Discovery And Identification Of Precursor Ions To Pre-Defined Product And Neutral Loss Exact Masses By HPLC-CID-MS For Metabolism Studies (ASMS 2001)

Library Number:
Castro, Perez, J;Major, H;Hoyes, J;Preece, S.
ASMS; Chicago; 27th-31st May; 2001
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Content Subtype:
Precursor ion and neutral loss acquistions are commonnly used in drug metabolism studies for the selective detection of drug related compounds. For example, neutral loss acquistions may be used to search for commong losses produced from metabolites formed by sulfate or glucuronide conjugation. These modes of acquisition have previously only been possible, within a chromatographic time frame, using tandem quadrupole mass spectrometers. This paper presents data from the in vivo metabolism ofidclofenac (o-(2,6-dichlorophenyl)aminophenylacetic acid), a commonly prescribed non-steroidal anti-inflammatory drug (NSAID), acquired using a novel acquisition mode on a quadrupole-time of flight hybrid mass spectrometere (Q-TOF). This mode allows the discovery and identification of precursor ions based upon the detection of pre-defined product ion and neutral loss exact masses.

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