: 2020 | Content Type: Application Notes

In this application brief, we demonstrate how the highly solvent compatible capabilities of the ACQUITY APC with p-QSM and ELSD enables researchers with a quick and robust solution for applying the GPEC technique to differentiate PLA stereochemistry.

Automated Medium and High-Throughput GlycoWorks RapiFluor-MS Preparations on the Andrew+ Pipetting R...
Library Number: APNT135074361 | Format: PDF | File Size: 550.33 kB | Year: 2020 | Content Type: Application Notes

In this application brief data supporting the applicability of this automation platform for medium (24-sample) and high-throughput (48-sample) GlycoWorks RapiFluor-MS released N-glycan analysis is presented.

Targeted MRM Screening for Forensic Toxicology in Negative Electrospray Ionization Mode Using the Xe...
Library Number: APNT135012609 | Format: PDF | File Size: 342 kB | Year: 2019 | Content Type: Application Notes

A simple and sensitive UPLC-MS/MS method for the targeted MRM screening of negatively ionizing compounds in biological matrices for use in forensic toxicology laboratories.

Taking Advantage of Enhanced Sensitivity of the SYNAPT XS HDMS System for the Characterization of In...
Library Number: APNT135043377 | Format: PDF | File Size: 749.43 kB | Year: 2020 | Content Type: Application Notes

This application brief demonstrates the advanced sensitivity and resolution of the SYNAPT XS with a dilution series of trastuzumab in both denaturing and native states.

Utilizing an Automated Platform to Streamline Workflow Processes: Sample Preparation and Extraction ...
Library Number: APNT135073556 | Format: PDF | File Size: 1516.4 kB | Year: 2020 | Content Type: Application Notes

This work aims to provide a practical and broadly applicable, automated SPE strategy for the accurate and reproducible quantification of drugs of abuse and pain management drugs from urine samples in support of clinical research in forensic toxicology.

Determination of Trace Mono-Carbonyl Compounds in E-Cigarette Aerosols by LC-MS
Library Number: APNT135073521 | Format: PDF | File Size: 1542 kB | Year: 2020 | Content Type: Application Notes

This application note describes a simplified solution for the analysis of mono-carbonyls at low levels in complex aerosol sample matrices with good sensitivity and selectivity using a UPLC coupled to single quadrupole mass spectrometer (ACQUITY QDa Mass D...

Comprehending COVID-19: LC-MS/MS Analysis of Small Molecule Anti-Viral and Anti-Inflammatory Drugs i...
Library Number: APNT135073528 | Format: PDF | File Size: 1278.22 kB | Year: 2020 | Content Type: Application Notes

This application note demonstrates a method for the analysis of favipiravir, remdesivir (GS-5734), GS-441524, chloroquine, hydroxychloroquine, desethylchloroquine, lopinavir, ritonavir, and dexamethasone in plasma using 50 µL of sample.

Extending the Capabilities of the BioAccord LC-MS System with a streamlined workflow for compliant-r...
Library Number: APNT135073093 | Format: PDF | File Size: 694.7 kB | Year: 2020 | Content Type: Application Notes

The use of BioAccord LC-MS System combined with a novel informatics workflow for peptide MAM analysis.

Empowering You: Achieve More By Doing Less Webinar - Creating Custom Fields in Empower
Library Number: APNT135073046 | Format: PDF | File Size: 396.66 kB | Year: 2020 | Content Type: Application Notes

Empower Webinar #3 Worksheet - Creating Custom Fields in Empower

Empowering You: Achieve More By Doing Less Webinar - Empower 3 Software Automated Custom Calculation...
Library Number: APNT135073049 | Format: PDF | File Size: 2105.2 kB | Year: 2020 | Content Type: Application Notes

Empowering You: Achieve More By Doing Less - Empower 3 Software Automated Custom Calculations

Empowering You: Achieve More By Doing Less Webinar - Custom Fields For Assay Calculations In Food
Library Number: APNT135073054 | Format: PDF | File Size: 2089.97 kB | Year: 2020 | Content Type: Application Notes

Empowering You: Achieve More By Doing Less Webinar - Custom Fields For Assay Calculations In Food

LipidQuan-R for Diacyl-Phosphatidylcholines in Human Serum: A Rapid, Targeted UPLC-MS/MS Method for ...
Library Number: APNT135073069 | Format: PDF | File Size: 831.95 kB | Year: 2020 | Content Type: Application Notes

A rapid UPLC-MS/MS methodology has been developed for the specific and semi-quantitative analysis of diacyl-phosphatidylcholine species in biomedical research lipidomics studies.