Automated On-Line Solid Phase Extraction Chromatography Technique for the Direct Analysis of Tricyclic Antidepressants in Biological Matrices

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Lisa J. Southern, Tabisam Khan, Steve Preece, Hilary Major
Waters, Montreux
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NCE’s (new chemical entities) are becoming more potent, in turn the administered dosages are decreasing, which leads to lower limits of detection required (sub ng/mL). Biological samples from in vivo studies need to be analysed rapidly throughout a NCE lifecycle. The aim of this study was to evaluate an on-line sample extraction system for the direct analysis of tricyclic antidepressants (TCAs) in biological matrices. Selectivity, linearity, precision, recovery and limit of quantification were studied. This poster was presented at: Montreux LC/MS Symposium on LC/MS, SFC/MS, CE/MS and MS/MS, Montreux, Switzerland, November 10-12, 2004.

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